HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis: The role of monocyte chemoattractant protein-1

Coll, Blai; Parra, Sandra; Alonso-Villaverde, Carlos; Groot, Eric de; Aragonès, Gerard; Montero, Manuel; Tous, Mònica; Camps, Jordi; Joven, Jorge; Masana, Luís

doi:10.1016/j.cyto.2006.03.013

Cited by 46 publications

(31 citation statements)

References 20 publications

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“…Thus, the evidence from the trunk fat percentage is much higher in the group with lipodystrophy compared to the group without (Table 5), which reinforces the concern about harm that may arise from lipodystrophy [6][7][8] .…”

Section: Discussionsupporting

confidence: 60%

“…Besides creating a new aesthetic stigma 5 for this population, these changes in the distribution of adipose tissue may also increase the risk of developing cardiovascular diseases and diabetes [6][7][8] due to the excessive accumulation of abdominal fat. Thus, it is important to increase our understanding of the health consequences of central obesity, also called lipodystrophy, in HIV/AIDS patients.…”

Section: Introductionmentioning

confidence: 99%

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Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy

Segatto

Freitas

Santos

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction:Lipodystrophy is related to the use of highly active antiretroviral therapy (HAART) and can cause aesthetic stigma and increase the risk of developing cardiovascular diseases. Physical activity may be a valid alternative for the treatment and prevention of lipodystrophy. However, few studies address this issue. The objective of this study was to assess lipodystrophy related to highly active antiretroviral therapy in HIV/AIDS patients with different physical activity habits. Methods:The sample was composed of 42 HIV/AIDS patients taking HAART medication who were visiting the Counseling and Testing Center (CTC) in Presidente Prudente. The level of physical activity was obtained using the International Physical Activity Questionnaire (IPAQ); lipodystrophy was diagnosed using a self-report questionnaire that was administered to the patient and then followed up by medical confirmation. The percentage of trunk fat was estimated by dual X-Ray absorptiometry (DEXA). Information about sex, age, length of HAART treatment, CD4+ T lymphocyte count (CD4) and viral load was also collected. Results: A higher prevalence of lipodystrophy was observed in the sedentary group when compared to the physically active group, which indicates that physical activity may be a protective factor in relation to the occurrence of lipodystrophy. The group that had a higher CD4 had a higher proportion of lipodystrophy and a higher proportion of younger and physically active individuals. The patients with lipodystrophy had a higher percentage of trunk fat and were more sedentary than active individuals. Conclusions: A physically active lifestyle has a protective effect against the occurrence of lipodystrophy related to HAART.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy

Segatto

Freitas

Santos

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…In conclusion, considering the stronger relationship between CIMT and non-HDL-C, apoB, or TG/HDL ratio than with LDL-C, and the higher risk of cardiovascular events in HIV+ population cumulating multiple cardiovascular risk factors 9,57 , reaching non HDL-C goal defined by the NCEP-ATP III and the ACTG/IDSA lipid guidelines appears necessary to 15 manage CV risk beyond beneficial intervention on other modifiable factors such as tobacco consumption 58 . …”

Section: Discussionmentioning

confidence: 99%

“…Because classical risk factors do not account for all atherosclerosis risk in HIV+ patients, a search for non-classical could be of interest. Some of them could be directly related to HIV infection or its treatment such as duration of c-ART, time from HIV diagnosis, HIV plasma viral load or lipodystrophy [12][13][14][15] . Other ones including non-high density lipoprotein (HDL) cholesterol, Triglyceride (TG) to HDL ratio, apolipoprotein B (apoB), LDL size, inflammation or oxidative stress could be related to metabolic disorders such as metabolic syndrome (MS) and lipid triad (LT).…”

mentioning

confidence: 99%

Association of non-HDL cholesterol with subclinical atherosclerosis in HIV-positive patients

Badiou

Thiébaut

Aurillac-Lavignolle

et al. 2008

Journal of Infection

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“…Although data of Lorenz et al . support the hypothesis that HIV infection promotes early atherosclerosis independently of the ‘classical’ vascular risk factors,13 the role of HIV infection as a risk factor for premature atherosclerosis is still controversial 9,19. There is also uncertainty about the relative contribution of the viral infection, the virus itself, the associated inflammatory response, antiretroviral therapy, and the interaction between them and the cardiovascular risk factors seen in the HIV-infected population 20,21…”

Section: Introductionmentioning

confidence: 99%

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Fourie¹,

Rooyen²,

Pieters³

et al. 2011

CardioVascular Journal of Africa

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The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the infections worldwide, this subtype differs genetically from HIV-1 subtype B on which the majority of studies have been done. The objective of this study was to assess whether newly identified, never-treated, HIV-1-infected South African participants showed signs of endothelial dysfunction, accelerated atherosclerosis and increased blood coagulation.We compared 300 newly diagnosed (never antiretroviral-treated) HIV-infected participants to 300 age-, gender-, body mass index- and locality-matched uninfected controls. Levels of high-density lipoprotein cholesterol (HDL-C), triglycerides, interleukin-6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), fibrinogen and plasminogen activator inhibitor-1 (PAI-1), and carotid radialis pulse wave velocity (cr-PWV) were determined. The HIV-infected participants showed lower HDL-C and higher IL-6, CRP, ICAM-1 and VCAM-1 levels compared to the uninfected controls. No differences in fibrinogen and PAI-1 levels were detected. A continuous positive trend of increasing age with cr-PWV was detected in the HIV-infected group.Our findings suggest inflammatory injury of the endothelium, pointing to endothelial dysfunction of never-treated HIV-1-infected South Africans of African ancestry. Although no indication of a prothrombotic state could be detected, there was an indication of accelerated vascular aging and probable early atherosclerosis in the older HIV-infected participants.

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HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis: The role of monocyte chemoattractant protein-1

Cited by 46 publications

References 20 publications

Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy

Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy

Association of non-HDL cholesterol with subclinical atherosclerosis in HIV-positive patients

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

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