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1989
DOI: 10.1056/nejm198912143212409
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HIV Revealed

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Cited by 66 publications
(10 citation statements)
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“…The early stages of human immunodeficiency virus (HIV) infection can be separated from the later progressively symptomatic stage by several years of clinical latency (1,2). Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3).…”
mentioning
confidence: 99%
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“…The early stages of human immunodeficiency virus (HIV) infection can be separated from the later progressively symptomatic stage by several years of clinical latency (1,2). Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3).…”
mentioning
confidence: 99%
“…Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3). The progression to acquired immunodeficiency syndrome (AIDS) is characterized by increased levels of viremia and p24 antigenemia, activation of HIV expression in infected cells, an increased number of infected cells, and severe immune dysfunction (1)(2)(3). These findings suggest that the evolution of HIV infection and the progression of immunosuppression is associated with an increased activation of latent virus.…”
mentioning
confidence: 99%
“…As tens of thousands ofpositive tests for antibody and hundreds of negative tests for free virus have shown (34), HIV remains typically dormant in "T-cell reservoirs" even during AIDS (82). The simultaneous occurrence of HIV viremia and antiviral antibodies was reported in some AIDS patients in 1989, but this observation has not been replicated by others (42,43). More and more of the AIDSassociated parasites are now named as AIDS cofactors of HIV, most recently HTLV and mycoplasma (45,88).…”
Section: Epidemiology Is Like a Bikini: What Is Revealed Is Interestimentioning
confidence: 99%
“…In response to this challenge it was agreed that the hypothesis cannot be defended in terms of orthodox virology, based on known genetic and biochemical properties of HIV (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). However, it was claimed that epidemiological evidence supports the Abbreviations: CDC, Centers for Disease Control; HIV, human immunodeficiency virus; HTLV, human T-cell leukemia virus.…”
Section: Epidemiology Is Like a Bikini: What Is Revealed Is Interestimentioning
confidence: 99%
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