HLA-A, -B, -Cw and -DRB1 alleles, KIR alleles and Cytokine polymorphisms in a population from Northern Ireland

Williams, F.; Middleton, D.

doi:10.1016/j.humimm.2004.08.060

Cited by 4 publications

(11 citation statements)

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“…The populations of Western and Central European origin, such as Scottish (Tonks et al. , 2004), North Irish (Williams & Middleton, 2004), Welsh (Darke et al. , 1998), German (Ferencik & Gross‐Wilde, 2004), French South East (Dubois & Gebuhrer, 2004), Spanish (Crespi et al.…”

Section: Resultsmentioning

confidence: 99%

“…, 1998; Dubois & Gebuhrer, 2004; Ferencik & Gross‐Wilde, 2004;Tonks et al. , 2004; Williams & Middleton, 2004; Zahlavova et al. , 2004).…”

Section: Discussionunclassified

“…, 1998; Ferencik & Gross‐Wilde, 2004; Tonks et al. , 2004; Williams & Middleton, 2004; Zahlavova et al. , 2004), where HLA‐DRB1*11 is generally found with a frequency <10%, except for the Southeast French population, where it is the second most frequent DRB1* allele after DRB1*13 (Dubois & Gebuhrer, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…, 2002; Ferencik & Gross‐Wilde, 2004; Tonks et al. , 2004; Williams & Middleton, 2004). Interestingly 12 haplotypes occurred at a frequency of >1% with a cumulative frequency of 22.45%.…”

Section: Discussionmentioning

confidence: 99%

“…The HLA allele frequency data used for interpopulation comparisons were taken from D. Middleton's Website http://www.allelefrequencies.net (Middleton et al, 2003). These data were compared with the corresponding published data when available (Goldberg et al, 1997;Darke et al, 1998;Crespi et al, 2002;Ivanova et al, 2002;Mohyuddin et al, 2002;Spínola et al, 2002;Arnaiz-Villena et al, 2004;Dubois & Gebuhrer, 2004;Ferencik & Gross-Wilde, 2004;Pyo et al, 2004;Rendine et al, 2004;Sanchez-Velasco et al, 2004;Saruhan-Direskeneli & Ugar, 2004;Suciu-Foca et al, 2004;Tonks et al, 2004;Williams & Middleton, 2004;Zahlavova et al, 2004;Ke-Ming et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

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HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

Sulçebe

Sanchez‐Mazas

et al. 2009

Int J Immunogenetics

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Human leucocyte antigen (HLA) alleles are very interesting markers in identifying population relationships. Moreover, their frequency distribution data are important in the implementation of donor-recipient registry programs for transplantation purposes and also in determining the genetic predisposition for many diseases. For these reasons, we studied the HLA class I and II allele and haplotype frequencies in 160 healthy, unrelated Albanian individuals originating from all regions of the country. The HLA genotyping was performed through a 2-digit resolution SSOP method. The data were analysed with Arlequin and Phylip programs. No deviation was found from the Hardy-Weinberg equilibrium. A total of 17 A*, 30 B*, 12 Cw*, 13 DRB1* and 5 DQB1* alleles were identified. The six most frequent HLA-A-B-DRB1 haplotypes were A*02-B*18-DRB1*11 (5.60%), A*02-B*51-DRB1*16 (4.74%), A*01-B*08-DRB1*03 (3.48%), A*24-B*35-DRB1*11 (2.77%), A*02-B*51-DRB1*13 (2.21%), A*24-B*35-DRB1*14 (1.89%). Interestingly, 12 HLA-A-B-Cw-DRB1-DQB1 haplotypes occurred at a frequency >1%. When compared with the other populations, a close relationship was found with North Greek, Bulgarian, Macedonian, Romanian, Turkish, Cretan, Serbian, Croatian and Italian populations. A higher differentiation in allele frequency level was found with Western Europe populations. These data are the first report of HLA allele and haplotype distribution in an Albanian population inside this country. When compared with other populations, their distribution frequencies show close similarities with neighbouring populations of the entire Balkan area.

