HIV treatment cascade in migrants and mobile populations

Tanser, Frank; Bärnighausen, Till; Vandormael, Alain; Dobra, Adrian

doi:10.1097/coh.0000000000000192

Cited by 97 publications

(104 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For these reasons, large-scale surveillance programs are typically undertaken on a periodic basis of 12 or more months, making it difficult to ascertain the precise date of an HIV infection. Factors associated with illness, work commitments, temporary or cyclical migration, assumed knowledge of current HIV status, and the stigma associated with a positive status, among others, may decrease the frequency at which an eligible individual is captured for HIV testing [18–20]. On the other hand, the identification of new HIV infections is possible for experimental trials where relatively small cohorts (typically <500 individuals) are routinely tested on a weekly or monthly basis [21–23].…”

Section: 0 Backgroundmentioning

confidence: 99%

Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundCross-sectional, biomarker methods to determine HIV infection recency present a promising and cost-effective alternative to the repeated testing of uninfected individuals. We evaluate a viral-based assay that uses a measure of pairwise distances (PwD) to identify HIV infection recency, and compare its performance with two serologic incidence assays, BED and LAg. In addition, we assess whether combination BED plus PwD or LAg plus PwD screening can improve predictive accuracy by reducing the likelihood of a false-recent result.MethodsThe data comes from 854 time-points and 42 participants enrolled in a primary HIV-1C infection study in Botswana. Time points after treatment initiation or with evidence of multiplicity of infection were excluded from the final analysis. PwD was calculated from quasispecies generated using single genome amplification and sequencing. We evaluated the ability of PwD to correctly classify HIV infection recency within <130, <180 and <360 days post-seroconversion using Receiver Operator Characteristics (ROC) methods. Following a secondary PwD screening, we quantified the reduction in the relative false-recency rate (rFRR) of the BED and LAg assays while maintaining a sensitivity of either 75, 80, 85 or 90%.ResultsThe final analytic sample consisted of 758 time-points from 40 participants. The PwD assay was more accurate in classifying infection recency for the 130 and 180-day cut-offs when compared with the recommended LAg and BED thresholds. A higher AUC statistic confirmed the superior predictive performance of the PwD assay for the three cut-offs. When used for combination screening, the PwD assay reduced the rFRR of the LAg assay by 52% and the BED assay by 57.8% while maintaining a 90% sensitivity for the 130 and 180-day cut-offs respectively.ConclusionPwD can accurately determine HIV infection recency. A secondary PwD screening reduces misclassification and increases the accuracy of serologic-based assays.

show abstract

Section: 0 Backgroundmentioning

confidence: 99%

Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the lack of access to healthcare and the low retention in the HIV treatment cascade among both the migrant population and sex tourists is extremely concerning. [28] Some limitations of our study should be noted. First, our participants were recruited for an online survey, and MSM recruited through the Internet in China are on average younger and better educated.…”

Section: Discussionmentioning

confidence: 99%

Sex tourism among Chinese men who have sex with men: a cross-sectional observational study

Mao

Tang²,

Liu³

et al. 2016

The Lancet

View full text Add to dashboard Cite

Background: Sex tourism among men who have sex with men (MSM) may exacerbate transmission of HIV and other sexually transmitted infections (STIs). Sex tourism is defined as purchasing sex with gifts or money outside of one's hometown. Our objective was to characterize the frequency, socio-demographic characteristics, and sexual risk behaviors among Chinese MSM sex tourists. Methods: An online, cross-sectional survey for high-risk MSM throughout China was conducted in November 2015 covering sociodemographic characteristics, sexual risk behaviors, and sex tourism. Univariate and multivariable logistic regressions were performed to identify correlates of sex tourism. The mean MSM HIV prevalence of sex tourism journey origins and destinations were compared. Results: Of 1189 MSM who completed the survey, 62 (5%) men identified as sex tourists; among these sex tourists, twenty (32%) traveled primarily to purchase sex and the remainder purchased sex while traveling for another purpose. There was minimal socio-demographic and behavioral difference between the two groups. In multivariable analyses, adjusting for age and income, sex tourism was correlated with high-risk sexual behaviors, higher income (aOR 4.44, 95%CI 1.77-11.18) and living with HIV (aOR 2.79, 95%CI 1.03-7.55). Sex tourism was more often from locations with lower to higher MSM HIV prevalence (mean = 4.47, SD = 2.01 versus mean = 6.86, SD = 5.24). Conclusion: MSM sex tourists were more likely to have risky sexual behaviors and travel to locations with a higher HIV prevalence. MSM sex tourists may be part of core groups that are disproportionately responsible for MSM HIV transmission. Enhanced surveillance and interventions tailored to MSM sex tourists should be considered.

show abstract

“…Twenty-two million people living with HIV are not accessing ART and later diagnosis remains a significant barrier to HIV treatment scale up (UNAIDS, 2016). Many individuals, particularly women, sex workers, men who have sex with men (MSM), transgender persons, those who engage in injection and non-injection drug use, migrants, and refugees continue to face discrimination, stigma, and lack of access to HIV information, testing, and treatment due to various policies and practices that uphold structural and social barriers (Arreola et al, 2015; Baral, Sifakis, Cleghorn, & Beyrer, 2007; Baral et al, 2012; Baral et al, 2013; Beyrer & Karim, 2013; Beyrer et al, 2014; Dellar, Dlamini, & Karim, 2015; El-Bassel, Shaw, Dasgupta, & Strathdee, 2014; Galeucia & Hirsch, 2016; Harrison, Colvin, Kuo, Swartz, & Lurie, 2015; Karim et al, 2010; Mayer, Grinsztejn, & El-Sadr, 2016; Tanser, Bärnighausen, Vandormael, & Dobra, 2015; Weine & Kashuba, 2012). …”

Section: ‘Seems Like Everybody Got It’: Hiv’s Enduring Legacy In the mentioning

confidence: 99%

Chronicity, crisis, and the ‘end of AIDS’

Sangaramoorthy

2018

Global Public Health

View full text Add to dashboard Cite

In biomedical, public health, and popular discourses, the ‘end of AIDS’ has emerged as a predominant way to understand the future of HIV research and prevention. This approach is predicated on structuring and responding to HIV in ways that underscores its presumed lifelong nature. In this article, I examine the phenomenon of HIV chronicity that undergirds the ‘end of AIDS’ discourse. In particular, I explore how the logic of HIV chronicity, induced by technological advances in treatment and global financial and political investments, intensifies long-term uncertainty and prolonged crisis. Focusing on over 10 years of anthropological and public health research in the United States, I argue that HIV chronicity, and subsequently, the ‘end of AIDS’ discourse, obscure the on-going HIV crisis in particular global communities, especially among marginalised and ageing populations who live in under-resourced areas. By tracing the ‘end of AIDS’ discourse in my field sites and in other global locations, I describe how HIV chronicity signals a continuing global crisis and persistent social precarity rather than a ‘break’ with a hopeless past or a promising future free from AIDS.

show abstract

HIV treatment cascade in migrants and mobile populations

Cited by 97 publications

References 66 publications

Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana

Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana

Sex tourism among Chinese men who have sex with men: a cross-sectional observational study

Chronicity, crisis, and the ‘end of AIDS’

Contact Info

Product

Resources

About