HLA-A, -B, -DRB1 Alleles as Genetic Predictive Factors for Dengue Disease: A Systematic Review and Meta-Analysis

Chen, Yuan; Liao, Yuning; Yuan, Kangzhuang; Wu, Aiwu; Liu, Lidong

doi:10.1089/vim.2018.0151

Cited by 8 publications

(3 citation statements)

References 46 publications

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“…Notwithstanding, the conclusions went hand in hand with the study limitations that formed the body of evidence, say the combination of DHF and DSS or late measurement [12,14,19,22,23]. Besides, studies have focused concern on immunogenetic markers that benefit pathophysiology rather than medical case management [18,[24][25][26][27]. Here we advance the findings of prior work to illustrate the association of available markers and severe dengue in a different context.…”

Section: Introductionmentioning

confidence: 69%

Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

et al. 2021

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Background Predictive markers represent a solution for the proactive management of severe dengue. Despite the low mortality rate resulting from severe cases, dengue requires constant examination and round-the-clock nursing care due to the unpredictable progression of complications, posing a burden on clinical triage and material resources. Accordingly, identifying markers that allow for predicting disease prognosis from the initial diagnosis is needed. Given the improved pathogenesis understanding, myriad candidates have been proposed to be associated with severe dengue progression. Thus, we aim to review the relationship between the available biomarkers and severe dengue. Methodology We performed a systematic review and meta-analysis to compare the differences in host data collected within 72 hours of fever onset amongst the different disease severity levels. We searched nine bibliographic databases without restrictive criteria of language and publication date. We assessed risk of bias and graded robustness of evidence using NHLBI quality assessments and GRADE, respectively. This study protocol is registered in PROSPERO (CRD42018104495). Principal findings Of 4000 records found, 40 studies for qualitative synthesis, 19 for meta-analysis. We identified 108 host and viral markers collected within 72 hours of fever onset from 6160 laboratory-confirmed dengue cases, including hematopoietic parameters, biochemical substances, clinical symptoms, immune mediators, viral particles, and host genes. Overall, inconsistent case classifications explained substantial heterogeneity, and meta-analyses lacked statistical power. Still, moderate-certainty evidence indicated significantly lower platelet counts (SMD -0.65, 95% CI -0.97 to -0.32) and higher AST levels (SMD 0.87, 95% CI 0.36 to 1.38) in severe cases when compared to non-severe dengue during this time window. Conclusion The findings suggest that alterations of platelet count and AST level—in the first 72 hours of fever onset—are independent markers predicting the development of severe dengue.

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Section: Introductionmentioning

confidence: 69%

Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

et al. 2021

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“…Additional HLA typing and statistical inference of HLA alleles can refine the SNP association signals to specific HLA alleles, reflecting specific molecular functions and pathways. Such a strategy was successfully implemented for infectious diseases such as HIV, HPV, Dengue, and Ebola ( Lin et al, 2003 ; Wang et al, 2011 ; Nishida et al, 2016 ; Adebamowo and Adeyemo, 2019 ; Chen et al, 2019 ; Ekenberg et al, 2019 ; Butler-Laporte et al, 2020 ; Chaisri et al, 2020 ; Huang et al, 2020 ; Ursu et al, 2020 ; Yengo et al, 2020 ).…”

Section: The Role Of Immunogenetics In Infectious Diseasesmentioning

confidence: 99%

Current HLA Investigations on SARS-CoV-2 and Perspectives

et al. 2021

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The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.

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“…The profound expansion of DENV-specific memory T cells (from the first infection) with a low affinity with the infecting DENV serotype may contribute to delayed viral clearance and the enhanced release of proinflammatory cytokines, leading to more severe manifestations [ 20 , 26 , 27 , 28 ]. Polymorphisms in genes related to innate and adaptive (humoral and cellular) immune responses, as well as cytokine and chemokine genes, have been shown to influence the susceptibility to DHF/DSS or severe dengue [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Dengue and the Lectin Pathway of the Complement System

Kraivong

Punyadee

Liszewski

et al. 2021

Viruses

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Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4). Usually, the primary infection is asymptomatic or causes mild dengue fever (DF), while secondary infections with a different serotype increase the risk of severe dengue disease (dengue hemorrhagic fever, DHF). Complement system activation induces inflammation and tissue injury, contributing to disease pathogenesis. However, in asymptomatic or primary infections, protective immunity largely results from the complement system’s lectin pathway (LP), which is activated through foreign glycan recognition. Differences in N-glycans displayed on the DENV envelope membrane influence the lectin pattern recognition receptor (PRR) binding efficiency. The important PRR, mannan binding lectin (MBL), mediates DENV neutralization through (1) a complement activation-independent mechanism via direct MBL glycan recognition, thereby inhibiting DENV attachment to host target cells, or (2) a complement activation-dependent mechanism following the attachment of complement opsonins C3b and C4b to virion surfaces. The serum concentrations of lectin PRRs and their polymorphisms influence these LP activities. Conversely, to escape the LP attack and enhance the infectivity, DENV utilizes the secreted form of nonstructural protein 1 (sNS1) to counteract the MBL effects, thereby increasing viral survival and dissemination.

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HLA-A, -B, -DRB1 Alleles as Genetic Predictive Factors for Dengue Disease: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 46 publications

Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

Current HLA Investigations on SARS-CoV-2 and Perspectives

Dengue and the Lectin Pathway of the Complement System

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