HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: Results from a prospective observational study in Germany

Uhrmacher, M.; Skaletz‐Rorowski, Adriane; Nambiar, Sandeep; Schmidt, Axel J.; Ahaus, Patrick; Serova, Katja; Mordhorst, I.; Kayser, Arne; Wach, Janet; Tiemann, Carsten; Münstermann, D.; Brockmeyer, Norbert H.; Potthoff, Anja

doi:10.3389/fpubh.2022.930208

Cited by 6 publications

(8 citation statements)

References 22 publications

(33 reference statements)

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“…The higher level of retention observed in our center compared with previous studies did not appear to be explained by differences in participants’ characteristics. As in other studies, patients were generally younger than 40 (between 62% and 81% in comparison with 71% in our patients) and were almost all MSM with only male sexual partners [ 2 , 4 , 5 , 6 , 11 , 19 , 20 , 21 , 22 , 26 , 27 ]. Characteristics regarding country of birth and work status were also similar in the studies for which this information was available [ 22 , 26 , 27 ].…”

Section: Discussionsupporting

confidence: 80%

“…As in other studies, patients were generally younger than 40 (between 62% and 81% in comparison with 71% in our patients) and were almost all MSM with only male sexual partners [ 2 , 4 , 5 , 6 , 11 , 19 , 20 , 21 , 22 , 26 , 27 ]. Characteristics regarding country of birth and work status were also similar in the studies for which this information was available [ 22 , 26 , 27 ]. Patients in our study showed a high (67%) but not unusual level of STI history; rates reported elsewhere ranged from 31% to 76% [ 2 , 17 , 22 , 24 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Discussionsupporting

confidence: 80%

“…Studies also reported similar levels of STIs at initiation (21% vs. 17% to 26%) [ 12 , 21 , 24 , 27 ]. A history of PEP was also frequent although variable, at a rate of between 8% and 53% in comparison to 38% in our study [ 2 , 6 , 20 , 22 , 26 , 27 , 28 , 32 ]. Although direct and complete comparison is not possible, our population appeared to show a similar risk level for HIV infection as participants in previous studies.…”

Section: Discussioncontrasting

confidence: 73%

“…Characteristics regarding country of birth and work status were also similar in the studies for which this information was available [ 22 , 26 , 27 ]. Patients in our study showed a high (67%) but not unusual level of STI history; rates reported elsewhere ranged from 31% to 76% [ 2 , 17 , 22 , 24 , 26 , 27 , 28 , 29 , 30 , 31 ]. Studies also reported similar levels of STIs at initiation (21% vs. 17% to 26%) [ 12 , 21 , 24 , 27 ].…”

Section: Discussionmentioning

confidence: 88%

“…Besides France, other countries offer access to PrEP free of charge or at reduced costs on a national scale or in particular settings [ 35 ]. Yet studies on PrEP retention in these countries also showed lower rates [ 22 , 26 , 27 ]. The particular setting of our sexual health center may therefore also play a part in the effectiveness of our PrEP program.…”

Section: Discussionmentioning

confidence: 99%

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Is HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men Effective in a Real-World Setting? Experience with One-On-One Counseling and Support in a Sexual Health Center in Paris, 2018–2020

Thomas¹,

Piron

Rochebrochard

et al. 2022

IJERPH

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HIV pre-exposure prophylaxis (PrEP) is highly effective but depends on patients’ care engagement, which is often mediocre and poorly measured in real-world settings. This study aimed to assess the effectiveness of a PrEP program in a sexual health center that included accompanying measures to improve engagement. A retrospective observational study was conducted. All men who have sex with men (MSM) who initiated PrEP for the first time between 1 August 2018 and 30 June 2019 in the Fernand-Widal sexual health center, Paris, France, were included. Among the 125 MSM who initiated PrEP, the median age was 33 and most had only male partners. At initiation, 58% were considered at very high risk of HIV infection, mainly due to a history of post-exposure prophylaxis. During the first year, patients attended a median of three visits (Q1–Q3, 2–4). At 12 months, 96% (95% CI, 92.6 to 99.4) had a successful PrEP course, assessed by a novel metric. These results highlight the possibility of achieving a high PrEP success ratio among MSM in a real-world setting. The accompanying measures and one-on-one counseling by a trained counselor could explain the effectiveness of this PrEP program.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Is HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men Effective in a Real-World Setting? Experience with One-On-One Counseling and Support in a Sexual Health Center in Paris, 2018–2020

