HIV-positive patients with oral Kaposi's sarcoma: An overall survival analysis of 31 patients

Guedes, Pablyanne Tereza Louzada; Pontes, Flávia Sirotheau Corrêa; Prado‐Ribeiro, Ana Carolina; Rodrigues-Oliveira, Letícia; Brandão, Thaís Bianca; Souza, Lucas Lacerda de; Alves, Barbara Waleria Gonçalves; Lopes, Márcio Ajudarte; Santos‐Silva, Alan Roger; Monteiro, Julius Caesar Mendes Soares; Almeida, Oslei Paes de; Pontes, Hélder Antônio Rebelo

doi:10.1016/j.oooo.2020.11.007

Cited by 5 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kaposi sarcoma is a malignant vascular neoplasm induced by human herpesvirus type 8, which frequently occurs in cases of severe immunosuppression, such as AIDS. 16,17 Although in our case opportunistic infections common in cases of severe immunosuppression were ruled out, a recent study showed that the involvement of the gingival and hard palate by Kaposi sarcoma in people living with HIV was 9.7% and 35.5%, respectively. 17 Furthermore, nodules (33.5%) and tumors (48.4%) accompanied by bleeding (58%) stand out as the most frequently reported clinical presentations in individuals with Kaposi sarcoma.…”

Section: Discussionmentioning

confidence: 70%

Diagnosis and management of exuberant palatal pyogenic granuloma in a systemically compromised patient – Case report

Ventura,

Vogel,

Cortezzi

et al. 2023

Special Care in Dentistry

View full text Add to dashboard Cite

AimTo discuss the diagnosis and treatment of an exuberant oral pyogenic granuloma (OPG) in the palatal region in a systemically compromised patient.Methods and ResultsA 50‐year‐old woman presented with extensive and painless nodular mass that extended throughout the palatal region, with difficulty speaking, swallowing and spontaneous bleeding for 6 months. Her medical history showed poorly controlled type II diabetes mellitus and hypertension. The intraoral physical examination also revealed poor oral hygiene and periodontal disease. After clinical and radiographic evaluation, the presumptive diagnosis of OPG was made and complete excision of the lesion was performed. Local hemostatic measures were employed to control bleeding. Microscopic evaluation showed a lobulated lesion composed of many blood capillaries confirming the diagnostic hypothesis.ConclusionsIn summary, individuals with severe periodontal disease and systemic disorders may present exacerbated clinical presentations of OPG.

show abstract

Section: Discussionmentioning

confidence: 70%

Diagnosis and management of exuberant palatal pyogenic granuloma in a systemically compromised patient – Case report

Ventura,

Vogel,

Cortezzi

et al. 2023

Special Care in Dentistry

View full text Add to dashboard Cite

show abstract

“…Clinical and pathological information regarding oral KS is still very limited due to the diverse clinical presentation and because lesions are mostly presented in late manifestation of HIV/AIDS ( 4 , 11 , 19 ). The complete aetiopathogeneses of oral KS remains unclear, although HHV-8 represents the main etiological agent ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…When presented in the oral cavity, KS is most frequently diagnosed in the hard and soft palate ( 2 , 11 ). Oral tumours may present a wide diversity of presentations, varying from single spots to bleeding, painful and necrotic swellings ( 2 , 19 ). They also may present colour alteration in the buccal mucosa due to their angiogenic origin, ranging from red to purple lesions ( 5 , 7 , 8 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…The systemic affliction of HIV/AIDS patients generally causes, besides the oral cavity, development of KS in the skin, gastrointestinal and respiratory complex, consistent with the findings of the present study ( 22 ). Systemic conditions commonly associated with immunocompromised patients were also observed, including oral presentation of oral candidiasis and herpes simplex, as well as systemic diseases including tuberculosis, pneumonia, gastroenteritis, syphilis and meningitis ( 6 , 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…In cases that oral KS was not confirmed, when patients refused to participate the research and when laboratory tests were not assessed represented the exclusion criteria. Lesions were diagnosed following the methods of our study group ( 19 ). For better illustration, all cases were also stained with CD34, D2-40 (podoplanin) and Prox-1.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio

Rh¹,

Ll²,

Pt³

et al. 2021

Med Oral

View full text Add to dashboard Cite

Background Kaposi’s sarcoma (KS) is an uncommon, multifocal and angioproliferative lesion, which demonstrates a poor prognosis. The aim of the present research was to explore the association of HIV viral load, CD4+ and CD8+ counts and the CD4+/CD8+ ratio on the risk of oral Kaposi’s sarcoma (KS) development. Material and Methods A total of 62 patients were retrieved from March 2008 to October 2020 from the files of two oral pathology centres. Clinical, laboratory and follow-up data were retrieved from their medical files. Poisson regression was used to explore the role of history of immunosuppression and its association with oral KS development. A P-value <0.05 was considered significant. Results Sixty-two patients were included in the present study (32 with oral KS and 30 with no presentation of lesions anywhere on the body). Patients with oral KS presented a mean age of 32.6 years, and male patients were more affected. The hard palate (15 cases; 46.8%) was the main anatomical site affected. The lesions were mostly presented as swellings (13 cases; 40.6%) and nodules (12 cases; 37.5%). Systemic manifestations were also observed, including candidiasis (4 cases; 12.5%), bacterial infection (3 cases; 9.3%), tuberculosis (3 cases; 9.3%), herpes simplex (3 cases; 9.3%) and pneumonia (3 cases; 9.3%). A significant correlation was observed between HIV viral load, CD4+ count and the CD4+/CD8+ ratio with oral KS development. Conclusions HIV viral load, CD4+ count and the CD4+/CD8+ ratio are associated with oral KS development. Key words: Cancer, oral, Kaposi’s sarcoma, diagnostic.

show abstract

Management of Oral Lesions in HIV-Positive Patients

Motta¹,

Fonseca²,

Scarini³

et al. 2023

Clinical Decision-Making in Oral Medicine

View full text Add to dashboard Cite

HIV-positive patients with oral Kaposi's sarcoma: An overall survival analysis of 31 patients

Cited by 5 publications

References 33 publications

Diagnosis and management of exuberant palatal pyogenic granuloma in a systemically compromised patient – Case report

Diagnosis and management of exuberant palatal pyogenic granuloma in a systemically compromised patient – Case report

Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio

Management of Oral Lesions in HIV-Positive Patients

Contact Info

Product

Resources

About