HLA-A and HLA-B gene polymorphism and idiopathic pulmonary fibrosis in a Han Chinese population

Abstract

These data suggest that the gene frequency of HLA-A*3, HLA-B*14, -B*15, -B*40, and the linked gene frequency of HLA-A2B15, -A2B40, -A11B15, -A24B58, -A30B40 is associated with IPF pathogenesis.

Mucin 5B Promoter Polymorphism Is Associated with Susceptibility to Interstitial Lung Diseases in Chinese Males

“…In Asian populations, polymorphisms of the genes encoding for cytokines IL-3 and TGF-β[27], [28] could affect the susceptibility to IPF. HLA-A and HLA-B immune gene polymorphisms [12] were suggested to be associated with IPF in the Korean population. To date, no information is available regarding the putative association between MUC5B rs35705950 and fibrotic lung disease in the Chinese population.…”

Association of HLA and cytokine gene polymorphisms with idiopathic pulmonary fibrosis

“…In addition, a study by Zhang et al [13] showed that HLA‐A*3, B*14, B*15, and B*40 were more prevalent in IPF patients from the same racial group. However, the present study did not validate any of these alleles.…”

“…In particular, the association between HLA genes and the relative risk for IPF has been investigated in several populations. However, studies on the possible role of HLA in IPF susceptibility are fewer and with contradictory findings [12–14,33]. The contradictory results may be attributed to the different ethnic and heritage backgrounds of the study populations [34].…”

“…Three studies reported the average allele frequencies of HLA‐A*3, B*14, B*15, and B*40 were 3.18, 0.36, 13.00, and 14.76 respectively from a total of 17,533 Chinese Han donors [35–37]. Obviously, these allele frequencies are high in the normal Chinese population, but not so low in Zhang et al's [13] report, especially in regards to the HLA‐B*15 and B*40 alleles. We speculate that this is the reason why our results did not corroborate the findings of Zhang et al [13].…”

“…Patients with immunological disorders often have an abnormal distribution of HLA alleles and haplotypes [10,11]. Interestingly, several studies have shown that people with certain HLA polymorphisms have a higher susceptibility for IPF [12–14]. However, another study indicated that HLA is not associated with IPF [15].…”