HLA-alloantigen associations in Greek patients with Sjögren's syndrome

Papasteriades, C.; Skopouli, Fotini N.; Drosos, Alexandros A.; Andonopoulos, Andrew P.; Moutsopoulos, Haralampos Μ.

doi:10.1016/0896-8411(88)90079-0

Cited by 47 publications

(29 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, Japanese anti-Ropositive patients with pSS show higher frequencies of HLADRw8 and HLA-DRw52 [38]. and Greek patients with pSS exhibit a high prevalence of HLA-DR5 [39]. Detailed studies oi the patients" sera reactivity with Ro52 peptides in relation to HLA alleles expressed by these patients would help to clarify the present results.…”

Section: Discussionmentioning

confidence: 88%

Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera

Ricchiuti

Briand

Meyer

et al. 1994

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARY The reactivity of autoantibodies present in the sera of 489 palicnts with Sjögren's syndrome (SS), systemic lupus crythematosus (SLE) and other autoimmune diseases was investigated by ELISA using recombinani 52‐kD SSA/Ro protein (rRo52) and 39 overlapping synthetic peptides representing the entire sequence of Ro52. We report that IgG antibodies reacting with rRo52 were present in the sera of a large number of patients with SS (67% of patients with primary SS and 46% of patients with SS associated with SLE), whereas they were less frequent (10‐25%) in SLE, rheumatoid arthritis (RA), juvenile chronic arthritis (JCA) and mixed connective tissue disease (MCTD), and absent in scleroderma. Among the 39 peptides tested, live were recognized by sera from 30‐65% of patients with SS, namely peptides representing residues 2 11, 107 122, 107 126, 277 292 and 365 382. Patients with JCA had raised levels of IgG antibodies reacting with peptides 2 11 and 365 382, and 51% of patients with MCTD had raised levels of IgG antibodies reacting with peptide 365 382. None of the five peptides was recognized by more than 20% of sera from patients with SLE and RA. Interestingly, and of importance in the field of diagnostic tests based on peptides, the reactivity of antibodies to the Ro52 synthetic peptides varied greatly according to the origin of sera. Inhibition experiments using either patients' sera or antibodies induced in rabbits against Ro52 peptides showed that the four domains 2‐11. 107 122, 277 292 and 365 382 are accessible on the surface of the Ro52 protein. These regions may thus be involved in the induction of specific antibodies in autoimmune patients.

show abstract

Section: Discussionmentioning

confidence: 88%

Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera

Ricchiuti

Briand

Meyer

et al. 1994

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…Our results about the somewhat higher prevalence of the HLA-DBR1*11 allele among the persons with SS-A antibodies are also consistent with the findings of some previous studies of HLA in Sjögren's syndrome patients. Namely, in earlier studies it was demonstrated that Greek patients with Sjögren's syndrome frequently possess the HLA-DR5 serotype [18]. Later, HLA-DR5 was split into HLA-DR11 and HLA-DR12, which can be detected by genotyping according to presence of either HLA-DRB1*11 or HLA-DRB1*12 alleles.…”

Section: Discussionmentioning

confidence: 98%

Demonstration of high prevalence of SS-A antibodies in a general population: Association with HLA-DR and enterovirus antibodies

et al. 2006

View full text Add to dashboard Cite

“…In our sample, we detected an increased prevalence of the DRB1*11;DQA1*0501;DQB1*0301 haplotype and alleles in CCHB mothers compared with SLE, but not SS, control mothers. This haplotype has been associated with primary SS in southern European patients (33). Remarkably, the heterozygous combination of DR3; DQ2 and DR11;DQ7 haplotypes seemed to confer an additional risk of giving birth to an affected child in comparison with both anti-Ro-positive control groups.…”

Section: Discussionmentioning

confidence: 99%

DNA typing of maternal HLA in congenital complete heart block: Comparison with systemic lupus erythematosus and primary Sj�gren's syndrome

Colombo

Brucato

Coluccio

et al. 1999

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To investigate which maternal HLA allele or haplotype is primarily associated with isolated congenital complete heart block (CCHB) in offspring.Methods. HLA class II typings were assessed by line probe assay and polymerase chain reactionsequence-specific oligonucleotide probe methods, and HLA class I by the microlymphocytotoxicity test, in 13 Results. HLA-DRB1*03011 and DRB1*03011; DQA1*0501;DQB1*0201 were more frequent in mothers of infants with CCHB than in mothers who had SLE, but not in mothers who had SS and whose children were healthy. Mothers of infants with CCHB were either HLA-B5/35, B17, or B44 positive and had a higher prevalence of B44;DRB11;DQA1*0501;DQB1*0301 and isolated anti-52-kd antibodies, which were absent in SS and SLE controls.Conclusion. Mothers of infants with CCHB presented a strong genetic similarity to mothers who had SS, except for HLA class I phenotype. HLA-DRB1*03011;DQA1*0501;DQB1*0201 seemed not to be primary CCHB-associated genes, but were involved in an SS-like anti-Ro/La response. The combined presence of HLA-DRB1*03011 and anti-52-kd SSA/Ro antibodies conveyed the highest risk of giving birth to an affected child.

show abstract

HLA-alloantigen associations in Greek patients with Sjögren's syndrome

Cited by 47 publications

References 19 publications

Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera

Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera

Demonstration of high prevalence of SS-A antibodies in a general population: Association with HLA-DR and enterovirus antibodies

DNA typing of maternal HLA in congenital complete heart block: Comparison with systemic lupus erythematosus and primary Sj�gren's syndrome

Contact Info

Product

Resources

About