HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin
Li Fan,
Cheng Tian,
Wentao Yang
et al.
Abstract:Background and AimsHexokinases (HKs), a group of enzymes catalyzing the first step of glycolysis, have been shown to play important roles in liver metabolism and tumorigenesis. Our recent studies identified HKDC1 as a top candidate associated with liver cancer metastasis. We aimed to compare its cell-type specificity with other HKs upregulated in liver cancer and investigate the molecular mechanisms underlying its involvement in liver cancer metastasis.Approach and ResultsWe found that, compared to HK1 and HK2… Show more
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