HIV infection, malaria, and pregnancy: a prospective cohort study in Kigali, Rwanda.

Ladner, Joël; Leroy, Valériane; Simonon, Arlette; Karita, Etienne; Bogaerts, J.; Clercq, A De; Perre, Philippe Van de; Dabis, François

doi:10.4269/ajtmh.2002.66.56

Cited by 49 publications

(37 citation statements)

References 29 publications

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“…This agrees with some data published in the literature 18 ; however, other studies performed in Sub-Saharan Africa have reported a significant association between maternal age and malaria during pregnancy 17,32 . Women who attended antenatal care during the second and third trimesters of pregnancy exhibited higher prevalences of malaria infection.…”

Section: Discussionsupporting

confidence: 93%

“…During the last decade, several studies were performed in African countries with high indices of transmission [17][18][19][20][21][22][23][24] ; however, few data were published for Angola, which is one of the five countries with the lowest available amounts of information regarding malaria during pregnancy, a fact that makes decisionmaking for prevention and control difficult 25 . The aim of this study was to assess the prevalence of P. falciparum and its possible associated risk factors in pregnant women who attended antenatal care in Luanda.…”

Section: Introductionmentioning

confidence: 99%

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Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Campos

Valente

Campos³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Malaria during pregnancy remains a serious public health problem. The aim of this study was to establish the prevalence and possible risk factors for malaria in pregnant women attending antenatal care at Augusto Ngangula Specialized General Hospital in Luanda, Angola. Methods: Pregnant women (679 total) who attended antenatal care from April to September 2008 were included in the study after signing informed consent. For each participant, the social-demographic profile and malaria and obstetric histories were investigated via a questionnaire. Diagnosis was made by optic microscopy, and hemoglobin concentration measured. The associations between age, parity, gestational age, residence, schooling, malaria during gravity, anemia and treatment with incidence of Plasmodium falciparum infection were analyzed through logistic regression. Results: During the period of study, 74 (10.9%) out of 679 women were infected by P. falciparum. The average concentration of hemoglobin was 11.1 ± 0.07g/dL, and there were significant associations between the history of malaria during pregnancy, P. falciparum infection (p<0.01) and anemia at the time of observation (p<0.001). Conclusions: Previous history of malaria during pregnancy represents a risk factor for current infection and anemia was an important complication associated with malaria, even in women who were treated with sulfadoxine-pyrimethamine during pregnancy.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Campos

Valente

Campos³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Our result showed that the prevalence of malaria was higher among the HIV-positive than the HIV-negative women in agreement with an earlier report. 10 However, the difference is not significant and since the numbers are very small, one less malaria infected HIV positive women would have removed any apparent difference between the groups. Furthermore, the mechanisms of the association between malaria and maternal HIV infection are potentially numerous and many aspects are still not fully understood.…”

mentioning

confidence: 95%

“…A number of reports have indicated a significant association between malaria during pregnancy and maternal age 7,8 while others did not. 9,10 The reason for these agerelated differences in malaria prevalence is probably © F e r r a t a S t o r t i F o u n d a t i o n related to host or environmental factors and requires further investigation. Primigravidae were significantly more likey to be infected with malaria than multigravidae.…”

mentioning

confidence: 99%

Assessment of malaria in pregnancy using rapid diagnostic tests and its association with HIV infection and hematologic parameters in South-Eastern Nigeria

