HLA antigens in Arab children with steroid-responsive nephrotic syndrome

Zaki, Moh'd; Daoud, Azhar S.; Saleh, Qusay A. Al; Najedi, A. Khuder Al; White, Arthur G.

doi:10.1007/bf00868269

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…In Caucasians, Egyptian and Kuwaiti children the HLA DR 07 was significantly more common in children with NS as compared to controls. However this was not observed in our study population as well as in Japanese and Chinese patients [2,9,11,13]. In Japanese children the allele HLA-DR8 was significantly more common [7].…”

Section: Discussioncontrasting

confidence: 79%

“…The etiological fraction of DQβ1*020X for patients with nephrotic syndrome in our study was moderate (0.381). The association with HLA-DQβ1*020X has been demonstrated in most previous studies in children from different ethnic populations except in Japanese children, indicating a strong association with nephrotic syndrome [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. In Caucasians, Egyptian and Kuwaiti children the HLA DR 07 was significantly more common in children with NS as compared to controls.…”

Section: Discussionmentioning

confidence: 85%

“…There have been studies from different parts of the world regarding the HLA class II DR and DQ associations with steroid sensitive nephrotic syndrome in children [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Most of these studies are small and have tested only limited alleles and yielded different associations.…”

Section: Introductionmentioning

confidence: 99%

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Is typing for HLA class II alleles beneficial in Indian children with idiopathic nephrotic syndrome?

et al. 2007

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This study was conducted to test the hypothesis that analysis of HLA class II type alleles will give important information on the prognosis of NS in children. We prospectively studied 100 consecutive children with idiopathic nephrotic syndrome and 202 controls belonging to the same geoethnic background. Typing for HLA Class II alleles at DR and DQ locus was carried out by using SSP (sequence specific oligonucleotides based method). In our study children were more likely to have nephrotic syndrome if the allele DQ-beta1*020X was present as compared to controls. On the other hand, DR-beta1*1001, DR-beta1*130X and DQ-beta1*030X were significantly lower among patients and likely to be protective. On analysing the different steroid response categories, we observed that the allele DQ-beta1*020X was significantly higher in infrequent relapsers (IFR) with a high etiological fraction of 0.714. Children were more likely to be steroid resistant if the allele DR-beta1*150X was present and the etiological fraction was high (0.754). The allele DQ-beta1*030X was significantly lower in steroid resistant patients (p=0.019, RR=0.1819, 95% CI=0.04430-0.7471) and likely to be protective. On analysing the haplotype distribution, we observed that occurrence of DR-beta1*070X-DQ-beta1*020X haplotype was significantly more common among patients with steroid sensitive nephrotic syndrome (23.94%) as compared to controls (12.5%) (p=0.01). In the steroid resistant group we observed that the haplotype DR-beta1*150X-DQ-beta1*060X was significantly more frequent as compared to steroid sensitive patients as well as controls p=0.01. We conclude that HLA typing in Indian children with NS helps to predict relapse frequency and steroid resistance.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 85%

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Is typing for HLA class II alleles beneficial in Indian children with idiopathic nephrotic syndrome?

et al. 2007

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“…There is a controversy regarding the association of HLA class II antigens and childhood SR-MCNS. Many investigators [3,16,22,26] state that children with SR-MCNS do not exhibit any significant association with class II antigens. Meanwhile, Ruder et al [21] and Bouissou et al [2] reported that in children with SR-MCNS the only association is with the combined occurrence of HLA-DR3/DR7.…”

Section: Discussionmentioning

confidence: 98%

“…Again, there is no universal negative association between childhood PNS and HLA alleles. HLA-DQW1 antigen is reduced in Kuwaiti children with PNS [26]. Abe et al [27] reported a low frequency of DQA1*0103 in Japanese children with PNS.…”

Section: Discussionmentioning

confidence: 99%

HLA alleles in frequently relapsing steroid-dependent and -resistant nephrotic syndrome in Egyptian children

2004

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The association between HLA class II antigens and childhood primary nephrotic syndrome has been reported in different populations. To investigate this association in Egyptian children, DRB1 alleles were typed by DNA polymerase chain reverse hybridization in 20 frequent relapsers/steroid-dependent and 14 steroid-resistant children with minimal change nephrotic syndrome (MCNS) and 121 unrelated healthy controls from the northern part of Egypt. The strength of the association was expressed as the relative risk (RR) estimated by the odds ratio. The DRBI*07011 allele frequency was significantly higher among patients than controls (78.9% vs. 16%, Pc <0.001). The etiological fraction (EF) was high at 0.75 [RR=20.1, confidence interval (CI)=6.0-66.7]. Similarly, patients with steroid-resistant MCNS had a higher frequency of the DRBI*07011 allele than controls (64.3% vs. 16.5%, P c<0.001). The EF was high at 0.57 (RR=9.6, CI 2.9-31.7). In the whole group of patients the frequency of DRBI*11 alleles was low compared with controls (11.4% vs. 32.2%, P =0.02), but was not significant when P was corrected. In conclusion, the DRBI*07011 allele confers susceptibility to a frequently relapsing and steroid-dependent or steroid-resistant course of childhood MCNS. These patterns of the disease seem to have the same immunogenetic components.

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Increased HLA-A*11 in Chinese children with steroid-responsive nephrotic syndrome

Cheung¹,

Ren

Chan

et al. 2002

Pediatr Nephrol

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Human leukocyte antigen (HLA) associations have been frequently reported in childhood steroid-responsive nephrotic syndrome (SRNS) in other populations. The aim of this study was to characterize the immunogenetic background of Singaporean Chinese patients with childhood SRNS. We determined the HLA class I (HLA- A* and HLA-B*) as well as class II (HLA- DRB1*, HLA- DQB1*) gene polymorphisms using the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique, in patients with SRNS (n=64) and normal controls (n=236 for HLA- A*, n=80 for HLA- B*, HLA- DRB1* and HLA- DQB1*). The frequency of HLA- A*11 allele was significantly higher in the SRNS patients compared to controls (78.1% vs 54.2%, respectively; relative risk, RR=3.01, Pc=0.011). However, there was no significant difference in the allele frequencies of HLA- B*, HLA- DRB1* and HLA- DQB1* between the SRNS patients and controls, unlike that in previous studies. Our data suggest that the immunogenetic background of Singaporean Chinese with childhood SRNS was different from that in other populations. As HLA- A*11 has been strongly associated with other autoimmune diseases, it is conceivable that the HLA- A*11-specific motif may play a role in the development of the abnormal T-cell-mediated immune response that may be responsible for triggering the proteinuria seen in SRNS.

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HLA antigens in Arab children with steroid-responsive nephrotic syndrome

Cited by 10 publications

References 5 publications

Is typing for HLA class II alleles beneficial in Indian children with idiopathic nephrotic syndrome?

Is typing for HLA class II alleles beneficial in Indian children with idiopathic nephrotic syndrome?

HLA alleles in frequently relapsing steroid-dependent and -resistant nephrotic syndrome in Egyptian children

Increased HLA-A*11 in Chinese children with steroid-responsive nephrotic syndrome

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