HL-A Antigens in Hodgkin's Disease: Histopathologic and Clinical Correlations

Ks, Graff; Rm, Simon; Ra, Yankee; Vt, DeVita; Gn, Rogentine

doi:10.1093/jnci/52.4.1087

Cited by 14 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been rather disappointing that HLA antigens have not been clearly associated with any specific cancer (Terasaki et al, 1977). Positive associations have been reported for Hodgkin's disease (Graff et al, 1974), breast cancer (Pate1 et al, 1972 and nasopharyngeal cancer (Simmons et al, 1974), but other studies could not confirm the association (De Jong-Bakker et al, 1974;Betuel et al, 1975).…”

Section: Discussionmentioning

confidence: 96%

HLA antigens in stomach cancer

Nomura

Glober

Terasaki

et al. 1980

Intl Journal of Cancer

View full text Add to dashboard Cite

HLA antigens were identified for 99 Japanese patients with stomach cancer and for 222 controls in Hawaii. There were 68 patients with the intestinal/other histological type of stomach cancer and 31 patients with the diffuse type who may be genetically predisposed towards developing the disease. No significant differences in antigen frequency were noted between cases of the diffuse or intestinal/other histological type and the controls, or between the diffuse and intestinal/other type stomach cancer cases.

show abstract

Section: Discussionmentioning

confidence: 96%

HLA antigens in stomach cancer

Nomura

Glober

Terasaki

et al. 1980

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…However, with the exception of the nodular sclerotic type of HD, increased risk is consistently associated with A1 and A8. The " 4 C " group of antigens (B5, Bw35, Bw15, B18) is less clearly associated with HD (Falk and Osoba, 1971 ;Graff et al, 1974;McDevitt and Bodmer, 1974;Kissmeyer-Nielsen et al, 1975). In inbred mice, genes regulating susceptibility to virus leukemogenesis and immune response are closely linked to histocompatibility genes (Lilly and Pincus, 1973;Benacerraf and Dorf, 1974); thus the HLA association with HD may reflect enhanced susceptibility to an oncogenic virus (Forbes and Morris, 1972).…”

Section: Biologic Considerationsmentioning

confidence: 99%

Epidemiology of Hodgkin's disease in the young

Gutensohn

Cole

1977

Intl Journal of Cancer

186

View full text Add to dashboard Cite

Many features of Hodgkin's disease (HD) among adolescents and young adults suggest that it has an infectious etiology. However, the proposal that HD is a contagious disease which can be transmitted by patients or their close contacts has not been substantiated. An alternative infectious disease model is suggested by analogy with paralytic poliomyelitis (PP). For both diseases, the peak age of incidence is delayed as living conditions improve. For both, increased risk is associated with higher social class and small family size. Like PP, HD may be a rare manifestation of a common infection with the probability of disease development increasing as age at infection is delayed. This analogy is supported by the report that the risk of HD is higher for persons who had a low frequency of childhood infectious diseases. If this model is valid, HD patients represent no hazard to their contacts. However, the incidence of HD among young adults may increase in the coming decade because of the current high standard of living and small family size.

show abstract

“…Finally, we wish to mention the possibility that some associations between HL-A antigens and diseases may have trivial explanations. For example, as suggested by Rogentine et al (1974), the possible increase of HL-A2 in long-term surviving patients with leukaemia may be due to the fact that HL-A2-positive individuals cannot form anti-HL-A2, which is otherwise a very common antibody, and as about ha^lf of all blood donors are HL-A2 positive, HL-A2-negative patients are less likely to benefit from random platelet transfusions than are HL-A2 positives. Accordingly, HL-A2 negatives have a higher risk of dying from haemorrhage when treated with cytostatica during relapse.…”

Section: B) Other Explanationsmentioning

confidence: 99%