Objective
The Johns Hopkins Hospital Emergency Department (JHH-ED) has served as a window on the HIV epidemic for 25 years, and as a pioneer in ED-based screening/linkage-to-care (LTC) programs. We document changes in the burden of HIV and HIV care metrics to the evolving HIV epidemic in inner-city Baltimore.
Design/Methods
We analyzed seven serosurveys conducted on 18,144 adult JHH-ED patients between 1987–2013 as well as our HIV screening/LTC program (2007, 2013) for trends in HIV prevalence, cross-sectional annual incidence estimates, undiagnosed HIV, LTC, antiretrovirals (ARVs) treatment, and viral suppression.
Results
HIV prevalence in 1987 was 5.2%, peaked at >11% from 1992–2003 and declined to 5.6% in 2013. Seroprevalence was highest for black males (initial 8.0%, peak 20.0%, last 9.9%) and lowest for white females. Among HIV+ individuals, proportion of undiagnosed infection was 77% in 1987, 28% in 1992, and 12% by 2013 (p<0.001). Cross-sectional annual HIV incidence estimates declined from 2.28% in 2001 to 0.16% in 2013. Thirty-day LTC improved from 32% (2007) to 72% (2013). In 2013, 80% of HIV+ individuals had ARVs detected in sera, markedly increased from 2007 (27%) (p<0.001). Proportion of HIV+ individuals with viral suppression (<400 copies/ml) increased from 23% (2001) to 59% (2013) (p<0.001).
Conclusions
ED-based HIV testing has evolved from describing the local epidemic to a strategic interventional role, serving as a model for early HIV detection and LTC. Our contribution to community-based HIV-screening and LTC program parallels declines in undiagnosed HIV infection and incidence, and increases in ARV use with associated viral suppression in the community.