HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer

Silverberg, Michael J.; Leyden, Wendy A.; Warton, E. Margaret; Quesenberry, Charles P.; Engels, Eric A.; Asgari, Maryam M.

doi:10.1093/jnci/djs529

Cited by 186 publications

(143 citation statements)

References 52 publications

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“…In general, the presence of chronic immunosuppression has been linked to an increased risk for the development of squamous cell carcinomas (SCC) and to a lesser degree also basal cell carcinomas (BCC) (126)(127)(128)(129)(130). Most studies regarding NMSC in patients on immunosuppression have been reported in solid organ transplant patients.…”

Section: Epidemiology In Ibd Patientsmentioning

confidence: 99%

ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease

Farraye

Melmed

Lichtenstein

et al. 2017

American Journal of Gastroenterology

393

421

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Recent data suggest that infl ammatory bowel disease (IBD) patients do not receive preventive services at the same rate as general medical patients. Patients with IBD often consider their gastroenterologist to be the primary provider of care. To improve the care delivered to IBD patients, health maintenance issues need to be co-managed by both the gastroenterologist and primary care team. Gastroenterologists need to explicitly inform the primary care provider of the unique needs of the IBD patient, especially those on immunomodulators and biologics or being considered for such therapy. In particular, documentation of up to date vaccinations are crucial as IBD patients are often treated with long-term immune-suppressive therapies and may be at increased risk for infections, many of which are preventable with vaccinations. Health maintenance issues addressed in this guideline include identifi cation, safety and appropriate timing of vaccinations, screening for osteoporosis, cervical cancer, melanoma and non-melanoma skin cancer as well as identifi cation of depression and anxiety and smoking cessation. To accomplish these health maintenance goals, coordination between the primary care provider, gastroenterology team and other specialists is necessary. of evidence, we entered data from the papers of highest evidence into the GRADE program (accessible at http://www.gradepro.org ). Th e recommendation statements from this guideline are shown in Table 1 . Summary statements, when listed, are designed to be descriptive in nature without associated evidence-based ratings. VACCINATIONSRecent data suggest that IBD patients do not receive preventive services at the same rate as general medical patients ( 2 ). Members of the gastroenterology team are oft en the only clinicians that a patient with IBD will see. As such, it is incumbent upon gastroenterologists to take a proactive role in the health care needs of their IBD patients ( 3-5 ). It is crucial to clarify with the patient the limits of the specialist's responsibilities and delegate routine health care issues to the primary care clinician. It is equally important to educate the primary care clinician to the unique health maintenance needs of the IBD patient, especially those on immunomodulators and biologic agents. Although it appears that both primary care clinicians and gastroenterologists are hesitant to take ownership of vaccinations ( 6-8 ), it is reasonable ( 9 ) that vaccination recommendations be the responsibility of the treating gastroenterologist, but the actual delivery/administration of these vaccines may be a shared responsibility ( 10-13 ). Communicating specifi c recommendations to the primary care team in a concise fashion are needed. Consider empowering the patient by giving written recommendations to bring to their primary care physician. Clinicians sharing an electronic medical record should use this platform to send recommendations to the referring clinician.Patients with IBD are oft en treated with long-term immunesuppressive therapies and may t...

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Section: Epidemiology In Ibd Patientsmentioning

confidence: 99%

ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease

Farraye

Melmed

Lichtenstein

et al. 2017

American Journal of Gastroenterology

393

421

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“…Opportunistic infections are the most common manifestation, although sudden progression of existing KS or development of new lesions may also occur [73][74][75][76]. A systematic review identified 54 cohort studies of 13 103 patients starting HAART, of whom 1699 developed IRIS, 6.4% of whom had KS [77].…”

Section: Haartmentioning

confidence: 99%

“…With a follow-up of 28 months, a study presented only in abstract form reported an impressive CR rate and OS of 100% in patients treated with this regimen [74]. The studies performed in patients with BL are summarized in Table 4.7.…”

Section: Burkitt Lymphoma/leukaemiamentioning

confidence: 99%

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British HIV Association guidelines for HIV‐associated malignancies 2014

et al. 2014

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“…[9] Two studies indicate that HIV-positive white individuals have a higher incidence of SCC than HIV-negative individuals. [10,11] HIV is therefore likely to have an impact on the age dependence of SCC in SA, regardless of population group.…”

Section: Researchmentioning

confidence: 99%

The influence of HIV infection on the age dependence of squamous cell carcinoma of the skin in South Africa

et al. 2017

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Background. Cancer incidence typically increases with age, but it is not known whether ethnic characteristics influence the age dependence of squamous cell carcinoma of the skin (SCC). Objectives. (i) To determine the age dependence of SCC in the black African, coloured and white population groups of South Africa (SA); and (ii) to show whether any differences in the rate of change of age dependence could be influenced by diversity in behaviour and lifestyle, especially with regard to the prevalence of HIV infection, rather than by a fundamental variation in cancer biology between the populations. Methods. Linear regression analysis was applied to the logarithm of the age-specific incidence rates for SCC v. the logarithm of age between 35 and 74 years. The slopes of the regression (age exponent) were compared for each subset of gender, population group and year of diagnosis (between 2000 and 2010). Results. The most notable feature was the low value of the age exponent in both male and female black African compared with the white and coloured populations. This finding could be explained in part by the difference in the prevalence of HIV infection in the black African population group compared with the white and coloured population groups. Conclusions. The prevalence of HIV infection in black Africans in SA tends to decrease the apparent age component in SCC compared with the white and coloured population groups. Other factors relating to lifestyle and behaviour that differ between the population groups are also likely to influence the age component in SCC.

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HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer

Cited by 186 publications

References 52 publications

ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease

ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease

British HIV Association guidelines for HIV‐associated malignancies 2014

The influence of HIV infection on the age dependence of squamous cell carcinoma of the skin in South Africa

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