“…There are studies that have looked into potential acceleration of liver toxicity with treatment of HIV with PIs in the face of hepatitis C coinfection (Benhamou et al, 2001;Kottilil, Polis, & Kovacs, 2004;Mehta et al, 2005;Sulkowski et al, 2000;Sulkowski, Berk & Dieterich, 2003;Sulkowski, Mehta, Chaisson, Thomas & Moore, 2004). Although these studies suggest caution and more frequent monitoring of LFTs, PI therapy has generally been found to be relatively safe and effective, with the possible exception of full-dose ritonavir-containing regimens in which the findings have been mixed (Antoniou & Tseng, 2002;Sulkowski et al, 2000Sulkowski et al, , 2003Sulkowski et al, , 2004.…”