HL‐A in Hodgkin's Disease. III. A Prospective Study

Kissmeyer-Nielsen, F; Kjerbye, K. E.; Lamm, L. U.

doi:10.1111/j.1600-065x.1975.tb01558.x

Cited by 6 publications

(9 citation statements)

References 2 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Hla Class Imentioning

confidence: 99%

“…Nine studies (including case-control and secondary analytic studies) based on either genotyping or serological methodologies have replicated the HLA-A*01 association with HL risk and allele [79,[103][104][105][106][107][108][109][110]. In five of these studies, the HLA-A*01 association was specific to MCHL risk [106] or EBV-positive HL risk [79,103,108,109]. A number of other HLA class I alleles have also been reported to increase HL risk, including HLA-B*05 [104,105], HLA-B*08 [104][105][106]111] and HLA-B*37 [108,109,112], while HLA-A*02 [79,103,108], HLA-A*03 [104] and HLA-A*11 [105] have been associated with decreased risk (Table S2).…”

Section: Hla Class Imentioning

confidence: 99%

“…In five of these studies, the HLA-A*01 association was specific to MCHL risk [106] or EBV-positive HL risk [79,103,108,109]. A number of other HLA class I alleles have also been reported to increase HL risk, including HLA-B*05 [104,105], HLA-B*08 [104][105][106]111] and HLA-B*37 [108,109,112], while HLA-A*02 [79,103,108], HLA-A*03 [104] and HLA-A*11 [105] have been associated with decreased risk (Table S2). HLA-A*02 was associated with decreased EBV-positive HL risk, with no evidence of association t with EBVnegative HL [79,103].…”

Section: Hla Class Imentioning

confidence: 99%

See 2 more Smart Citations

The role of HLA variation in lymphoma aetiology and survival

et al. 2019

View full text Add to dashboard Cite

Epidemiologic and laboratory evidence has consistently supported a strong inflammatory and immune component for lymphoma aetiology. These studies have consistently implicated variation in the immune gene, human leucocyte antigen (HLA), to be associated with lymphoma risk. In this review, we summarize the historical and recent evidence of HLA in both lymphoma aetiology and survival. The recent momentum in uncovering HLA associations has been propelled by the conduct of genome‐wide association studies (GWAS), which has permitted the evaluation of imputed HLA alleles in much larger sample sizes than historically feasible with allelotyping studies. Based on the culmination of smaller HLA typing studies and larger GWAS, we now recognize several HLA associations with Hodgkin (HL) and non‐Hodgkin lymphomas (NHLs) and their subtypes. Although other genetic variants have also been implicated with lymphoma risk, it is notable that HLA associations have been reported in every NHL and HL subtype evaluated to date. Both HLA class I and class II alleles have been linked with NHL and HL risk. It is notable that the associations identified are largely specific to each lymphoma subtype. However, pleiotropic HLA associations have also been observed. For example, rs10484561, which is in linkage disequilibrium with HLA‐DRB1*01:01˜DQA1*01:01˜DQB1*05:01, has been implicated in increased FL and DLBCL risk. Opposing HLA associations across subtypes have also been reported, such as for HLA‐A*01:01 which is associated with increased risk of EBV‐positive cHL but decreased risk of EBV‐negative cHL and chronic lymphocytic leukaemia/small cell lymphoma. Due to extensive linkage disequilibrium and allele/haplotypic variation across race/ethnicities, identification of causal alleles/haplotypes remains challenging. Follow‐up functional studies are needed to identify the specific immunological pathways responsible in the multifactorial aetiology of HL and NHL. Correlative studies linking HLA alleles with known molecular subtypes and HLA expression in the tumours are also needed. Finally, additional association studies investigating HLA diversity and lymphoma survival are also required to replicate initial associations reported to date.

