HIV-Malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, Kaduna State, Nigeria

Gumel, Shafi ́u Dahiru; Aliyu, Ibrahim; Olayinka, Adebola; Ibrahim, Muhammed Sani; Balogun, Muhammad Shakir; Dahiru, Afara; Ajayi, IkeOluwapo O.; Ajumobi, Olufemi; Ahmadu, Isiyaku; Song, Abubakar; Maifada, Asma’u Ibrahim; Abdullahi, Habibu

doi:10.37432/jieph.2021.4.1.31

Cited by 2 publications

(10 citation statements)

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“…In comparison with studies conducted in other region of the country, 17.8% from this study is higher than 14.2% and 14% reported among HIV patients in Uyo[ 33 ]; 16.2% in North Central Nigeria[ 34 ]; and lower than 22.9% malaria co-infection prevalence by Gumel et al . [ 35 ]; 24% in Jos[ 36 ]; 56.8% in Keffi[ 37 ]; 59.2% in Kaduna. [ 38 ] Other studies around the world showed as 14% among HIV seropositive patients in Cameroon[ 30 ]; 36% in South Africa[ 39 ] and 61.7% in Mozambique.…”

Section: Discussionmentioning

confidence: 99%

Occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria

Adeola

Kolawole

Yemi

et al. 2022

Journal of Family Medicine and Primary Care

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Introduction: Human immunodeficiency virus (HIV) and malaria infections are among the major public health concerns in sub-Saharan Africa, where they are associated with high morbidity and mortality. The study was conducted to assess the occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria. Methods: The study was cross-sectional, which involved 422 participants who were administered structured questionnaires for socio-demographic and clinical data. Venous blood was collected for malaria parasite detection and count from One hundred and seventy-four HIV seropositive individuals. They were re-examined clinically for HIV diagnosis, CD 4 + T cell counts, and packed cell volume (PCV). Results: The mean age of the participants was 28.48 ± 15.38 while the overall predominance of malaria among the HIV-positive patients was 11.5% (20/174). The malaria prevalence was significantly higher in female patients ( P = 0.0088) and occupational status among students ( P = 0.0001). Malaria/HIV co-infected patients had a significantly lower mean value of PCV ( P = 0.0001), CD 4 + cell count (0.0001), and temperature (0.0001) compared to HIV-infected patients having no malaria. Conclusion: The study showed that females had relatively higher malaria infection compared to their male counterparts. To achieve better management of HIV patients against malaria infection, proper preventive measures, antiretroviral therapy (ART), and chemoprophylaxis are a useful strategy to put in place. Also, the monitoring of CD 4 + cell count, viral load, and some hematology indices on a regular basis is crucial.

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Section: Discussionmentioning

confidence: 99%

Occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria

Adeola

Kolawole

Yemi

et al. 2022

Journal of Family Medicine and Primary Care

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“…Major public health issues in Nigeria include HIV and malaria (Avert, 2015; NMEP/ NPopC/NBS/ICF, 2016; Gumel et al, 2021). HIV infection impairs human immunity, making people more vulnerable to other illnesses like malaria (Douek et al, 2009;Aboud et al, 2010;WHO, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, Plasmodium, a single-celled microbe that infects red blood cells, is the cause of malaria, which has a higher propensity for severity and death in the presence of immunosuppression (Aboud et al, 2010). Also, it has been shown that HIV morbidity and death increase when malaria and HIV co-infection coexist (Uju et al, 2013;Gumel et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…HIV and malaria are two severe global public health issues (Gumel et al, 2021;Guerra et al, 2022). There is a significant geographic overlap between them globally, with the majority of those affected residing in sub-Saharan Africa, the Indian subcontinent, Southeast Asia, Latin America, and the Caribbean (Frischknecht & Fackler, 2016;Guerra et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…There is a significant geographic overlap between them globally, with the majority of those affected residing in sub-Saharan Africa, the Indian subcontinent, Southeast Asia, Latin America, and the Caribbean (Frischknecht & Fackler, 2016;Guerra et al, 2022). They result in more than two million yearly fatalities (Gumel et al, 2021). According to numerous studies (Korenromp et Recent hypotheses have proposed that there may be a high likelihood of HIV-malaria co-infection wherever the two diseases' geographic overlap occurs (Gumel et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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HIV/malaria co-infection and its determinants among people living with HIV/AIDS in Yenagoa, Bayelsa state, Nigeria

Iheanyi Omezuruike Okonko,

Nkem Shaibu,

Blessing Jachinma Okonko

et al. 2023

Magna Sci. Adv. Biol. Pharm.

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Major public health issues in Nigeria include HIV and malaria. HIV and malaria are two severe global public health issues. We conducted a cross-sectional study. One hundred and four HIV-infected individuals attending an antiretroviral treatment (ART) clinic in Yenagoa, Bayelsa State, were enrolled in this study using a random sampling technique. In order to gather data on the respondents' characteristics, questionnaires were given out. Venous blood samples were collected and analyzed for malaria parasite, CD4, and plasma viral load (PVL) using SD Boline RDT, Partec flow cytometer, and Abbott Real-Time protocol, respectively. All laboratory tests were performed following the manufacturer's instructions. The HIV/Malaria co-infection was 5.0%. A significant risk factor for the co-infection was high CD4 counts (p = 0.02). Age (p = 0.76), sex (p = 0.54), marital status (p = 0.47), education (p = 0.75), occupation (p = 0.57) and PVL (p = 0.39) were not significant (p > 0.05) risk factors. Though, a higher HIV/malaria co-infection occurred in the age group 21-40 years (6.0%), males (7.0%), CD4 counts >500 cells/µl (15.4%) and PVL <20 copies/ml (7.5%). In Yenagoa, Nigeria, the occurrence of HIV/malaria among PLWHA has been further established by the current study. Whereas their female counterparts showed a more significant propensity to HIV infection alone, males were more susceptible to HIV/Malaria co-infection. High CD4 levels were a significant risk factor for co-infection with HIV and malaria. HIV status did appear to affect a person's propensity to contract malaria, as HIV-positive individuals in Yenagoa, Nigeria, were shown to be more susceptible to the disease. We, therefore, urge that individuals living with HIV/AIDS be prioritized for any malaria intervention because of their vulnerability to malaria.

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HIV-Malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, Kaduna State, Nigeria

Cited by 2 publications

References 20 publications

Occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria

Occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria

HIV/malaria co-infection and its determinants among people living with HIV/AIDS in Yenagoa, Bayelsa state, Nigeria

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