HIV Postexposure Prophylaxis (PEP) in a Nigerian Tertiary Health Institution

Onyedum, Cajetan C; Chukwuka, Chinwe; Iyoke, Chukwuemeka Anthony; Omotola, Olusegun Funsho

doi:10.1177/1545109710397893

Cited by 9 publications

(39 citation statements)

References 7 publications

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“…The study revealed that more females enrolled into the PEP programme than males, with the majority being in the youth age bracket. This result was similar to the findings of another study (Onyedum et al, 2011). Since most of the cases with reported nature of exposure were due to occupational exposure, the young age may be due to the naivety of healthcare workers beginning their practices.…”

Section: Demographic Characteristics Of Pep Enrolleessupporting

confidence: 90%

“…There was no evidence to show that the other enrollees reported to the clinic for the follow-up such that the nonconduction of the tests cannot be solely blamed on the clinic. A study conducted in the same clinic vindicates the position as it showed that none of the enrollees returned to the clinic for follow-up counseling and test (Onyedum et al, 2011). This behaviour is however in contradiction to the result of a study in San Francisco in which 75% of those enrolled returned for HIV antibody test at the sixth month follow-up (Khan et al, 2001).…”

Section: Compliance Of Apin-cdc Clinic Unth Enugu Pep Practice Withmentioning

confidence: 91%

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Evaluation of HIV post-exposure prophylaxis (PEP) in a tertiary health institution in south-eastern Nigeria

Isah¹,

Uchenna²,

Adibe³

et al. 2016

J. AIDS HIV Res.

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This study aimed to evaluate the implementation of HIV post-exposure prophylaxis (PEP) guidelines and determine its clinical outcome in a PEPFAR (APIN-CDC) Clinic in south-eastern Nigeria from 2008 to 2012. It was a retrospective review of data of patients who accessed HIV PEP services from the clinic. Data on demographic and clinical characteristics of patients were retrieved from the database of the clinic and analyzed. Descriptive statistics and Chi-square test were applied to analyzed data at significance level of p<0.05. The result showed that thirty three (33) individuals were enrolled into PEP during the period. Thirty-one (31; 93.94%) were due to occupational exposure, while two (2; 6.06%) were due to non-occupational exposure. AZT+3TC 23 (69.70%), AZT+3TC+LPV/r 9 (27.27%) and AZT+3TC+ATV/r+RTV 1 (3.03%) were the ARVs used. The nature of exposure did not significantly determine the choice of the ARV. The study concludes that APIN/CDC Clinic, UNTH Enugu substantially followed recommendations of standard guidelines in HIV PEP management, but the absence of followup test results for majority of the enrollees was an impediment to any general statement on its clinical outcome.

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Section: Demographic Characteristics Of Pep Enrolleessupporting

confidence: 90%

Section: Compliance Of Apin-cdc Clinic Unth Enugu Pep Practice Withmentioning

confidence: 91%

Evaluation of HIV post-exposure prophylaxis (PEP) in a tertiary health institution in south-eastern Nigeria

Isah¹,

Uchenna²,

Adibe³

et al. 2016

J. AIDS HIV Res.

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“…The majority (207 out of 281) of HCWs in our study were doctors and students. Doctors and students are often involved in invasive medical procedures, which places them at risk of being exposed to infectious material [ 7 , 9 , 11 , 25 ]. Furthermore, students and doctors with less than a year’s experience, are prone to occupational exposure because of their inexperience [ 7 , 9 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study

et al. 2017

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BackgroundThere is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.MethodsA retrospective cohort study was conducted of HCWs attending a referral hospital’s Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available. Our primary outcome was LTFU at the 3-month visit. We selected seven variables a priori for our logistic regression model and ensured there were at least 10 outcome events per variable to minimize bias.ResultsTwo hundred and ninety-three folders were evaluated for descriptive analysis. LTFU worsened with successive visits: 36% at 6 weeks, 60% at 3 months, and 72% at 6 months. In multivariate analysis at the 3-month visit LTFU was associated with age (adjusted odds ratio (aOR), 0.6 per 10-year increase [95% CI, 0.5–0.9]), HCW category of doctor (aOR 2.7 [95% CI, 1.3–5.5]), and time from exposure to receiving PEP of more than 24 h (aOR 5.9 [95% CI, 1.3–26.9]).ConclusionWe identified factors associated with LTFU of HCWs after occupational HIV exposure, which could be used to target interventions to improve follow-up.

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“…Despite the level of awareness and knowledge demonstrated by the family physicians in our study, majority of those that had been exposed to NSI did not access HIV PEP, even though most of their institutions had existing HIV PEP policies and protocols. This knowledge–practice gap provides opportunities for targeted interventions to improve HCWs access to existing policies and protocols for effective utilization of HIV PEP which is needed to prevent seroconversions from NSI and other modes of occupational exposure, especially since recent reports from Nigeria indicate that this knowledge–practice gap is generalized among those at risk 92021. Special programs to improve knowledge and increase access to HIV PEP targeting senior doctors should also be encouraged and instituted.…”

Section: Discussionmentioning

confidence: 99%

Awareness and knowledge of human immunodeficiency virus post exposure prophylaxis among Nigerian Family Physicians

Agaba¹,

Agaba²,

Ocheke³

et al. 2012

Niger Med J

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Background:To determine the level of awareness and knowledge of HIV postexposure prophylaxis (HIV PEP) and determinants of adequate knowledge among Family Physicians in Nigeria.Materials and Methods:This was a cross-sectional questionnaire-based survey conducted among 175 Family Physicians at two national conferences.Results:Majority (97.7%) of the respondents was aware of the concept of HIV PEP and 99.4% believed it was effective in preventing HIV transmission. Over two third of our respondents had been exposed to NSI; however, less than 25% of those exposed received PEP. There was high level of knowledge of the various high-risk body fluids as well as types of high-risk exposures. 93.9% of our respondents knew that HIV PEP should commence within 1 h of exposure, 83.3% knew the correct duration of HIV PEP, but only 57.0% knew the ideal PEP regimen for high-risk exposures. The total mean score for our respondents was 17.8±2.9 with 79.4% having an adequate score. Being a junior doctor and male sex were associated with adequate knowledge.Conclusion:This study shows that despite high levels of awareness and knowledge of HIV PEP, access to its use among family physicians in Nigeria is still sub-optimal.

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HIV Postexposure Prophylaxis (PEP) in a Nigerian Tertiary Health Institution

Cited by 9 publications

References 7 publications

Evaluation of HIV post-exposure prophylaxis (PEP) in a tertiary health institution in south-eastern Nigeria

Evaluation of HIV post-exposure prophylaxis (PEP) in a tertiary health institution in south-eastern Nigeria

Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study

Awareness and knowledge of human immunodeficiency virus post exposure prophylaxis among Nigerian Family Physicians

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