show abstract

Section: Hla Class Imentioning

confidence: 99%

Section: Hla Class Imentioning

confidence: 99%

Section: Hla Class Imentioning

confidence: 99%

See 1 more Smart Citation

The role of HLA variation in lymphoma aetiology and survival

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, with the exception of the nodular sclerotic type of HD, increased risk is consistently associated with A1 and A8. The " 4 C " group of antigens (B5, Bw35, Bw15, B18) is less clearly associated with HD (Falk and Osoba, 1971 ;Graff et al, 1974;McDevitt and Bodmer, 1974;Kissmeyer-Nielsen et al, 1975). In inbred mice, genes regulating susceptibility to virus leukemogenesis and immune response are closely linked to histocompatibility genes (Lilly and Pincus, 1973;Benacerraf and Dorf, 1974); thus the HLA association with HD may reflect enhanced susceptibility to an oncogenic virus (Forbes and Morris, 1972).…”

Section: Biologic Considerationsmentioning

confidence: 99%

Epidemiology of Hodgkin's disease in the young

Gutensohn

Cole

1977

Intl Journal of Cancer

186

View full text Add to dashboard Cite

Many features of Hodgkin's disease (HD) among adolescents and young adults suggest that it has an infectious etiology. However, the proposal that HD is a contagious disease which can be transmitted by patients or their close contacts has not been substantiated. An alternative infectious disease model is suggested by analogy with paralytic poliomyelitis (PP). For both diseases, the peak age of incidence is delayed as living conditions improve. For both, increased risk is associated with higher social class and small family size. Like PP, HD may be a rare manifestation of a common infection with the probability of disease development increasing as age at infection is delayed. This analogy is supported by the report that the risk of HD is higher for persons who had a low frequency of childhood infectious diseases. If this model is valid, HD patients represent no hazard to their contacts. However, the incidence of HD among young adults may increase in the coming decade because of the current high standard of living and small family size.

show abstract

“…However, this difference permits no conclusion concerning a possible aetiologic role of EBV. Kissmeyer-Nielsen et al (1975) found that the incidence of HL-A1 is increased in Danish patients acquiring HD. Since HL-A may represent a genetic marker for an immune-response gene (Morris, 1975) we have been looking for a correlation between HL-A1 and EB-VCA titre in the H D patients.…”

Section: Discussionmentioning

confidence: 97%

A case control study on immunity to two epstein‐barr virus‐associated antigens, and to herpes simplex virus and adenovirus in a population‐based group of patients with hodgkin's disease in denmark, 1971–73

Hesse

Ebbesen

Levine

et al. 1977

Intl Journal of Cancer

View full text Add to dashboard Cite

One hundred and eighty-five patients with untreated Hodgkin's disease (HD) comprising 86% of all new cases diagnosed in Denmark over a 2-year period, were individually matched with healthy controls of the same age, sex, and social class. In comparison to controls, HD patients showed significantly elevated mean antibody titres to Epstein-Barr viral capsid antierences in mean titres were found for adenovirus common antigen. Subdivision of the patients by age, sex, social class, HL-A antigens, stage of disease and histology did not alter this pattern, except that significant case-control differences in EB-VCA titres could be demonstrated only for the nodular sclerosis and lymphocyte predominance subgroups. After 1 year of treatment, a significant rise in EB-VCA mean titre had taken place. Splenectomy seemed to promote this titre elevation. Neither the initial titres to EB-VCA and EBV-EA nor changes in titres over time were related to prognosis. The results of our study, which are more representative of a population of HD patients and controls than previously reported studies, confirm that the reported relationship between EBV and HD exists, but that the elevated EBV titres are probably not of etiologic significance in most HD patients.

show abstract

HL‐A in Hodgkin's Disease. III. A Prospective Study

Cited by 6 publications

References 2 publications

The role of HLA variation in lymphoma aetiology and survival

The role of HLA variation in lymphoma aetiology and survival

Epidemiology of Hodgkin's disease in the young

A case control study on immunity to two epstein‐barr virus‐associated antigens, and to herpes simplex virus and adenovirus in a population‐based group of patients with hodgkin's disease in denmark, 1971–73

Contact Info

Product

Resources

About