HLA‐A,B,C and DR antigens in a sample of the Tunisian population

Ayed, K; Bardi, R.; Gebuhrer, L.; Gorgi, Y.; Bétuel, H

doi:10.1111/j.1399-0039.1987.tb01581.x

Cited by 19 publications

(3 citation statements)

References 8 publications

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“…Taken together the current data cannot allow us to confirm the absence of predominant haplotype in the population of Casablanca. The genetic distance data confirm previous studies [6][7][8][9][10][11][12][13][14][15] and show that Moroccans are closely related to Maghrebian but far from Senegalese and Moroccan Jewish.…”

Section: Discussionsupporting

confidence: 89%

Polymorphism of human leukocyte antigen-A, -B, and -DRB1 in a Moroccan population from Casablanca: study of the allelic and the haplotypic frequencies

Kabbaj

Oudghiri²,

Naya³

et al. 2011

Annales De Biologie Clinique

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Nous avons étudié la distribution des allèles et des haplotypes des antigènes HLA-A,-B et DRB1 dans un échantillon de 125 individus marocains non apparentés sains qui sont originaires de Casablanca, et ce par amplification de séquences d'oligonucléotides spécifiques. La ville marocaine, Casablanca, est connue par sa forte mixité et diversité ethnique, surtout arabes et berbères. Les allèles les plus fréquemment rencontrées sont les suivantes : HLA-A*02 (18,4 %),-A*01 (11,2 %),-A*03 (10,8 %),-B*51 (8,06 %),-B*44 (7,66 %),-B*08 (6,85 %),-DRB1*04 (15.98 %),-DRB1*03 et-DRB1*07 (13,92 %) et-DRB1*01 (10 %). De hautes fréquences d'haplotypes à deux locus ont été observées pour: A*03-B*51 (5 %), A*02-DRB1*03 (5.5 %), A*02-DRB1*04 et A*01-DRB1*04 (5 %) et B*35-DRB1*04 (4 %). Aucun haplotype à trois locus dominant n'a été observée pour HLA-A-B-DRB1. Nos résultats confirment et élargissent les connaissances actuelles sur la structure génétique des marocains de Casablanca. Cette étude servira de référence pour de nouvelles études anthropologiques, ainsi que des études de HLA et les associations de la maladie dans la population marocaine.

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Section: Discussionsupporting

confidence: 89%

Polymorphism of human leukocyte antigen-A, -B, and -DRB1 in a Moroccan population from Casablanca: study of the allelic and the haplotypic frequencies

Kabbaj

Oudghiri²,

Naya³

et al. 2011

Annales De Biologie Clinique

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“…Several studies have been devoted to the analysis of HLA‐DRB1 and DQB1 in North African populations, namely Moroccan and Algerian Berbers and Arabs (Djoulah et al ., 1994; Arnaiz‐Villena et al ., 1995;Izaabel et al ., 1996), Egyptians (Hafez & El Chennawi, 1986; El Chenawi et al ., 1996) and Tunisians (Ayed et al ., 1987; Jenhani et al ., 1989; Hmida et al ., 1995). However, no Berber population was ever investigated in Tunisia despite the presence of many Berber communities.…”

Section: Introductionmentioning

confidence: 99%

HLA class II genetic diversity in southern Tunisia and the Mediterranean area

Guenounou

Yacoubi-Loueslati

Bühler

et al. 2006

Int J Immunogenetics

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North Africa is populated by many Arab- and Berber-speaking populations whose genetic history is still poorly understood. In this study, we analyse the HLA-DRB1 and DQB1 molecular diversity in three populations from the south of Tunisia--Berbers from Jerba, Berbers from Matmata and Arabs from Gabes--and we compare them to a large set of populations from the whole Mediterranean region. Among the three populations studied, the Berbers from Jerba are the most peculiar, as they diverge significantly from other North Africans while being genetically highly diversified and close to populations from the Near East. Thus, Jerba may have been a crossing point, in historical times, where colonization from the eastern Mediterranean area left significant genetic traces. By contrast, the populations from Matmata and Gabes are genetically similar to other Arab and Berber-speaking populations from different areas of the Maghrib, despite some peculiar allele and haplotype frequencies. At a larger scale, northwest Africa and southwest Europe are closely related according to these polymorphisms, while the populations from the eastern Mediterranean area are much more differentiated. The close genetic relatedness found for HLA among populations of the western Mediterranean region challenges previous results based on Y chromosome analyses, where the Gibraltar Strait appeared to constitute a main genetic barrier.

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“…A possible cumulative effect on VTE risk by the simultaneous transmission of the major genetic traits mentioned above has been supported by some studies (14,15) but not by other recent reports (16,17). Previous immunogenetic studies showed that Tunisian population was composed of a mixture of different ethnicities as a result of active movement of population (18,19). However, there are no reports to date associating the four genetic prothrombotic traits, nor their thrombosis relevance.…”

Section: Introductionmentioning

confidence: 97%

Factor V Leiden, Prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and Homocysteinemia in Tunisian Blood Donors

Hadhri

Rejab

Guedria

et al. 2012

Clinical Laboratory Analysis

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Specific genetic conditions are known to be associated with high risk of venous thromboembolism. This genetic basis varies widely between ethnic groups. We investigated the distribution of four inherited polymorphisms in 113 unselected Tunisian blood donors by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The allele frequencies of Factor V Leiden (FVL), prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 677C>T, and MTHFR 1298A>C mutations were 3, 0.9, 30, and 31%, respectively. The MTHFR 677C>T polymorphism was influenced by age. Twenty-nine of the 113 blood donors demonstrated more than one genetic markers. Hyperhomocysteinemia was found in 12 subjects, and it was statistically associated to the MTHFR 677TT genotype. Principal component analysis allowed disclosing the resemblance between Mediterranean populations. Our findings may be helpful for population genetics study, and provide epidemiologic database for further studies in thrombosis field among Tunisians.

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HLA‐A,B,C and DR antigens in a sample of the Tunisian population

Cited by 19 publications

References 8 publications

Polymorphism of human leukocyte antigen-A, -B, and -DRB1 in a Moroccan population from Casablanca: study of the allelic and the haplotypic frequencies

Polymorphism of human leukocyte antigen-A, -B, and -DRB1 in a Moroccan population from Casablanca: study of the allelic and the haplotypic frequencies

HLA class II genetic diversity in southern Tunisia and the Mediterranean area

Factor V Leiden, Prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and Homocysteinemia in Tunisian Blood Donors

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