HLA-A2 expression, stage, and survival in colorectal cancer

Kiewe, Philipp; Mansmann, Veit; Scheibenbogen, Carmen; Buhr, H. J.; Thiel, Eckhard; Nagorsen, Dirk

doi:10.1007/s00384-008-0488-y

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…Our results conflict with the study by Kiewe et al who found no statistically significant difference in 5-year survival and overall survival between HLA-A2-positive and HLA-A2--negative groups of patients with colorectal cancer [2]. One possible explanation for these differences might be differences in the patient cohort.…”

Section: Discussioncontrasting

confidence: 99%

“…This percentage is slightly higher than the prevalence of HLA-A2 antigens in the Caucasian population in Central and Western Europe, which is around 45% (42.6-51.3%), and also higher than in the results of the study by Kiewe et al who found a frequency of exactly 50% of HLA-A2 expression. [2] However, these findings are not statistically significant.…”

Section: Discussionmentioning

confidence: 81%

“…HLA class I antigens are integral membrane glycoproteins that are inherited and expressed at varying levels on the surface of virtually all somatic cells [1]. It is known that HLA-A2 (MHC class I) is common among Caucasians (approximately 45% of the Caucasian population) [2] and that some antigens characteristic for colorectal cancer (CRC) are presented in its context. These include CSNK1A1, GAS7, HAUS3, SRPX, WDR46, ERBB2, AKAP13, and MUC1 antigens.…”

Section: Statisticsmentioning

confidence: 99%

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The prognostic significance of HLA-A2 expression on somatic cells in patients with left-sided colon and rectal cancers

Dyląg-Trojanowska¹,

Pach

Siedlar

et al. 2020

Nowotwory. Journal of Oncology

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Introduction. Current knowledge about colorectal cancer (CRC) identifies tumor immunogenicity as one of the more important issues. In cancers, a prerequisite for immune system activation is the presentation of tumor associated antigen (TAA) epitopes to immunocompetent cells. HLA-A2 is one of the antigens in the context of which TAAs are present, but data on the possible impact of HLA-A2 antigen expression on the survival of patients with colorectal cancer are scarce and sometimes contradictory. The aim of this study was to analyse the relationship between HLA-A2 expression in patients with left-sided colorectal cancer in various stages of disease and their long-term survival, and to answer the question of whether a lack of HLA-A2 expression is actually a negative prognostic factor. Material and methods. A prospective analysis of 58 patients with left-sided colorectal cancer was carried out. Expression of HLA-A2 was determined by patient blood lymphocyte staining, and analysed using flow cytometry. Results. In the study group, patients with HLA-A2 expression lived statistically longer than HLA-A2 negative patients (p = 0.027). There was no significant difference in overall survival between the HLA-A2+ and HLA-A2-groups with stage II and III left-sided CRC. However, the Cox proportional hazard model showed that a lack of HLA-A2 expression was a negative prognostic factor in the group of radically operated patients without distant metastases. Conclusions. HLA-A2 status may affect the clinical course of patients with left-sided colon and rectal cancer, although left-sided tumors are less immunogenic than right-sided ones. HLA-A2-positive patients with left-sided colorectal cancer lived statistically longer than those who were HLA-A2-negative (p = 0.027). Lack of HLA-A2 expression was a negative prognostic factor in the group of radically operated patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 81%

Section: Statisticsmentioning

confidence: 99%

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The prognostic significance of HLA-A2 expression on somatic cells in patients with left-sided colon and rectal cancers

Dyląg-Trojanowska¹,

Pach

Siedlar

et al. 2020

Nowotwory. Journal of Oncology

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“…It is noteworthy that in our study the functionality of intratumoral T cells was not analyzed, since this study focused on the HLA-I/APM expression pattern. In contrast to the general dogma, patients with a HLA-I discordant high/low phenotype had a significant better prognosis compared to the HLA-I high phenotype, which is in line with a report in CRC, in which HLA-A2-positive patients had a poorer tumor differentiation [51]. However, most important finding in this context is limited (T1/T2) tumor disease suggesting that the tumor burden might play a key role in the stage dependent immunological control of OSCC.…”

