Hla Antigens in Amerindian Groups of Two Different Linguistic Families From Colombia

Abstract

Serological HLA types (A, B, C, DR and DQ loci) were studied in five different Indian tribes (Cubeo, Tucano, Coreguaje, Embera and Noanama) belonging to two distinct linguistic families. For all the MHC loci, the range of variation among the five tribes was enormous. Two tribes, Cubeo and Tucano, showed a wide spectrum of antigenic specificities which seemed to be due to admixture from non-tribal groups, while in the other three tribes the polymorphisms of various HLA loci showed restricted distributions. The gene frequency data, when converted to a kinship matrix and a two-dimensional eigenvector plot, indicated that members of the same linguistic family tend to have greater genetic affinity.

Biological relationship between central and South American Chibchan speaking populations: Evidence from mtDNA

“…DNA was extracted using phenol/chlorform techniques by researcher at the University upon Tyne, UK (Briceñ o et al, 1996a). All 188 samples were characterized for the four major Native American mtDNA haplogroups (A-D) using polymerase chain reaction (PCR) and associated restriction site enzymes (HaeIII, HincII, and AluI) and the presence/absence of the COII-tRNA lys 9-bp deletion.…”

Molecular analysis of HLA‐DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico

“…In recent years, an increasing number of papers have been published describing the HLA class II polymorphisms in several North and South American populations (20–32). All of them show a greatly restricted pattern of HLA class II polymorphism, contrary to what has been shown for class I loci (7,8,12,63).…”

Hla‐dpb 1 Polymorphism in Seven South American Indian Tribes in Colombia

“…Archaeological investigations and studies of several highly polymorphic genetic systems, such as mt-DNA, immunoglobulin allotypes and human leukocyte antigens, have provided some information on the peopling of South America (Torroni et al, 1993;Fernandez-Vina et al, 2992;Salzano & Callegari-Jacques, 1988), but the data on such genetic systems are still limited to a few South American tribes, and data for some geographical areas are very scarce. In Colombia, several Amerindian tribes have recently been investigated for HLA class I and class I1 antigens, using standard microcytotoxicity techniques (Briceno et al, 1996;Bernal et al, 199 1, 1995). New techniques such as polymerase chain reaction (PCR) amplification followed by oligonucleotide hybridization have considerably increased the known range of genetic diversity, especially for class I1 antigens.…”