Uneke¹,

Iyare²,

Oke³

et al. 2008

Haematologica

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Letters to the Editor haematologica | 2008; 93(1) | 143 | Assessment of malaria in pregnancy using rapid diagnostic tests and its association with HIV infection and hematologic parameters in South-Eastern Nigeria P. falciparum malaria in pregnancy was evaluated using histidine-rich proteins-2 RDT and related to HIV infection and hematologic parameters. Prevalence of malaria, HIV and anemia were 19.7%, 3.1% and 17.2% respectively. Primigravidae were significantly more infected with malaria. Malaria was not significantly associated with anemia, blood group, genotype and HIV infection. Haematologica. 2008 Jan; 93:(1) 143-144. DOI: 10.3324/haematol.11695 The enormous significance of malaria in pregnancy for public health makes early and accurate diagnosis of malaria absolutely imperative. Obtaining results quickly from the examination of blood samples from pregnant women with suspected malaria is now made possible by the use of rapid malaria diagnostic tests (RDTs). 1Although their use in developing countries has been limited by their high cost, RDTs have advantages over microscopy in their diagnostic precision and potential to help reduce drug costs due to over-prescription. In this study, we evaluated malaria in pregnancy using a P. falciparum RDT that detects histidine-rich proteins-2 (HRP-2) and its association with maternal HIV infection and hematologic parameters. This study was conducted in Abakaliki, south-eastern Nigeria, from June 2006 to December 2006 at the Ebonyi State University Teaching Hospital (EBSUTH). Approval was obtained from the Ethical Committee of the EBSUTH. Pregnant women at full term who were admitted at EBSUTH for childbirth and who fulfilled the following study inclusion criteria were enrolled: (i) attended the antenatal clinic at EBSUTH, (ii) had an uncomplicated singleton pregnancy ≥32 weeks' gestation (based on fundal height estimation), (iii) resident in Abakaliki or neighbouring local government areas, (iv) had no obvious clinical evidence of malaria (asymptomatic), and (v) had no known underlying chronic illness. After receiving informed consent, information about participants' age and parity were obtained from the case files of each individual and by interview. Shortly before child birth, about 5 mL of the maternal peripheral blood was obtained from each participant by venepuncture technique and placed in a sterile EDTA container for laboratory analysis.A rapid diagnostic test kit, the Smart Check Malaria P.f cassette (Globalemed, 1101 King St. Suite 370, Alexandria, VA 22314 USA) was used to assess malaria infection. The hemoglobin concentration (HbC) was determined using the cyanmethemoglobin method.2 The WHO definition of anemia in pregnancy, i.e., Hb<11g/dL, 3 was adopted. The hemoglobin genotype was determined by the Hemoglobin electrophoresis technique at alkaline pH using cellulose acetate membrane (CAM). 4 The ABO blood grouping test was performed using the slide method 2 with commercially available reagents (Murex Diagnostics, Inc. Dartford, UK). The HIV Tri Line Test ...

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“…Malaria has remained a serious public health concern in several countries of the world 1 , and is one of the oldest and most prevalent infectious diseases 2 . Estimates conservatively put the mortality from malaria between 1-2 million annually, majority of whom are children below the age of five and pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Lamivudine-Artesunate Co Administration Alters Piroxicam Mediated Analgesia in Mice

Olurishe

Kwanashie

Anuka

et al. 2011

Int Jour of Biomed Res

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SUMMARYLamivudine-Artesunate co-administration is common in HIV-malaria settings, as well as in prophylaxis for occupational HIV exposure and presumptive malaria treatment. Pain is a symptom often associated with malaria and HIV which is usually treated with piroxicam due to availability, affordability, and low addiction potential. This study evaluated possible analgesic effects of lamivudine and artesunate, and also the effect of lamivudine-artesunate co-administration on piroxicam mediated analgesia in mice using acetic acid induced writhing method. Animals received 21 day intraperitoneal treatments with vehicle, lamivudine, artesunate or lamivudine/artesunate co administration. The result showed that artesunate possessed analgesic properties, and that piroxicam mediated analgesia was significantly reduced (p<0.05) in the presence of concomitant lamivudine-artesunate treatment. This data suggests the need for caution and possible alternate analgesics while on lamivudine-artesunate therapy in order to effectively alleviate pain, when this is desired with lamivudine-artesunate co administration.

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HIV infection, malaria, and pregnancy: a prospective cohort study in Kigali, Rwanda.

Cited by 49 publications

References 29 publications

Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Assessment of malaria in pregnancy using rapid diagnostic tests and its association with HIV infection and hematologic parameters in South-Eastern Nigeria

Lamivudine-Artesunate Co Administration Alters Piroxicam Mediated Analgesia in Mice

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