HLA and hepatitis B infection

Al‐Marri, Ajayeb Al‐Nabet; Batchelor, J. R.

doi:10.1016/s0140-6736(94)90510-x

Cited by 117 publications

(77 citation statements)

References 7 publications

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“…This antigen has been associated with a higher incidence of chronic persistent hepatitis B and unresponsiveness to hepatitis B vaccines, perhaps indicating that the HLA-DR7 phenotype is associated with an inadequate immune response against this virus and possibly others as well. 26,27 In summary, we describe the first case of malignant lymphoma occurring in a patient with PPBL but our molecular analyses do not suggest that bcl-2 or EBV are directly involved in lymphoma genesis. Whether patients with PPBL are indeed at increased risk of hematologic malignancy remains unclear at the present time and will require longer follow-up in more patients.…”

Section: Discussionmentioning

confidence: 80%

Large cell lymphoma complicating persistent polyclonal B cell lymphocytosis

et al. 1998

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Persistent polyclonal B cell lymphocytosis (PPBL) is a rare lymphoproliferative disorder of unclear natural history and its potential for B cell malignancy remains unknown. We describe the case of a 39-year-old female who presented with stage IV-B large cell lymphoma 19 years after an initial diagnosis of PPBL; her disease was rapidly fatal despite intensive chemotherapy and blood stem cell transplantation. Because we had recently identified multiple bcl-2/lg gene rearrangements in blood mononuclear cells of patients with PPBL, we sought evidence of this oncogene in this particular patient: bcl-2/lg gene rearrangements were found in blood mononuclear cells but not in lymphoma cells. Owing to the possible role of Epstein-Barr virus (EBV) in the pathogenesis of PPBL, we also hypothesized our patient might have an EBV-related lymphoproliferative disorder. Despite serologies consistent with past exposure to this virus, it was not found in lymphoma cells using a sensitive polymerase chain reaction technique. We conclude that nonHodgkin's lymphoma may occur during the course of PPBL. However, longer follow-up in more patients will be needed in order to better clarify the risk of hematologic malignancy in patients with PPBL.

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Section: Discussionmentioning

confidence: 80%

Large cell lymphoma complicating persistent polyclonal B cell lymphocytosis

et al. 1998

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“…Between 5% and 20% of individuals infected by the hepatitis B virus develop a chronic carrier state that may be associated with liver disease and hepatocellular carcinoma. It has been found recently that different HLA-DR polymorphisms are associated with either chronic carriage or rates of viral clearance (Almari and Batchelor 1994;Thursz et al 1995).…”

Section: Viral Diseasementioning

confidence: 99%

The Role of Genomics in Studying Genetic Susceptibility to Infectious Disease: Figure 1.

Weatherall

Clegg²,

Kwiatkowski³

1997

Genome Res.

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“…14,15 As with HCV infection, the host immune response to HBV infection determines viral persistence, 16,17 which has been associated with polymorphisms in the human leukocyte antigen complex and other immune response genes. [18][19][20][21][22][23][24] Although there are likely important differences in the mechanisms of HBV persistence, there is also evidence that NK T (NKT) cells play an important role. 25,26 The nonclassical MHC class I chain-related A (MICA) gene encodes a protein that functions as a ligand for NKG2D, an activating receptor on macrophages, CD8 þ T cells, gd T cells, NKT cells, and natural killer NK cells.…”

Section: Introductionmentioning

confidence: 99%

MICA and recovery from hepatitis C virus and hepatitis B virus infections

et al. 2004

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The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8 þ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval ¼ 0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

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HLA and hepatitis B infection

Cited by 117 publications

References 7 publications

Large cell lymphoma complicating persistent polyclonal B cell lymphocytosis

Large cell lymphoma complicating persistent polyclonal B cell lymphocytosis

The Role of Genomics in Studying Genetic Susceptibility to Infectious Disease: Figure 1.

MICA and recovery from hepatitis C virus and hepatitis B virus infections

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