HIV‐disease and bone marrow changes: A study of 60 cases

Abstract

We report our experience of peripheral blood and bone marrow changes in patients with HIV disease. Abnormalities were most commonly seen in patients with advanced disease. In AIDS group IV patients (CDC classification) anaemia (92%) neutropenia (85%) monocytopenia (75%) and thrombocytopenia (61%) have their highest incidence, the reason being a combination of factors such as infection, myelosuppressive drugs and HIV infection itself. Bone marrow examinations were performed most commonly for microbiological culture (25%) and the investigation of anaemia (16%). Morphological changes in the bone marrow were non‐specific and not pathognomic; however erythroid hypoplasia was found to be a distinctive feature associated with MAI infection. The procedure provided a high yield for microbiological culture, particularly in MAI infection.

Nutritional and haematological status of human immunodeficiency virus infected children

“…Mir N et al found anaemia in 92% HIV infected children. 5 In our study we observed that prevalence and severity of anaemia increases with progression of disease. Belperio et al and Shet et al also found higher prevalence of anaemia in advance stage of disease.…”

“…Most of the children present with failure to thrive and anaemia. [3][4][5][6] Severe malnutrition, chronic diarrhoea, anaemia, serious pyogenic infections, disseminated tuberculosis and oral candidiasis are associated with increased risk of being HIV positive. 7 Apart from other reasons, chronic diarrhoea is a major cause of malnutrition in HIV infected children.…”

“…Anaemia is one of the commonest haematological manifestation in HIV infected children. 5,6 Cause of anaemia and under nutrition could be multi factorial. HIV infection itself, directly or indirectly, can produce this condition.…”

Myelomonocytic Cell Lines in Modeling HIV-1 Infection of the Bone Marrow

“…HIV-1 affects the hematopoietic system, causing a number of peripheral blood cytopenias [55,56]. HIV-1-infected patients suffer from many hematologic disorders and exhibit uni or multilineage suppression of bone marrow hematopoiesis including anemia, lymphocytopenia, thrombocytopenia, granulocytopenia, monocytopenia, and neutropenia that can be attributed to malfunction or premature death of the specific hematopoietic cells [8, [57][58][59]. The hematopoietic disorders are frequently associated with impaired HPC growth, BM dysplasia, plasmacytosis, and lymphoid infiltrates [57,60], and they suggest virusinduced abnormalities in the bone marrow microenvironment [61][62][63].…”

Seguimiento farmacoterapéutico de pacientes chilenos con infección por VIH/SIDA hospitalizados en un centro de alta complejidad durante un período de un año

“…Del total de RAM hematológicas, 13,8 y 3,2% de los pacientes presentaron leucopenia con el uso de ganciclovir parenteral y zidovudina, respectivamente, y algún grado de anemia en 2,1 y 7,4% de ellos. Si bien la anemia es una complicación común y seria de la infección por VIH y de su tratamiento, sus causas suelen ser multifactoriales (inmunológicas, virológicas y características propias de los pacientes); su incidencia en pacientes infectados por VIH al momento de su admisión en el centro hospitalario varía de 63 a 95% [13][14][15] . Otros estudios han publicado una incidencia de anemia asociada a AZT que oscilan entre 10 y 35% [17][18][19][20] , en nuestro estudio hemos encontrado una baja incidencia de anemia asociada a este fármaco; sin embargo, la mayoría de los pacientes que ingresa a hospitalizarse, como los estudios señalan, lo hacen con una anemia de base que repercute en preferir como base del tratamiento anti-retroviral análogos nucleosídicos con menor riesgo de toxicidad hematológica como abacavir o tenofovir.…”