HIV-Negative Partnered Men's Willingness to Use Non-Occupational Post-Exposure Prophylaxis and Associated Factors in a U.S. Sample of HIV-Negative and HIV-Discordant Male Couples

Mitchell, Jason W.; Sophus, Amber I.; Petroll, Andrew E.

doi:10.1089/lgbt.2015.0065

Cited by 15 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…nPEP awareness was documented in 60.2% of participants, a similar rate to the 64% reported in MSM surveyed in three eastern Australian states ( n =16,022) [18] . However, a study of 176 US HIV-negative MSM in 2011 showed that only 28% of them had heard of it, which was much lower than in the present study [15] . In contrast, a very high proportion (82.3%) of Italian MSM ( n =1874) in 2014 had knowledge about nPEP [19] .…”

Section: Discussioncontrasting

confidence: 92%

“…Similarly, Mitchell et al . assessed the willingness and associated factors to take nPEP among 275 HIV-negative MSM and 58 HIV-discordant male couples in the USA and showed that 73% were extremely likely to use it if they had had unprotected sex with an HIV-positive individual [15] . Previous experience with nPEP in our study was 7%, which is higher than among MSM in the USA (3.2%) in 2013 [16] and Canada (3%) in 2016 [17] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Factors associated with intention to take non-occupational HIV post-exposure prophylaxis among Thai men who have sex with men

Chomchey

Woratanarat

Hiransuthikul

et al. 2017

Journal of Virus Eradication

View full text Add to dashboard Cite

Background Men who have sex with men (MSM) are disproportionately infected with HIV in Thailand. Factors affecting their intention to take non-occupational HIV post-exposure prophylaxis (nPEP) are not well understood. This study sought to determine factors associated with an intention to take nPEP in this population. Method This is a two-phase mixed-method study. Phase I was a cross-sectional survey of intention to take nPEP in 450 MSM attending for HIV testing, using a self-administered questionnaire. Phase II was a prospective descriptive study, using an in-depth interview among 40 MSM who had been exposed to HIV in the past 72 hours. Multiple logistic regression was used to evaluate factors relating to the intention to use nPEP. Results Among 450 MSM seeking HIV testing in Bangkok, 7% had ever taken nPEP. Only 40% expressed an intention to take it to prevent HIV acquisition, despite the fact that they were at high risk as evidenced by an 18.9% prevalence of HIV-positive status. Factors associated with an intention to take nPEP were awareness about nPEP, HIV knowledge, mode of sexual intercourse and circumcision. Among 40 MSM who were eligible for and offered nPEP, 39 agreed to take it, and all but one completed the 4-week course. Condom use increased and all 32 individuals who could be contacted tested HIV negative after nPEP. Conclusion A high HIV prevalence was found in MSM testing for HIV in this study. However, fewer than half of the participants expressed the intention to take nPEP if they were at risk for HIV infection. Efforts to create nPEP awareness and improve HIV knowledge in MSM are crucial to the successful implementation of nPEP as part of a combination package for HIV prevention in this high-risk population.

show abstract

Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Factors associated with intention to take non-occupational HIV post-exposure prophylaxis among Thai men who have sex with men

Chomchey

Woratanarat

Hiransuthikul

et al. 2017

Journal of Virus Eradication

View full text Add to dashboard Cite

show abstract

“…Despite potential benefits, the provision of nPEP remains underutilized because of the cost to patients. [ 48 ] In our study, 9 MSM gave up treatment since they could not afford the nPEP cost. Overall, half the participants selected the relatively inexpensive regimen of “TDF/FTC” ($ 286.96).…”

Section: Discussionmentioning

confidence: 90%

Implementation of HIV non-occupational post-exposure prophylaxis for men who have sex with men in 2 cities of Southwestern China