Section: Discussionsupporting

confidence: 89%

Tumoral HLA Class I and APM Expression and Its Effect on Intratumoral T-cell Reaction and Outcome in HPV-Negative Oral Squamous Cell Carcinoma

Wickenhauser¹,

Bethmann²,

Kappler³

et al. 2020

Preprint

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Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape of tumor cells from the host immune surveillance with growing evidence of its underlying molecular mechanisms and its interaction with the immune cell control. In this study the expression of HLA class I (HLA-I) antigens and of components of the antigen processing machinery (APM) was analyzed in 160 consecutive human papilloma virus (HPV)-negative OSCC lesions and correlated to tumor specific parameters, the intratumoral immune cell response and to the patients outcome. A heterogeneous, but predominantly lower constitutive protein expression of HLA-I APM components was seen in OSCC sections when compared to non-neoplastic cells. Based on the expression levels of HLA-I APM components three main OSCC subgroups were detected and categorized into HLA-Ihigh/APMhigh, HLA-Ilow/APMlow and HLA-Idiscordant high/low/APMhigh phenotypes. In the HLA-Ihigh/APMhigh group, the highest frequency of intratumoral CD8+ T cells and lowest number of CD8+ T cells close to FoxP3 cells was found. Despite being associated with the highest T cell infiltration, patients within this group presented the most unfavorable survival, which was most evident in stage T2 tumors. Thus, the presented findings strongly indicate the presence of additional factors involved in the immunomodulatory process of HPV-negative OSCC with a possible tumor-burden-dependent complex network of immune escape mechanisms beyond HLA-I/APM components and T cell infiltration in this tumor entity.

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“…Here, we has further confirmed the involvement of HLA-A2 in breast cancer as significant higher expression of HLA-A2/A30 and HLA-A2/A31 haplotype as well as HLA-A30 and A31 alleles in breast cancer patients were reported (Table 3). HLA-A2 has been associated with poor disease outcome in breast [18,21], lung [22], ovarian [23], colorectal [24] and gastric cancer [8,25]. HLA-A2 ?…”

Section: Discussionmentioning

confidence: 99%

HLA-A and breast cancer in West Peninsular Malaysia

et al. 2010

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Breast cancer is the most common malignancy among females in Malaysia. Attempts have been made to investigate the association between breast cancer and human leukocyte antigen (HLA) types. However, data from those previous studies are highly variable. The aim of this study is to investigate the association between HLA-A types and clinicopathological factors in breast cancer. The frequencies of HLA-A type in 59 female patients with infiltrating ductal of the breast were determined by polymerase chain reaction method. HLA-A2/A30 and A2/A31 haplotype (5.1%; P = 0.045) as well as HLA-A30 (5.1%, P = 0.045) and A31 (6.8%; P = 0.020) allele were significant higher in the patients than controls (0%). HLA-A24 allele was negatively related to lymph node metastasis (r = -0.316; P = 0.021) whereas, A26 (r = -0.430; P = 0.001) and A36 (r = -0.430; P = 0.001) alleles were negatively correlated to distant metastasis in breast cancer. Negative correlations between HLA-A26/A36 (r = -0.430; P = 0.001), A2/A11 (r = -0.276; P = 0.044), A24/A34 (r = -0.430; P = 0.001) haplotypes and distant metastasis were identified. Interestingly, Her2 expression in breast carcinoma was negatively correlated to A11/24 haplotypes (r = -0.294; P = 0.034) but positively correlated to homozygous HLA-A24 (r = 0.396; P = 0.040). In conclusion, HLA-A2, -A30 and A31 were associated with breast cancer.

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HLA-A2 expression, stage, and survival in colorectal cancer

Cited by 10 publications

References 21 publications

The prognostic significance of HLA-A2 expression on somatic cells in patients with left-sided colon and rectal cancers

The prognostic significance of HLA-A2 expression on somatic cells in patients with left-sided colon and rectal cancers

Tumoral HLA Class I and APM Expression and Its Effect on Intratumoral T-cell Reaction and Outcome in HPV-Negative Oral Squamous Cell Carcinoma

HLA-A and breast cancer in West Peninsular Malaysia

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