HIV Modifies the Effect of Tobacco Smoking on Oral Human Papillomavirus Infection

Alli, Babatunde Y.; Burk, Robert D.; Fatahzadeh, Mahnaz; Kazimiroff, Julie; Grossberg, Robert; Smith, Richard V.; Ow, Thomas J.; Wiltz, Mauricio; Polanco, Jacqueline; Rousseau, Marie; Nicolau, Bélinda

doi:10.1093/infdis/jiaa135

Cited by 7 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Active tobacco use has previously been shown to be associated with oral HPV infection among HIV + individuals, with positive associations seen with higher cumulative pack years and number of packs each day [ 5 , 20 , 36 ]. However, an association with history of tobacco smoking was not confirmed in the current study, where the odds of oral HPV were not significantly higher for current or former tobacco users compared to never users among either HIV + or HIV- individuals.…”

Section: Discussionmentioning

confidence: 99%

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Riddell

Brouwer

Walline

et al. 2022

Tumour Virus Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Riddell

Brouwer

Walline

et al. 2022

Tumour Virus Research

View full text Add to dashboard Cite

“…Studies have previously demonstrated a higher prevalence odds ratio of oral HPV persistence in never‐smoking PLWH than HIV‐negative never‐smokers 30 . Studies have shown that the elevated incidence of lung cancer remains elevated among PLWH compared with HIV‐negative individual despite careful adjustment for differences in smoking in the two popuations 31 .…”

Section: Discussionmentioning

confidence: 99%

Risk and incidence of head and neck cancers in veterans living with HIV and matched HIV‐negative veterans

Mazul

Hartman

Mowery

et al. 2022

Cancer

View full text Add to dashboard Cite

BACKGROUND:Persons living with HIV/AIDS have a higher incidence of virus-related and tobacco/alcohol-related cancers. This study is the first to estimate the effect of HIV versus HIV-negative veterans on the risk of head and neck squamous cell carcinoma incidence in a large retrospective cohort study. METHODS: The authors constructed a retrospective cohort study using patient data from 1999 to 2016 from the National Veterans Administration Corporate Data Warehouse and the VA Central Cancer Registry. This cohort study included 45,052 veterans living with HIV/AIDS and 162,486 HIV-negative patients matched by age, sex, and index visit (i.e., HIV diagnosis date or clinic visit date). The age-standardized incidence rates and estimated adjusted hazard ratios were calculated with a Cox proportional hazards regression for oropharyngeal and nonoropharyngeal head and neck cancer squamous cell carcinoma (HNSCC). The authors also abstracted human papillomavirus (HPV) status from oropharyngeal HNSCC diagnosed after 2010. RESULTS: Veterans living with HIV/AIDS (VLWH) have 1.71 (95% confidence interval [CI], 1.36, 2.14) times the risk of oropharyngeal cancer and 2.06 (95% CI, 1.76, 2.42) times the hazard of nonoropharyngeal cancer compared with HIV-negative veterans. VLWH with oropharyngeal squamous cell carcinoma (OPSCC) were more likely to be HPV-positive (N = 30 [81.1%]) than the HIV-negative veterans with OPSCC (N = 50 [67.6%]), although this difference was not significant (p = .135). For nonoropharyngeal cancer, the increased risk of oral cavity cancer among VLWH drove the increased risk. CONCLUSIONS:The study results suggest that HIV may play a role in virally mediated and nonvirally mediated HNSCC. As the HIV prevalence rises in the United States due to better survival and the incidence of HPV-positive oropharyngeal HNSCC increases, the interaction between HPV and HIV becomes increasingly relevant.

show abstract

“…HIV is a risk factor for smoking-associated cancers, especially in women 29. Cigarette smoke leads to immunosuppression and thus contributes to HPV acquisition in people living with HIV 30. Therefore, smoking is associated with a higher incidence and prevalence of high-risk HPV infection and HSIL in women living with HIV 31…”

Section: Discussionmentioning

confidence: 99%

Genotype-specific high-risk human papillomavirus infections and risk factors for cervical dysplasia in women with human immunodeficiency virus in Germany: results from a single-center cross-sectional study

Wagner

Skof

Sehouli

et al. 2022

Int J Gynecol Cancer

View full text Add to dashboard Cite

ObjectiveWomen living with HIV have an increased risk of human papillomavirus (HPV) infection and cervical cancer. Little is known about genotype-specific HPV prevalence, the impact of antiretroviral therapy, immunological status, and additional risk factors in women living with HIV in Germany. The goal of this study was to characterize the risk profile for cervical dysplasia in these women.MethodsPatients with HIV infection presenting at Charité-Universitätsmedizin Berlin from October 2017 to September 2020 were included and underwent gynecological examination, colposcopy, cervical cytology and HPV genotype testing. HPV genotypes were stratified by carcinogenicity. Atypical squamous cells of undetermined significance or higher were considered abnormal cytology. Data were analyzed by SPSS software (version 26, 2019). A two-tailed p-value ≤0.05 was considered statistically significant.ResultsA total of 84 women were evaluated. The majority (95.2%) received antiretroviral therapy. Median CD4 cell count was 564 cells/µl (range 20–1969). 95.2% were previously screened for cervical cancer. High-risk HPV prevalence was 44%. High-high-risk HPV subtypes (16, 18, 31, 33, 45, 52, 58) were significantly associated with abnormal cytology (p<0.001). HPV16 was the most common genotype (23%), was significantly associated with abnormal cytology (p=0.002) and was the main risk factor for abnormal cytology (OR 8.55, 95% CI 2.15 to 34.13, p=0.002), followed by age <35 years (OR 4.96, 95% CI 1.23 to 19.61, p=0.033) and cigarette smoking (OR 3.944, 95% CI 0.98 to 15.88, p=0.053).ConclusionsAntiretroviral therapy and adherence to cervical cancer screening was high. High-high-risk HPV, especially HPV16, coincided with high incidence of cytological abnormalities. Women living with HIV in Germany have adequate immune status and are often pre-screened for cervical cancer, and therefore have a different risk profile for cervical dysplasia than in low-income or medium-income countries. Adapted screening programs should be defined.

show abstract

HIV Modifies the Effect of Tobacco Smoking on Oral Human Papillomavirus Infection

Cited by 7 publications

References 31 publications

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Risk and incidence of head and neck cancers in veterans living with HIV and matched HIV‐negative veterans

Genotype-specific high-risk human papillomavirus infections and risk factors for cervical dysplasia in women with human immunodeficiency virus in Germany: results from a single-center cross-sectional study

Contact Info

Product

Resources

About