HIV Subtypes Distribution and Implication for Antiretroviral Treatment in a Ugandan Population

Baker, Chris A. R.; Bousheri, Stephanie; Ssewanyana, Isaac; Jones, Norman; K'Aluoch, Okumu; Baliruno, David; Ssali, Francis; Cao, Huyen

doi:10.1177/1545109707303938

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…HIV positive ART naive volunteers were randomly recruited from a prospective observational cohort study from individuals receiving care at the Mbarara Hospital Uganda AIDS Rural Treatment Outcomes (UARTO) in Mbarara, Uganda [10]. Demographic information, CD4+ T cell count, and HIV viral load were obtained at the time of enrollment, and then again at 3 and six months after initiation of ART.…”

Section: Methodsmentioning

confidence: 99%

Infection With Different HIV Subtypes Is Associated With CD4 Activation-Associated Dysfunction and Apoptosis

Bousheri¹,

Burke²,

Ssewanyana³

et al. 2009

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Determination of HIV-1 subtype may be important in the management of HIV infected individuals, particularly with regard to deciding the CD4 cell count at which to initiate ART. Non-B subtypes A and D are prevalent in Uganda and individuals infected with subtype D appear to have faster disease progression compared to those infected with subtype A. We examined the level of apoptosis in CD4+ T cells in a study cohort of volunteers infected with subtype A and D infection. Although the levels of apoptosis in the activated CD4+ cells significantly decreased with viral suppression, CD4+ apoptosis in individuals infected with subtype D were found to be significantly higher compared to those infected with subtype A prior to antiretroviral treatment. Surface expression of PD-1 on CD4 cells in subtype D was substantially higher compared to subtype A (p=0.03). This difference was not observed in the CD8 population (p>0.05). Our findings suggest that the infecting HIV subtypes exert an independent influence on the disease outcome in response to antiretroviral treatment.

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Section: Methodsmentioning

confidence: 99%

Infection With Different HIV Subtypes Is Associated With CD4 Activation-Associated Dysfunction and Apoptosis

Bousheri¹,

Burke²,

Ssewanyana³

et al. 2009

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Peripheral blood mononuclear cells (PBMCs) were separated and cryopreserved in liquid nitrogen until assay time as previously described. 13,14,[16][17][18] Approvals for these studies were obtained from the California Department of Public Health, the University of California, San Francisco, the Makerere University Research and Ethics Committee, the Ugandan National Council of Science and Technology, and the Joint Clinical Research Centre Institutional Board Review. All study participants gave written informed consent.…”

Section: Study Subjects and Samplesmentioning

confidence: 99%

The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda

Ssewanyana

Baker

Ruel

et al. 2009

AIDS Research and Human Retroviruses

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T cell activation is an important mechanism in HIV-associated immune depletion. We have previously demonstrated an association between the hyperactivation of CD4(+) and CD8(+) T cells and low CD4 status in HIV-infected Ugandan children. In this study, we explore differences in activation between naive and memory T cells in HIV-infected Ugandan children. A significant correlation between CD4- and CD8-mediated immune activation and CD4 status was observed only in the memory T cells. Antiretroviral (ART) untreated and treated HIV-positive and HIV-negative children displayed similar profiles of activation and distribution within the CD4(+) naive T cells. In contrast, significantly higher immune activation of the memory CD4(+) T cell subset was seen in ART-untreated children when compared to ART-treated or HIV-negative children. ART-mediated viral suppression led to the correction of CD4(+) immune activation to levels seen in uninfected children but did not increase the size of the memory CD4(+) T cell population. High levels of CD8(+) immune activation were also found in both naive and memory cell subsets. Antiretroviral treatment led to the normalization of CD8(+) T cell activation but did not correct the distribution of naive CD8(+) T cells. We also assessed PD-1 expression on CD8(+) T cells as a measure of immune dysfunction. Upregulation of PD-1 was highest in untreated children but persisted in ART-treated children compared to uninfected children. The mechanisms of immunopathogenesis in pediatric HIV infection likely involve distinct contributions from individual naive and memory T cells subsets.

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NAD+ treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells

Hong

Nie

et al. 2014

Neuroscience Letters

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HIV Subtypes Distribution and Implication for Antiretroviral Treatment in a Ugandan Population

Cited by 5 publications

References 25 publications

Infection With Different HIV Subtypes Is Associated With CD4 Activation-Associated Dysfunction and Apoptosis

Infection With Different HIV Subtypes Is Associated With CD4 Activation-Associated Dysfunction and Apoptosis

The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda

NAD+ treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells

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