HIV infection and electrocardiogram abnormalities: baseline assessment from the CHART cohort

Ding, Yingying; Zhu, Bowen; Lin, Hung-Ching; Chen, X.; Shen, Weiwei; Xu, Xiaohui; Shi, Richard; Zhao, Guochao; He, Na

doi:10.1016/j.cmi.2020.03.005

Cited by 11 publications

(13 citation statements)

References 29 publications

(32 reference statements)

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“…Longer HIV duration (≥5 years) was positively associated with ST interval (representing ventricular repolarisation) in the current study. Our findings support the results of a study by Ding et al [ 24 ], who showed that ST/T wave abnormalities were positively associated with HIV infection, ACR, Hb, fasting glucose and longer duration of HIV infection (≥3 years). ST/T wave abnormalities have been associated with the risk of developing ventricular tachycardia, myocardial ischaemia, myocardial infarction, and abnormal ventricular repolarisation [ 25 ].…”

Section: Discussionsupporting

confidence: 92%

“…ST/T wave abnormalities have been associated with the risk of developing ventricular tachycardia, myocardial ischaemia, myocardial infarction, and abnormal ventricular repolarisation [ 25 ]. This finding, however, contradicts Ding et al [ 24 ], who reported significant associations between blood pressure categories and ventricular abnormalities (ST/T abnormalities) in their HIV− group instead. Soliman et al [ 26 ], reported that ST/T abnormalities, in particular, may be predictive of CVD in PWH and highlighted the prognostic value of ST/T changes in HIV+ patients.…”

Section: Discussioncontrasting

confidence: 92%

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HIV and Antiretroviral Therapy Are Independently Associated with Cardiometabolic Variables and Cardiac Electrical Activity in Adults from the Western Cape Region of South Africa

Williams

Kamau

Everson

et al. 2021

JCM

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Cardiovascular-related complications are on the rise in people with HIV/AIDS (PWH); however, the relationship among HIV and antiretroviral therapy (ART)-related parameters, cardiovascular risk, and cardiac electrical activity in PWH remain poorly studied, especially in sub-Saharan African populations. We investigated whether HIV and ART are associated with cardiometabolic and cardiac electrical activity in PWH from Worcester in the Western Cape Province, South Africa. This was a cross-sectional study with HIV-negative (HIV−, n = 24) and HIV-positive on ART (HIV+/ART+, n = 63) participants. We obtained demographic, lifestyle, and medical history data and performed anthropometric, clinical assessments, and blood/urine biochemistry. We performed multiple stepwise linear regression analyses to determine independent associations among HIV, ART, cardiometabolic, and electrocardiographic (ECG) variables. HIV+/ART+ independently associated with a lower body mass index (p = 0.004), elevated gamma-glutamyl transferase levels (β: 0.333 (0.130–0.573); p = 0.002), and elevated alanine aminotransferase levels (β: 0.427 (0.224–0.629); p < 0.001) compared to HIV−. Use of second-line ART was positively associated with high-sensitivity C-reactive protein (p = 0.002). Although ECG parameters did not differ between HIV− and HIV+/ART+, viral load positively associated with p-wave duration (0.306 (0.018–0.594); p = 0.038), and longer HIV duration (≥5 years) with ST-interval (0.270 (0.003–0.537); p = 0.047) after adjusting for confounding factors. Our findings suggest that HIV and ART are associated with mixed effects on this population’s cardiometabolic profile and cardiac electrical activity, underpinning the importance of cardiovascular risk monitoring in PWH.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 92%

HIV and Antiretroviral Therapy Are Independently Associated with Cardiometabolic Variables and Cardiac Electrical Activity in Adults from the Western Cape Region of South Africa

Williams

Kamau

Everson

et al. 2021

JCM

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“…Those studied by His and Lamb were active Air Force personnel, while those in the current study were mainly civilians. In another study in China in adults [15], the prevalence of sinus bradycardia and sinus tachycardia in non-HIV positive subjects followed a similar pattern recorded in this study in which the prevalence of sinus bradycardia was higher than the prevalence of sinus tachycardia (prevalence of bradycardia, 9.4%; prevalence of tachycardia, 1.3%).…”

