HIV-Inhibitory and Cytotoxic Oligostilbenes from the Leaves of Hopea malibato

Abstract

Three new oligostilbenes, malibatols A (1) and B (2) and dibalanocarpol (3), together with one known oligostilbene balanocarpol (4), were isolated from the organic extract of the leaves of Hopea malibato. The structure elucidation of these compounds was based on the interpretation of their chemical and spectral data. Compounds 3 and 4 exhibited very modest HIV-inhibitory activity, while compounds 1 and 2 were cytotoxic to the host cells (CEM SS) in the antiviral assay.

A New Glycoside of Resveratrol Dimer from Stem Bark of Vitis vinifera

“…Thus, a bioassay-guided fractionation of the extract had performed and finally led to the isolation of a new glycoside of resveratrol dimer, (-)-ε-viniferin glycoside (1) and nine related resveratrol oligomers, i.e., ε-viniferin (2), 6 ampelopsin A (3), 7 isoampelopsin F (4), 8 caraphenol B (5), 8 malibatol A (6), 9 viniferaether B (7), 10 vitisin A (8), 6 cis-vitisin A (9), 11 vitisin B (10) 6 as active ingredients responsible for the antitumoral property. Structures of the isolated active components (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) were established by chemical and spectroscopic means.…”

“…Structures of the isolated active components (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) were established by chemical and spectroscopic means. In the present paper, we describe the identification of a new glycoside of resveratrol dimer (1), together with the cytotoxic effect of ten resveratrol oligomers (1-10) isolated from the stem bark extract of grapevine (Fig.…”

Modern Applied Science, Vol. 3, No. 4, April 2009, all in one file

“…These plants are mainly growth in tropical areas. The chemical research on these plants has long been done (Dai et al, 1998;Ito et al, 2000;Noviany et al, 2002;Saraswathy, et al, 1992;Sultanbawa et al, 1987;Zheng et al, 1994), but for such big family plants, the chemistry of Dipterocarpaceae is relatively less known. This is because the initial research on Dipterocarpaceae was mainly focused on chemical compounds of their resins such as terpenoid, sesquiterpen and triterpen.…”

Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors

“…In particular, benzofuran ring is a common moiety in many biologically active natural and therapeutic products [19][20][21] , some of which having substituents, and represent a very important heterocyclic pharmacophore 22 . Khellin 1 was one of several furochromones that can be isolated from fruits and seeds of Ammi visnaga L., a perennial herbaceous plant that grows wild in many Eastern Mediterranean countries which possesses a high active constituent of many modern medicines of antitumor properties [23][24][25][26][27][28][29][30][31][32][33][34] .…”