HIV peripheral neuropathy

Gabbai, Alberto Alain; Castelo, Adauto; Oliveira, Acary Souza Bullé

doi:10.1016/b978-0-444-52902-2.00029-1

Cited by 48 publications

(46 citation statements)

References 140 publications

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“…In the early stages of HIV infection, symptomatic neuropathy is seen in as few as 0.5 % of patients, but this increases dramatically as patients develop the full syndrome (Fuller et al 1993 ;Barohn et al 1993 ;So et al 1988 ;Hall et al 1991 ). Lange ( 1994 ), Gabbati et al ( 2013 ), and Centner et al ( 2013 ) provide a comprehensive review of the neuromuscular manifestations associated with HIV infection.…”

Section: Hiv Infectionmentioning

confidence: 97%

Infectious Diseases Causing Neuropathy

Bilbao

Schmidt

2014

Biopsy Diagnosis of Peripheral Neuropathy

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Section: Hiv Infectionmentioning

confidence: 97%

Infectious Diseases Causing Neuropathy

Bilbao

Schmidt

2014

Biopsy Diagnosis of Peripheral Neuropathy

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“…[33][34][35][36] HIV neuropathic pain with a sizeable morbidity is difficult to manage. 4 The HSV vector-mediated gene transfer may provide a novel approach to treating neuropathic pain. 37 In this study, we hypothesized that gp120 upregulates TNFa in the DRG and the spinal dorsal horn, which in turn upregulates the CXCR4/SDF1 pathway.…”

Section: And Hao 7 )mentioning

confidence: 99%

“…2,3 It has been found that 57% of HIV-infected individuals have distal symmetrical SN and 38% have neuropathic pain. 4 Pain is one of the most common complaint of HIV-SN; patients often have tactile allodynia in a stocking and/or glove distribution. 5 HIV-related neuropathic pain is a debilitating chronic condition that is severe and unrelenting.…”

Section: Introductionmentioning

confidence: 99%

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

et al. 2014

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Human immunodeficiency virus (HIV)-related neuropathic pain is a debilitating chronic condition that is severe and unrelenting. Despite extensive research, the detailed neuropathological mechanisms remain unknown, which hinders our ability to develop effective treatments. In this study, we investigated the role of proinflammatory molecules, tumor necrosis factor-α (TNFα), CXCR4 and stromal-derived factor-1 α (SDF1α), in the L4/5 dorsal root ganglia (DRG) and the spinal dorsal horn in HIV gp120 protein-mediated neuropathic pain. Our results showed that the application of HIV gp120 to the sciatic nerve induced upregulation of TNFα, CXCR4 and SDF1α in both the DRG and the lumbar spinal dorsal horn. Non-replicating herpes simplex virus (HSV) vector encoding the p55TNFSR gene and producing a TNF-soluble receptor (TNFSR) to block bioactivity of TNFα reversed mechanical allodynia. Intrathecal AMD3100 (CXCR4 antagonist) increased mechanical threshold. The HSV vectors expressing p55TNFSR reversed upregulation of TNFα, CXCR4 and SDF1α induced by gp120 in the DRG and the spinal dorsal horn. These studies suggest that proinflammatory TNFα to the CXCR4/SDF1 pathway has an important role in the HIV-related neuropathic pain state and that blocking the proinflammatory cytokines or chemokines is able to reduce neuropathic pain. This work provides a novel gene therapy proof-of-concept for HIV-associated neuropathic pain.

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“…47,50 HIV-ASSOCIATED NEUROPATHY Peripheral neuropathies are the most common neurological complication in HIV/ AIDS. 58 Cardiovascular involvement including autonomic dysfunction is well described in HIV infection. 12,59 As CAN may increase risk of sudden death, it becomes one of the important complications in HIV-infected patients.…”

Section: Gbs Introductionmentioning

confidence: 99%

“…CAN is more frequently seen in HIV-infected patients with lower CD4+ T-lymphocyte counts. 11,[58][59][60] In patients with CAN, medications and anesthetic agents that may increase risk of arrhythmia should be selected and used very cautiously. Several medications commonly used in treatment of HIV can be neurotoxic and may cause some of the abnormalities in autonomic testing.…”

Section: Gbs Introductionmentioning

confidence: 99%

Cardiac Involvement in Peripheral Neuropathies

Burakgazi

Almahameed

2016

Journal of Clinical Neuromuscular Disease

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Cardiac autonomic neuropathy (CAN) is the least recognized and understood complication of peripheral neuropathy. However, because of its potential adverse effects including sudden death, CAN is one of the most important forms of autonomic neuropathies. CAN presents with different clinical manifestations including postural hypotension, exercise intolerance, fluctuation of blood pressure and heart rate, arrhythmia, and increased risk of myocardial infarction. In this article, the prevalence, clinical presentations, and management of cardiac involvement in certain peripheral neuropathies, including diabetic neuropathy, Guillain-Barré syndrome, chronic inflammatory polyneuropathy, human immunodeficiency virus-associated neuropathy, hereditary neuropathies, and amyloid neuropathy are examined in detail.

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HIV peripheral neuropathy

Cited by 48 publications

References 140 publications

Infectious Diseases Causing Neuropathy

Infectious Diseases Causing Neuropathy

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

Cardiac Involvement in Peripheral Neuropathies

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