Hiv Infection of Human Cartilage

Campbell, Douglas L.; Li, P.; Oakeshott, R. D.

doi:10.1302/0301-620x.78b1.0780022

Cited by 17 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there were two reports of non-disinfected cartilage specimens from an infected donor that later showed HIV-1 in the tissues [8] and hepatitis C was reported to have been transmitted by non-disinfected bone, ligament and tendon [l 11.…”

Section: Discussionmentioning

confidence: 99%

Viruses adsorbed on musculoskeletal allografts are inactivated by terminal ethylene oxide disinfection

Moore

Gendler²,

Gendler

2004

Journal Orthopaedic Research

View full text Add to dashboard Cite

In 1987 it was anticipated that unsterilized tissues would transmit virus diseases such as hepatitis and HIV-1 from infected donors so a freeze-drying process for musculoskeletal tissue was developed to include terminal ethylene oxide (EO) exposure for 14 h. We found no studies of EO efficacy when viruses were associated with human allografts so we studied the antiviral effect of terminal EO disinfection using all but the final freeze-drying phase of this clinical processing protocol (CPP). Specifically we looked at EO inactivation of HIV-1, a human hepatitis B surrogate and test viruses known to be highly resistant to disinfecting agents, including irradiation. Freeze-drying, ordinarily required after EO disinfection and part of the CPP, was not done. Suspensions of HIV-1, Bovine viral diarrhea, Reovirus type 3, Duck hepatitis B, Poliomyelitis and Canine parvovirus were adsorbed on glass, demineralized bone powder, and preprocessed strips of femoral cortex, iliac wedges, cancellous blocks and patellar bone-tendon-bone preparations and subjected to EO disinfection. Test viruses were inactivated at the end of 7 h of EO disinfection, providing a safety factor in the CPP of at least 100%.Because allografts can transmit viruses, terminal EO disinfection should provide safer musculoskeletal allografts than nondisinfected tissues or those irradiated with a standard irradiation dose. New spontaneously appearing viruses would probably be inactivated with this terminal EO disinfection but they and viral bioweapons will require individual validation to assure viral inactivation.

show abstract

Section: Discussionmentioning

confidence: 99%

Viruses adsorbed on musculoskeletal allografts are inactivated by terminal ethylene oxide disinfection

Moore

Gendler²,

Gendler

2004

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…To date, little is known about whether HIV/ART can directly affect chondrocytes and the cartilage matrix. However, considering that HIV was reported to be able to infect chondrocytes [32], the more direct association between HIV/ART and cartilage matrix needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

Is treated HIV infection associated with knee cartilage degeneration and structural changes? A longitudinal study using data from the osteoarthritis initiative

Liu

Foreman

Joseph

et al. 2019

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Metabolic disorders presenting in HIV-infected patients on antiretroviral therapy (ART) may increase the risk of osteoarthritis. However, structural changes of the knee in HIV infected subjects are understudied. The aim of this study is to investigate knee cartilage degeneration and knee structural changes over 8 years in subjects with and without HIV infection determined based on the use of ART. Methods We studied 10 participants from the Osteoarthritis Initiative who received ART at baseline and 20 controls without ART, frequency matched for age, sex, race, baseline body mass index (BMI) and Kellgren & Lawrence grade. Knee abnormalities were assessed using the whole-organ magnetic resonance imaging score (WORMS) and cartilage T2 including laminar and texture analyses were analyzed using a multislice-multiecho spin-echo sequence. Signal abnormalities of the infrapatellar fat pad (IPFP) and suprapatellar fat pad (SPFP) were assessed separately using a semi-quantitative scoring system. Linear regression models were used in the cross-sectional analysis to compare the differences between ART/HIV subjects and controls in T2 (regular and laminar T2 values, texture parameters) and morphologic parameters (subscores of WORMS, scores for signal alterations of IPFP and SPFP). Mixed effects models were used in the longitudinal analysis to compare the rate of change in T2 and morphological parameters between groups over 8 years. Results At baseline, individuals on ART had significantly greater size of IPFP signal abnormalities ( P = 0.008), higher signal intensities of SPFP ( P = 0.015), higher effusion scores ( P = 0.009), and lower subchondral cysts sum scores ( P = 0.003) compared to the controls. No significant differences were found between the groups in T2-based cartilage parameters and WORMS scores for cartilage, meniscus, bone marrow edema patterns and ligaments ( P > 0.05). Longitudinally, the HIV cohort had significantly higher global knee T2 entropy values ( P = 0.047), more severe effusion ( P = 0.001) but less severe subchondral cysts ( P = 0.002) on average over 8 years. Conclusions Knees of individuals with HIV on ART had a more heterogeneous cartilage matrix, more severe synovitis and abnormalities of the IPFP and SPFP, which may increase the risk of incident knee osteoarthritis. Electronic supplementary material The online version of this article (10.1186/s12891-019-2573-5) contains supplementary material, which is available to authorized users.

show abstract

“…Thus, allograft bone seems to give good results [3]; however, banked allograft bone is not always available in many countries for spine surgery. Potential risks of bacterial contamination and viral transmission have also been suggested, although such a risk is very small [5,15,23].…”

Section: Discussionmentioning

confidence: 99%

Autogenous iliac crest bone graft versus banked allograft bone in scoliosis surgery in patients with Duchenne muscular dystrophy

Nakazawa

Takaso

Imura

et al. 2009

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

A total of 36 consecutive nonambulatory DMD patients underwent scoliosis surgery. Patients were divided into two groups: the autogenous iliac crest bone graft group (the ICBG group; 20 patients) and the allogenous bone graft group (the ALBG group; 16 patients). The mean preoperative curves measured 87°and 31°at the last follow-up in the ICBG group and 83°and 28°in the ALBG group. In the ICBG group, three (15%) patients had intraoperative sacroiliac joint penetration, five (25%) had iliac crest inner cortex penetration and three (15%) had postoperative prolonged wound drainage at the donor site. At three months after surgery, donor site pain caused by bone harvest was found in 50% with severe pain limiting their physical function and causing difficulties in sitting in a wheelchair in 40% of the patients, whereas patients in the ALBG group returned to their preoperative level of function soon after surgery.

show abstract

Hiv Infection of Human Cartilage

Cited by 17 publications

References 17 publications

Viruses adsorbed on musculoskeletal allografts are inactivated by terminal ethylene oxide disinfection

Viruses adsorbed on musculoskeletal allografts are inactivated by terminal ethylene oxide disinfection

Is treated HIV infection associated with knee cartilage degeneration and structural changes? A longitudinal study using data from the osteoarthritis initiative

Autogenous iliac crest bone graft versus banked allograft bone in scoliosis surgery in patients with Duchenne muscular dystrophy

Contact Info

Product

Resources

About