Zhu

Zhou

et al. 2021

Medicine

View full text Add to dashboard Cite

Non-occupational post-exposure prophylaxis (nPEP) has often relied on the joint work of emergency physicians and infectious disease specialists in busy emergency departments and human immunodeficiency virus (HIV)/sexually transmitted infections clinics abroad, where adherence education and follow-up are invariably reactive. In our pilot study, community-based organizations (CBOs) were invited to together implement the nPEP tailored to men who have sex with men (MSM) in 2 cities of Guangxi in Southwestern China, of which experiences and lessons drawn from would be provided to the promotion of nPEP in China.The study population enrolled MSM individuals prescribed nPEP from September 2017 to December 2019. One-to-one follow-ups by CBOs were applied through the treatment. Predictors of treatment completion were assessed by logistic regression.Of 271 individuals presented for nPEP, 266 MSM with documented treatment completion or non-completion, 93.6% completed the 28-day course of medication. Completion was associated with reporting side effects (aOR = .10; 95% CI: 0.02–0.38; P = .001). The follow-up rate of 91.9% was achieved based on the definition of loss to follow-up. No documented nPEP failures were found, although 1 MSM subsequently seroconverted to HIV due to ongoing high-risk behavior.CBOs’ engagement in HIV nPEP, especially the “one-to-one” follow-up supports by peer educators partly ensure adherence and retention to nPEP. Tailored interventions are needed to address the subsequent high-risk behaviors among the MSM population.

show abstract

“…Different from this study, a study in the United States revealed that men whose annual individual income less than $30,000 were more likely to use nPEP compared to those with high income. However, it was noteworthy that health insurance could often cover the costs of nPEP drug in US and their data also suggested that those with lower incomes might have difficulty in paying for nPEP without financial support [25]. It reminded us that we ought to take the income levels of drug users in different areas into account when drafting the price of nPEP.…”

Section: Resultsmentioning

confidence: 99%

Drug users’ perceptions, demands, and suggestions for non-occupational post-exposure prophylaxis (nPEP) services in China: a qualitative study

Jiao

Zhang³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Drug users are regarded as a high-risk population of HIV infection. Non-occupational post-exposure prophylaxis (nPEP) is internationally regarded as an effective biomedical prevention against HIV but still a small-scale pilot project in China at present. The aim of this study was to understand drug users’ perceptions demands and suggestions for nPEP service in China.Methods Nineteen eligible drug users were recruited in this qualitative study. Semi-structured in-depth interviews were conducted by trained interviewers. All of the interviews were audio-taped, transcribed verbatim and analyzed using thematic framework analysis.Results Most of participants had not heard of nPEP and none of them had used this service. After being informed basic knowledge of nPEP, about half of the participants reported willingness to use it. The facilitators included scare of HIV infection and regarding nPEP as a remedial measure in emergency. The barriers included low willingness for fatigue and lethargy after taking drugs, high price and side effects of nPEP medication, long course of nPEP treatment, and fear of privacy disclosure. Most of the participants thought the availability of nPEP would not increase the occurrence of unprotected intercourse and supported the routinization of nPEP services. Most participants chose social media for nPEP propaganda and pharmacies for providing nPEP.Conclusions It is imperative to strengthen propaganda and education of nPEP among drug users, and to encourage them to proactively use nPEP after exposure. Price regulation, side effect management and privacy protection need to be managed well when nPEP is routinized.

show abstract

HIV-Negative Partnered Men's Willingness to Use Non-Occupational Post-Exposure Prophylaxis and Associated Factors in a U.S. Sample of HIV-Negative and HIV-Discordant Male Couples

Abstract: Efforts should be made to increase male couples' awareness of nPEP and how to access nPEP. Uptake of nPEP has the potential to help avert new HIV infections among male couples.

Cited by 15 publications

References 36 publications

Factors associated with intention to take non-occupational HIV post-exposure prophylaxis among Thai men who have sex with men

Factors associated with intention to take non-occupational HIV post-exposure prophylaxis among Thai men who have sex with men

Implementation of HIV non-occupational post-exposure prophylaxis for men who have sex with men in 2 cities of Southwestern China

Drug users’ perceptions, demands, and suggestions for non-occupational post-exposure prophylaxis (nPEP) services in China: a qualitative study

Contact Info

Product

Resources

About