HLA and the Spondyloarthritis

Bruges-Armas, Jácome; Santos, Margarida Rodrigues; Peixoto, Maria Manuela; Couto, Ana Rita; Garrett, Francisco

doi:10.1080/09723757.2004.11885880

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“…Studies have shown that more than 90% of the patients with ankylosing spondylitis have the HLA-B*27 antigen, but only small percent of the subjects that carry the HLA-B*27 antigen will develop ankylosing spondylitis [10]. The prevalence of the HLA-B*27 antigen among healthy Caucasians is between 2% and 18% [11]. High prevalence of HLA-B*27 of 10-50% was found in native Americans, in Africans 4% and Chinese 4-8%.…”

Section: Open    Accessmentioning

confidence: 99%

Association between HLA-A, HLA-C and HLA-B Genes and Ankylosing Spondylitis in Macedonian Population

2012

Maced J Med Sci

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Aim: The aim of this study was to determine the association of HLA-A, -C and -B genes with ankylosing spondylitis in patients from the Republic of Macedonia. Material and Methods:This study included 307 subjects (250 healthy individuals and 57 patients with ankylosing spondylitis who were diagnosed at the University Clinic of Rheumatology in Skopje). The HLA typing of class 1 (HLA-A, HLA-C and HLA-B) genes was performed using the method of Reverse Line Strip, after isolation of DNK from the blood leucocytes with the standard phenol-chloroforme method. The HLA sub typing of HLA-B*27 was performed with high resolution single-strand polymorphism.

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Section: Open    Accessmentioning

confidence: 99%