“…In our hands, the IPI that had been performed in our laboratory for routine testing for nearly 20 years proved to be highly specific and sensitive in the detection of HLA-A, -B, -C and -DR antibodies independent of complement fixation. Sensitivity was much higher than that of an ELISA method (PRA-STAT) and was comparable to CDC in the detection of cytotoxic IgG antibodies [39]. Because the IPI detected non-cytotoxic antibodies as well, the number of positive reactions was clearly higher compared to the CDC.…”