HLA Antigens in a Scottish Psoriatic Population

Abstract

Sixty‐one patients in the Dundee area suffering from psoriasis were typed for HLA—A and HLA—B antigens. On the basis of the typing results, the patients were divided into three groups, and studied with respect to sex, age of onset and familial incidence of the disease. The frequency of HLA—A1 appeared to be increased and HLA—B7 decreased but HLA—B13 and HLA—B17 were highly significantly increased (P < 10−6 and P < 10−10 respectively) in the psoriatic group compared to 204 controls. Of particular interest was a highly significant association of HLA—A1 with HLA—B17 in psoriatic patients. Family studies showed HLA—B17 to be a useful genetic marker for psoriasis in the families of B17 positive patients. Considerations of age of onset, familial incidence and typing data suggest that there is heterogeneity of genetic susceptibility to psoriasis and that one probable mechanism is the dominant inheritance of a “disease allele” in linkage disequilibrium with the allele coding for HLA—B17.

Meta-analysis of the association between psoriasis and human leucocyte antigen-B

“…Eight of the 19 articles studied the association of HLA‐B*27 with PsV, and the results indicated that the association varied significantly by country. The OR was 3·49 in cases in China, and 1·77 in Germany, 1·19 in Finland, 1·00 in Japan, 0·95 in Scotland, 0·87 in Great Britain, 0·71 in Italy and 0·46 in India . All of the 12 articles concerning PsA reported a positive association between HLA‐B*27 and PsA, with ORs of 2·06–7·45 in Spanish subjects, and 5·80 in Germany, 5·53 in New Zealand, 4·90 in India, 3·51 in Great Britain, 3·03 in the Netherlands, 2·86 in Romania and 1·9 in Sweden .…”

“…Table S3 (see Supporting Information) shows the results of quality assessment. Thirteen studies lacked a definition or diagnosis of psoriasis . Four studies did not report clearly how the patients were selected .…”

Psoriasis vulgaris and human leukocyte antigens

“…The first publications about the association of human leukocyte antigens (HLA) and psoriasis date from the 1970s, yet including population studies on Caucasian, 5–10 and non‐Caucasian patients with psoriasis vulgaris 11 . At that time, serological typing was the only method available and HLA‐B17, HLA‐B13 and HLA‐Cw6 were already considered to be associated with psoriasis vulgaris in Caucasian populations, mainly in the early‐onset type of the disease 12–15 . HLA class II antigens were also studied and an increased frequency of HLA‐DR7 was seen associated with psoriasis by that time 16 .…”

Investigation of the association between psoriasis and human leucocyte antigens A by means of meta‐analysis

“…Table presents the results of quality assessment of the included studies. Eleven articles did not provide the definition or diagnosis of psoriasis . Four articles did not specify the selection of patients .…”

“…Four articles did not specify the selection of patients . In seven articles, the selection criteria for the controls were not explained clearly, or data from blood or organ donors were used as control . Twenty‐two articles did not provide information about age, gender or race of subjects .…”