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Section: Resultsmentioning

confidence: 99%

“…, 1998; Dubois & Gebuhrer, 2004; Ferencik & Gross‐Wilde, 2004;Tonks et al. , 2004; Williams & Middleton, 2004; Zahlavova et al. , 2004).…”

Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

“…, 2002; Ferencik & Gross‐Wilde, 2004; Tonks et al. , 2004; Williams & Middleton, 2004). Interestingly 12 haplotypes occurred at a frequency of >1% with a cumulative frequency of 22.45%.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

Sulçebe

Sanchez‐Mazas

et al. 2009

Int J Immunogenetics

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HLA‐C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India–Pakistan

et al. 2006

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Lebanon is located at a continental crossroad between Europe, Africa, and Asia. This region has been the center of wide-scale movements of populations as well as the theater of genetic and cultural trade off among neighboring populations. In this study, HLA-C alleles were characterized by a PCR-SSOP (sequence-specific oligonucleotide probes) hybridization protocol in a sample of 97 Lebanese. A total of 23 alleles were identified with four predominant, Cw*0401, Cw*0602, Cw*0701/06, and Cw*1203, accounting for almost 60% of HLA-C allele frequencies. We included the Lebanese data into a broad analysis of the HLA-C genetic structure of a large set of populations located in Europe, the Middle East, and the Indian subcontinent. Our results indicate that Lebanese exhibit an intermediate genetic profile among the populations from the Middle East, which constitute a rather homogeneous genetic group. In Europe, a high correlation coefficient is found between genetic and geographic distances. In this continent, we also identified a significant genetic frontier following a north-east to south-west axis. This frontier cuts through the Alps and the Pyrenees, thus separating the north-western European populations from those located in the eastern and Mediterranean areas. Finally, the populations from India - Pakistan are very heterogeneous, particularly the Dravidians. Their differentiation has probably been caused by rapid genetic drift under complex influences of cultural, linguistic, and/or religious barriers. Overall, the results show that the HLA-C genetic patterns of these three geographic regions, i.e., the Middle East, Europe, and India-Pakistan, have been shaped by very different genetic histories.

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A crypto‐Dravidian origin for the nontribal communities of South India based on human leukocyte antigen class I diversity

2006

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The Dravidian communities are considered to be the original inhabitants of India, now restricted to South India. The southern most state, Kerala, is socio-culturally stratified into Hindus, Muslims and Christians on the basis of religion. The origin of these religious communities in Kerala is considered to be unique in comparison with that in other parts of the country. These communities were later influenced by the hierarchical caste structure established by the Hindu Brahmins. In the present study, we compared six nontribal (Namboothiri, Nair, Ezhava, Pulaya, Malabar Muslim and Syrian Christian) communities belonging to the major religious groups in Kerala (Hindu, Muslim and Christian) based on the human leukocyte antigen (HLA)-A, -B and -C diversity. Our aim was to understand the genomic substructuring associated with the changing social scenario in various caste and religious groups and compare it with the Dravidian tribal and other world populations. The present study reveals that the HLA diversity of the Dravidian communities is very distinct from that in the other world populations. It is obvious that the nontribal communities of Kerala display a greater Dravidian influence, but traces of genetic admixture with the Mediterranean, western European, central Asian and East Asian populations can be observed. This characterizes the crypto-Dravidian features of the nontribal communities of Kerala. Demic diffusion of the local progressive communities with the migrant communities may have given rise to crypto-Dravidian features among the nontribal communities of Kerala.

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HLA-A, -B, -Cw and -DRB1 alleles, KIR alleles and Cytokine polymorphisms in a population from Northern Ireland

Cited by 4 publications

References 0 publications

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

HLA‐C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India–Pakistan

A crypto‐Dravidian origin for the nontribal communities of South India based on human leukocyte antigen class I diversity

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