Section: Discussionsupporting

confidence: 85%

The Relationship Between Resting Heart Rate and Age in Adult Nigerians

Chime¹,

Okenwa²,

Oti³

2020

AJIM

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Background: Resting heart rate is related to cardiovascular mortality as well as to all-cause mortality. It is therefore important to know whether resting heart rate changes with age in adults. The aim of this study was to determine the relationship between heart rate and age in adult Nigerians. Methods: It was a retrospective study on adult Nigerians attending a University Teaching Hospital in Nigeria. All the needed data were retrieved from the medical records. Heart rate was calculated from the electrocardiogram and correlated with age. Results: There were 99 cases aged between 20 and 54 years and comprised of 60 males and 39 females. The mean heart rate was 73.40±13.16 beats/minute. Across the various decades, the mean heart rate in beats per minute was 73.46±10.70 in the third decade, 75.52±12.16 in the fourth decade, 72.38±13.91 in the fifth decade, and 71.60±18.77 in the sixth decade of life (p=0.770). Heart rate correlated negatively and weakly with age (r=-0.034, p=0.736). There were more cases of sinus bradycardia than sinus tachycardia, but the proportion of cases with heart rate outside 60 beats per minute to 100 beats per minute was small. Conclusion: This study showed that resting heart rate did not change with age in young adult and middle-aged Nigerians who had no clinical evidence of heart disease. A greater proportion of them were in normal sinus rhythm.

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“…Data for this analysis were derived from a cross‐sectional, baseline evaluation of PLWH and HIV‐negative individuals enrolling in an ongoing prospective cohort study of HIV and age‐related co‐morbidities (Comparative HIV and Aging Research in Taizhou, or CHART) in Taizhou prefecture of Zhejiang Province in eastern China [24,25]. From February 2017, we consecutively recruited PLWH (≥18 years) to CHART when they came to local Centres for Disease Control and Prevention to receive regular follow‐up medical care and assessments [23,28].…”

Section: Methodsmentioning

confidence: 99%

“…In 2016, China had eliminated the CD4 count thresholds on HIV treatment initiation, and treatment coverage for PLWH increased from 67% in 2015 to 83.4% in 2018 [23]. In our recent reports, subclinical atherosclerosis and electrocardiographic abnormalities were more prevalent among PLWH than among HIV‐negative individuals [24,25], emphasizing the urgent needs to address the cardiovascular risk among PLWH. The Chinese government has launched community‐based standardized BP management programmes over the past decade [26].…”

Section: Introductionmentioning

confidence: 99%

Differences in hypertension and prehypertension among people living with and without HIV in China: role of HIV infection and antiretroviral therapy

Lin²,

Chen³

et al. 2021

HIV Medicine

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Objectives Hypertension is a growing health concern in people living with HIV (PLWH). However, association between HIV infection and hypertension is equivocal. Methods In all, 1472 PLWH and 2944 HIV‐negative individuals frequency‐matched by age and sex were derived from the baseline survey of Comparative HIV and Aging Research in Taizhou (CHART), China. Prehypertension was defined as systolic blood pressure (BP) of 120–139 mmHg and/or diastolic blood pressure of 80–89 mmHg. Results Despite the fact that prevalence of hypertension was overall lower among PLWH than among HIV‐negative people (21.1% vs. 29.1%, P < 0.001), it was similar at ages 18–29 (7.6% vs. 8.5%) and 30–44 years (17.1% vs. 18.5%) but significantly lower in PLWH at ages 45–59 (26.1% vs. 40.7%) and 60–75 years (37.1% vs. 57.3%). Prehypertension prevalence was consistently higher in PLWH across all age groups. In the model adjusting for traditional risk factors, HIV infection was associated with hypertension (adjusted odds ratio [aOR] = 1.27, 95% confidence interval: 1.04–1.55) and prehypertension (aOR = 1.77, 95% CI: 1.51–2.08), and attenuated after additional adjustment for abdominal obesity. Age‐stratified analysis showed that these associations of HIV with hypertension were observed at ages 18–29 and 30–44 years and associations with prehypertension were observed at ages 18–29, 30–44 and 45–59 years only. Years since HIV diagnosis and stavudine use were the HIV‐specific factors independently associated with hypertension or/and prehypertension. Conclusions HIV infection is independently associated with prehypertension and hypertension especially at younger ages, and this risk may increase as treatment becomes prolonged. Our findings reinforce the urgent necessity for active BP screening and control strategies be adopted for PLWH in China.

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HIV infection and electrocardiogram abnormalities: baseline assessment from the CHART cohort

Cited by 11 publications

References 29 publications

HIV and Antiretroviral Therapy Are Independently Associated with Cardiometabolic Variables and Cardiac Electrical Activity in Adults from the Western Cape Region of South Africa

HIV and Antiretroviral Therapy Are Independently Associated with Cardiometabolic Variables and Cardiac Electrical Activity in Adults from the Western Cape Region of South Africa

The Relationship Between Resting Heart Rate and Age in Adult Nigerians

Differences in hypertension and prehypertension among people living with and without HIV in China: role of HIV infection and antiretroviral therapy

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