HIV Drug Resistance: Molecular Basis and Clinical Significance

Wainberg, Mark A.; Smith, Marilyn B. Kroeger; Montaner, Julio S. G.; Nagai, Koutatsu; Spira, Avrum; Salomón, Horacio; Gu, Zhengxian

doi:10.1159/000424945

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Nuclleoside Analog Reverse Transcri Ptase In H I Bltors1

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“…There is evidence of crossresistance with ddI and ddC; therefore, patients who have been on those agents for lengths of time may not have as good a result with 3TC. Alternatively, patients using 3TC as initial therapy may not do as well ifswitched to ddI or ddC (Wainberg, 1994). 3TC also decreases levels of hepatitis B virus; not significantly enough to use for that indication alone, but for HIV-positive patients with chronic active hepatitis B, 3TC would be a good choice of antiretroviral therapy (Benhamou, 1995).…”

Section: Nuclleoside Analog Reverse Transcri Ptase In H I Bltorsmentioning

confidence: 99%