HIV-positive patients undertaking ART have longer infertility histories than age-matched control subjects

Santulli, Piétro; Gayet, Vanessa; Fauque, Patricia; Chopin, Nicolás; Dulioust, Emmanuel; Wolf, Jean Philippe; Chapron, Charles; Ziegler, Dominique de

doi:10.1016/j.fertnstert.2010.09.018

Cited by 39 publications

(48 citation statements)

References 33 publications

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“…Mostly, they have focused on human papillomaviruses (HPV) [14,15,16,17,18], adenoviruses (AVs) [19], hepatitis B viruses (HBV) [20], human immunodeficiency viruses (HIV) [21] and JC polyomaviruses (JCV) [22]. Though there is no evidence to confirm that virus infections induce male infertility, impairment of sperm parameters has been reported in HPV [14,15,16] and in JCP [22].…”

Section: Discussionmentioning

confidence: 99%

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Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients

Chen

Kanno

et al. 2013

Journal of Reproduction and Development

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Recently we demonstrated an ectopic expression of the human herpesvirus 1 thymidine kinase (HHV1-TK) gene by functioning of an intrinsic endogenous promoter in the transgenic rat (TG-rat), suggesting that HHV1 infection in humans induces expression of the TK gene with the ectopic promoter in the testis and results in accumulation of HHV1-TK protein, triggering male infertility similar to that in the TG-rat. Hence, in this study, we started to investigate a relationship between infection of herpesvirus and human male infertility. Semen was donated by Chinese male infertile patients (153 men, aged 21–49 years) with informed consent, followed by DNA preparation and analysis by PCR and DNA sequencing. Semen volume, sperm number and density, and sperm motility were examined. DNAs of HHV1, HHV4, HHV5 and HHV6 were confirmed by PCR, electrophoresis and DNA sequencing. Finally, virus DNA was identified in 59 patients (39%). The number of carriers was 39 (25%) for HHV1, 6 (4%) for HHV4, 33 (22%) for HHV5 and 3 (2%) for HHV6, respectively. Moreover, double-infection was found in 22 out of 59 specimens (37%), most of which were double-infection of HHV1 and HHV5 (15 out of 22 carriers). Though slight severity was present in some of the carriers, the relationship between virus infection and sperm impairment was not conclusive. Accordingly, it is essential to examine whether the viral HHV1-TK gene is expressed in the testis of the infertile human HHV carrier.

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Section: Discussionmentioning

confidence: 99%

“…also reported abnormality in these parameters, presumably due to anti-retroviral treatment [24]. Meanwhile, Comar et al detected JCV DNA in 24.5% of semen samples and 43.4% of urine samples of male infertile patients [21]. Kapranos et al .…”

Section: Discussionmentioning

confidence: 99%

Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients

Chen

Kanno

et al. 2013

Journal of Reproduction and Development

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“…Women were allocated to two groups according to the study protocol: the ''exposed'' infertile women with endometriosis (endometriosis group) were matched to ''unexposed'' infertile women without any evidence of endometriosis (disease-free group). These last were the first disease-free patients seen for pre-ART consultation immediately after each endometriosis case (19). The exclusion criteria were cancelled IVF cycles, lost at follow up, or refusal to sign the consent form.…”

Section: Study Protocolmentioning

confidence: 99%

“…All patients were synchronized using a timely administration of an OCP containing 0.03 mg of ethinyl estradiol and 0.15 mg of levonorgestrel (31). Various COS protocols were used, with 150-450 IU/day of purified folliclestimulating hormone or human menopausal gonadotropin: [1] a gonadotropin-releasing hormone antagonist protocol, [2] a long agonist protocol, or [3] a short agonist protocol (19). The gonadotropin dose and type of COS protocol were determined according to individual patient's characteristics.…”

Section: Controlled Ovarian Stimulation Regimenmentioning

confidence: 99%

Endometriosis-related infertility: assisted reproductive technology has no adverse impact on pain or quality-of-life scores

Santulli

Bourdon²,

Pressé³

et al. 2016

Fertility and Sterility

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“…Recent investigations on the putative role of viral agents in infertility and reproduction defects/pathologies have been primarily focused on human papillomaviruses (HPV). [4] Herpes simplex viruses (HSVs), Adenoviruses (AVs), Hepatitis B virus (HBV) and HIV have also been investigated [5]–[8].…”

Section: Introductionmentioning

confidence: 99%

Association between the JC Polyomavirus Infection and Male Infertility

et al. 2012

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In recent years the incidence of male infertility has increased. Many risk factors have been taken into consideration, including viral infections. Investigations into viral agents and male infertility have mainly been focused on human papillomaviruses, while no reports have been published on polyomaviruses and male infertility. The aim of this study was to verify whether JC virus and BK virus are associated with male infertility. Matched semen and urine samples from 106 infertile males and 100 fertile males, as controls, were analyzed. Specific PCR analyses were carried out to detect and quantify large T (Tag) coding sequences of JCV and BKV. DNA sequencing, carried out in Tag JCV-positive samples, was addressed to viral protein 1 (VP1) coding sequences. The prevalence of JCV Tag sequences in semen and urine samples from infertile males was 34% (72/212), whereas the BKV prevalence was 0.94% (2/212). Specifically, JCV Tag sequences were detected in 24.5% (26/106) of semen and 43.4% (46/106) of urine samples from infertile men. In semen and urine samples from controls the prevalence was 11% and 28%, respectively. A statistically significant difference (p<0.05) in JCV prevalence was disclosed in semen and urine samples of cases vs. controls. A higher JC viral DNA load was detected in samples from infertile males than in controls. In samples from infertile males the JC virus type 2 strain, subtype 2b, was more prevalent than ubiquitous type 1. JCV type 2 strain infection has been found to be associated with male infertility. These data suggest that the JC virus should be taken into consideration as an infectious agent which is responsible for male infertility.

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HIV-positive patients undertaking ART have longer infertility histories than age-matched control subjects

Cited by 39 publications

References 33 publications

Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients

Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients

Endometriosis-related infertility: assisted reproductive technology has no adverse impact on pain or quality-of-life scores

Association between the JC Polyomavirus Infection and Male Infertility

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