HLA-A, -B, -DRB1 and -DQB1 polymorphisms among Iraqi Arabs

Ad’hiah, Ali H.; Al-rikabi, Aaiad H.; Ahmed, Zahra'a A.; Kamil, Liath A.

doi:10.1016/j.humimm.2020.03.006

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…In Iraq, frequency of the three alleles was only available for females; it was 5.2, 17.0, and 9.4%, respectively [27]. Inbreeding could theoretically lead to elevated frequencies of G*01:04 and G*01:05N alleles, because Iraqis generally obey some traditional practices (i.e., high prevalence of consanguineous marriage), which may influence HLA allele frequencies [28]. The present study sought to investigate the role of G*01:04 and G*01:05N alleles in genetic susceptibility to IBD in UC and CD patients.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of HLA-G gene (G01:03, G01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Abdul-Hussein¹,

Ali²,

Zaki³

et al. 2021

Egypt J Med Hum Genet

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Background Human leukocyte antigen-G (HLA-G) has been proposed to influence susceptibility to inflammatory bowel disease (IBD). Therefore, the genetic association between HLA-G alleles and two clinical phenotypes of IBD (ulcerative colitis [UC] and Crohn’s disease [CD]) was evaluated in Iraqi patients. A case-control study was performed on 50 UC and 50 CD patients and 100 healthy controls (HC). Three HLA-G alleles (G*01:03, G*01:04, and G*01:05N) were determined using sequence-specific polymerase chain reaction assay followed by product digestion with restriction endonucleases (Hinf-I, BseR-I, and PpuM-I, respectively). Results The G*01:03 allele was not detected in IBD patients (UC and CD) or HC, while G*01:04 and G*01:05N alleles showed polymorphic frequencies. The allele G*01:04 was significantly associated with susceptibility to UC (odds ratio [OR] = 2.55; 95% confidence interval [CI] = 1.27–5.13; corrected probability [pc] = 0.018) and CD (OR = 4.45; 95% CI = 2.11–9.41; pc < 0.001). The allele G*01:05N was also associated with increased risk of UC (OR = 4.17; 95% CI = 1.32–13.21; pc = 0.032) and CD (OR = 4.75; 95% CI = 1.53–14.78; pc = 0.014). These associations were more pronounced in IBD (UC + CD), and a significantly increased risk for IBD was found with the alleles G*01:04 (OR = 3.32; 95% CI = 1.86–5.95; pc < 0.001) and G*01:05N (OR = 4.46; 95% CI = 1.59–12.47; pc = 0.008). A stratification of IBD patients according to some demographic and clinical characteristics revealed that frequencies of both alleles showed no significant differences between the subgroups of patients in each stratum. Soluble HLA-G was not influenced by HLA-G alleles in patients or HC. UC was an exception, and the presence of G*01:04 allele was associated with a significantly higher mean of soluble HLA-G compared to patients without the allele (189.6 ± 24.0 vs. 168.6 ± 27.2 ng/mL; p = 0.033). Conclusion This study indicated that HLA-G*01:04 and HLA-G*01:05N alleles may influence susceptibility to UC and CD in Iraqi patients.

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of HLA-G gene (G01:03, G01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Abdul-Hussein¹,

Ali²,

Zaki³

et al. 2021

Egypt J Med Hum Genet

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The Influence of TNF-α, IL-6, TGF-β1, IFN-γ, IL-10 Polymorphisms on Predisposition to Diabetes Mellitus among Jordanian Patients

Khdair

Al-Naimat

Jarrar

et al. 2023

EMIDDT

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Background: Diabetes mellitus is a long-term disorder with high prevalence globally. It can be classified into two types: Type 1 diabetes and Type 2 diabetes mellitus. Diabetes mellitus is considered a multifactorial disorder in which genetic factors such as cytokines play a major role. Cytokines play a role is immune modulation and are associated with the development of diabetes mellitus. Single nucleotide polymorphisms in cytokines were studied extensively in different populations to determine their association with predisposition to diabetes mellitus. Objective: The aim of this study was to estimate the frequency of single nucleotide polymorphisms in the cytokine genes TNF-α, TGF-β, IL-6, IL-10, and INF-γ in 102 Jordanian diabetes mellitus patients in comparison to 50 controls and their association to diabetes mellitus susceptibility. Objective: The aim of this study was to estimate the frequency of single nucleotide polymorphisms in the cytokine genes TNF-α, TGF-β, IL-6, IL-10, and INF-γ in 102 Jordanian diabetes mellitus patients in comparison to 50 controls and their association to diabetes mellitus susceptibility. Methods: Analysis was performed using the highly specific polymerase chain reaction-sequence specific primers methodology Results: Our findings showed that the IL-10-1082 G/G genotype (P=0.02) and the TGF-β1 codon 25*G allele (P<0.01) may be considered risk factors for type 2 diabetes mellitus. In addition, the IFN- γ -874*A allele (P=0.04) seems to increase the predisposition to type 1 diabetes. Conclusion: Our study showed that the IL-10-1082 G/G genotype and TGF-β1 codon 25*G allele are associated with type 2 diabetes mellitus while the IFN- γ -874*A allele is associated with type 1 diabetes. Our findings may help in the early detection of diabetes mellitus which would in turn help in undergoing the needed preventative measures to delay the onset of diabetes mellitus

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The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation

et al. 2022

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HLA-A, -B, -DRB1 and -DQB1 polymorphisms among Iraqi Arabs

Cited by 3 publications

References 6 publications

Genetic polymorphism of HLA-G gene (G01:03, G01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Genetic polymorphism of HLA-G gene (G01:03, G01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

The Influence of TNF-α, IL-6, TGF-β1, IFN-γ, IL-10 Polymorphisms on Predisposition to Diabetes Mellitus among Jordanian Patients

The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation

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HLA-A, -B, -DRB1 and -DQB1 polymorphisms among Iraqi Arabs

Cited by 3 publications

References 6 publications

Genetic polymorphism of HLA-G gene (G*01:03, G*01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Genetic polymorphism of HLA-G gene (G*01:03, G*01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

The Influence of TNF-α, IL-6, TGF-β1, IFN-γ, IL-10 Polymorphisms on Predisposition to Diabetes Mellitus among Jordanian Patients

The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation

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Product

Resources

About

Genetic polymorphism of HLA-G gene (G01:03, G01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Genetic polymorphism of HLA-G gene (G01:03, G01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)