“…The early stages of human immunodeficiency virus (HIV) infection can be separated from the later progressively symptomatic stage by several years of clinical latency (1,2). Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3).…”
mentioning
confidence: 99%
“…Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3). The progression to acquired immunodeficiency syndrome (AIDS) is characterized by increased levels of viremia and p24 antigenemia, activation of HIV expression in infected cells, an increased number of infected cells, and severe immune dysfunction (1)(2)(3). These findings suggest that the evolution of HIV infection and the progression of immunosuppression is associated with an increased activation of latent virus.…”
“…The early stages of human immunodeficiency virus (HIV) infection can be separated from the later progressively symptomatic stage by several years of clinical latency (1,2). Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3).…”
mentioning
confidence: 99%
“…Early infection is characterized by a low frequency of infected cells and a low level of viral expression (3). The progression to acquired immunodeficiency syndrome (AIDS) is characterized by increased levels of viremia and p24 antigenemia, activation of HIV expression in infected cells, an increased number of infected cells, and severe immune dysfunction (1)(2)(3). These findings suggest that the evolution of HIV infection and the progression of immunosuppression is associated with an increased activation of latent virus.…”
“…As tens of thousands ofpositive tests for antibody and hundreds of negative tests for free virus have shown (34), HIV remains typically dormant in "T-cell reservoirs" even during AIDS (82). The simultaneous occurrence of HIV viremia and antiviral antibodies was reported in some AIDS patients in 1989, but this observation has not been replicated by others (42,43). More and more of the AIDSassociated parasites are now named as AIDS cofactors of HIV, most recently HTLV and mycoplasma (45,88).…”
Section: Epidemiology Is Like a Bikini: What Is Revealed Is Interestimentioning
confidence: 99%
“…In response to this challenge it was agreed that the hypothesis cannot be defended in terms of orthodox virology, based on known genetic and biochemical properties of HIV (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). However, it was claimed that epidemiological evidence supports the Abbreviations: CDC, Centers for Disease Control; HIV, human immunodeficiency virus; HTLV, human T-cell leukemia virus.…”
Section: Epidemiology Is Like a Bikini: What Is Revealed Is Interestimentioning
confidence: 99%
“…For example, HTLV is endemic in certain islands of Japan and marks specific ethnic groups among mixed populations in the Caribbean (86). Wild animals (29,85,86) or humans (42,43,86) with an acute retrovirus infection are virtually never observed. Acute retrovirus infections result from experimental infection or horizontal infections among mass-bred animals, typically prior to immune competence with virus strains not covered by maternal antibodies (76,77,85).…”
Section: Epidemiology Is Like a Bikini: What Is Revealed Is Interestimentioning
The newly defined syndrome AIDS includes 25 unrelated parasitic, neoplastic, and noninfectious indicator diseases. Based on epidemiological correlations, the syndrome is thought to be due to a new, sexually or parenterally transmitted retrovirus termed human immunodeficiency virus (HIV). The following epidemiological data conflict with this hypothesis. (i) Noncorrelations exist between HIV and AIDS; for example, the AIDS risks of infected subjects vary greater than 10-fold with their gender or country. Abnormal health risks that are never controlled as independent AIDS causes by AIDS statistics, such as drug addiction and hemophilia, correlate directly with an abnormal incidence of AIDS diseases. Above all, the AIDS diseases occur in all risk groups in the absence of HIV. (ii) American AIDS is incompatible with infectious disease, because it is almost exclusively restricted to males (91%), because if it occurs, then only on average 10 years after transfusion of HIV, because specific AIDS diseases are not transmissible among different risk groups, and because unlike a new infectious disease, AIDS has not spread exponentially since the AIDS test was established and AIDS received its current definition in 1987. (iii) Epidemiological evidence indicates that HIV is a long-established, perinatally transmitted retrovirus. HIV acts as a marker for American AIDS risks, because it is rare and not transmissible by horizontal contacts other than frequent transfusions, intravenous drugs, and repeated or promiscuous sex. It is concluded that American AIDS is not infectious, and suggested that unidentified, mostly noninfectious pathogens cause AIDS.
CD8+CD57+ T cells, expanded in peripheral blood lymphocytes of AIDS patients, inhibit the effector phase of HLA-specific cytotoxic T lymphocytes, natural killer and lymphocyte-activated killer cells in a 4-h chromium-release assay. This inhibitory activity present in supernatants of purified sorted CD8+CD57+ cells is mediated by a non-antigen-specific inhibitory factor which is distinct from prostaglandin E2, T cell growth factor (TGF)-beta, latent-TGF-beta, tumor necrosis factor (TNF)-alpha and TNF-beta. Partial biochemical characterization demonstrates that the CD8+CD57+ inhibitory activity (a) is heat, trypsin and acid resistant, (b) binds to concanavalin A columns, indicating its glycosylation state and (c) is mediated by a 20-30-kDa soluble molecule.
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