Thomas¹,

Piron

Rochebrochard

et al. 2022

IJERPH

View full text Add to dashboard Cite

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Sexuell übertragbare Infektionen unter dem Einfluss der COVID-19-Pandemie

2023

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Die Anzahl von sexuell übertragbaren Infektionen (STI) in Deutschland nimmt stetig zu. Im Rahmen der COVID-19-Pandemie kam es durch Umverteilung von Ressourcen des Gesundheitswesens zu Einschränkungen von Screening- und Testangeboten. In den Jahren der Pandemie wurden weniger STI gemeldet. Ein Teil hiervon lässt sich durch Einschränkungen von Sexualkontakten erklären und damit tatsächlich verminderten Infektionen, der weitaus größere Teil wird jedoch auf Unterdiagnostik und eine erhöhte Dunkelziffer zurückgeführt. In den nächsten Jahren wird ein starker Anstieg von Infektionen vorausgesagt. Die Wiederaufnahme von niedrigschwelligen Screeningangeboten ist wichtig, um Infektionen frühzeitig feststellen und therapieren zu können und die Weitergabe so einzudämmen.

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Coronavirus (COVID-19) and sexualised drug use among men who have sex with men: a systematic review

2023

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Drug-related harms, including harms from sexualised drug use (SDU), are disproportionately experienced by sexual and gender minority people, relative to their majority counterparts. Chemsex, a type of SDU practiced mainly by MSM, is associated with methamphetamine use and increased HIV seropositivity or risk of acquisition. Therefore, participants are at increased risk of immunocompromise. Existing evidence suggests that drug use increases following natural disasters. The impact of coronavirus disease 2019 (COVID-19) on chemsex is unknown. A PRISMA-adherent systematic review was conducted to synthesise reports of changes in the prevalence, frequency, or characteristics of drug use (and factors associated with these changes) following the onset of the COVID-19 pandemic. This report presents findings related to SDU/chemsex among MSM. A comprehensive search across nine databases, supplemented with backward-forward citation searching and contact with key opinion leaders, was conducted. Two reviewers carried out title-abstract screening, full-text screening, and data extraction. Following a final, single database search, nine studies were included in the narrative synthesis. More than half the sample were studies investigating HIV pre-exposure prophylaxis use. Twenty percent of participants in most studies reported chemsex participation. In four, participants reported a net increase or maintenance of chemsex participation during the pandemic and five reported a net decrease. Increased chemsex participation was associated with loneliness, cravings, and working during the pandemic. Decreased chemsex practice was associated with COVID-19-related fear. This synthesis suggests that chemsex practice continued, and for some MSM increased, throughout COVID-19 pandemic ‘lockdowns’. This may have increased COVID-19 transmission and severity among potentially vulnerable MSM.

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HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: Results from a prospective observational study in Germany

Cited by 6 publications

References 22 publications

Is HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men Effective in a Real-World Setting? Experience with One-On-One Counseling and Support in a Sexual Health Center in Paris, 2018–2020

Is HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men Effective in a Real-World Setting? Experience with One-On-One Counseling and Support in a Sexual Health Center in Paris, 2018–2020

Sexuell übertragbare Infektionen unter dem Einfluss der COVID-19-Pandemie

Coronavirus (COVID-19) and sexualised drug use among men who have sex with men: a systematic review

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