HIV co-infection among tuberculosis patients in Dabat, northwest Ethiopia

Tadesse, Sebsibe

doi:10.5897/jidi2013.0117

Cited by 20 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The socio-demographic variables of the TB/HIV patients in our study are similar to those of other researchers within and outside Nigerian state 26,28,29 . Although, majority of the TB patients were males, most of the TB/HIV co-infected were females.…”

Section: -27supporting

confidence: 86%

See 1 more Smart Citation

Five years retrospective cohort analysis of treatment outcomes of TB-HIV patients at a PEPFAR/DOTS Centre in South Eastern Nigeria

et al. 2016

View full text Add to dashboard Cite

Background: Human immunodeficiency virus (HIV) associated tuberculosis (TB) remains a major global public health challenge, with an estimated 1.4 million patients worldwide. Co-infection with HIV leads to challenges in the diagnosis and treatment of patients. Objectives: The aim of this study was to assess treatment outcomes of a cohort of smear positive TB-HIV co-infected patients over a five-year study period. Methods: A retrospective cohort study of 600 smear-positive tuberculosis patients registered at the chest unit of the University of Nigeria Teaching Hospital, Enugu from January 2008 to December 2012 was done. The data was analyzed using SPSS Version 17. Results: One hundred and three (17.2%) of the patients were co-infected with TB/HIV, while 398 (66.3%) and 99 (16.5%) were HIV negative and unknown respectively. Among the co-infected patients, 45(43.7%) were cured as against 222(55.8%) in the TB-HIV negatives (Z=4.53, p=0.000, 95%CI= 0.12-0.34). Respectively in the TB-HIV co-infected and TB-HIV negative patients, treatment completed were 21(20.4%) and 71(17.8%) (Z=9.15, p=0.000, 95%= 0.4035-0.60); defaulted 19(18.5%) vs 70 (17.6%) (Z=9.29, p=0.000, 95%CI=0.42-0.60), died 10(9.7%) vs. 6(1.5%) (Z=1.22, p=0.224, 95%CI= -0.0286-0.1086), and failures were 1(0.9%) vs. 7(1.8%) (Z=2.48, p=0.013, 95%CI=0.04-0.10). Treatment success rate was lower in TB-HIV co-infected patients, 64.1% compared to TB-HIV negative patients with 73.6%. Also those that defaulted among the TB-HIV co-infected patients (18.5%) were higher than 17.6% among TB-HIV negative patients, a difference of 0.9%. Conclusion: Findings demonstrate that HIV co-infection affects TB treatment outcomes adversely. Treatment adherence, timely and sustained access to antiretroviral therapy for TB/HIV co-infected patients are important.

show abstract

Section: -27supporting

confidence: 86%

“…This finding is also similar to studies carried out in Dabat, Ethiopia, Malawi, Cameroonian district hospital and Rwanda. 19,20,28,30 .…”

Section: -27mentioning

confidence: 99%

Five years retrospective cohort analysis of treatment outcomes of TB-HIV patients at a PEPFAR/DOTS Centre in South Eastern Nigeria

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Elsewhere, Akpaka et al [19] reported 11.6% TB and HIV co-infection in Jamaica. Also, 11.4% was found in Northwest Ethiopia [20], 55.5% in Western Kenya [9], 39.0% in Brazil [21] and 8.6% in India [22]. The fairly high prevalence of tuberculosis disease among HIV/AIDS patients seeking care and treatment in the selected health facilities in this research suggests a strong association between TB and HIV infection as posited by Tadesse and Tadesse [20].…”

Section: Discussionmentioning

confidence: 92%

“…Also, 11.4% was found in Northwest Ethiopia [20], 55.5% in Western Kenya [9], 39.0% in Brazil [21] and 8.6% in India [22]. The fairly high prevalence of tuberculosis disease among HIV/AIDS patients seeking care and treatment in the selected health facilities in this research suggests a strong association between TB and HIV infection as posited by Tadesse and Tadesse [20]. This study did not consider whether or not the HIV patients were already on Anti-Retroviral therapy, which may explain why the percentage of TB and HIV co-infection is higher than most of the other figures within Nigeria.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria

Egbe

Anthony²,

Chuku³

2016

SJPH

View full text Add to dashboard Cite

Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a clinical and public health challenge inNigeria. This study was carried out to determine the prevalence of M. tuberculosis and rifampicin resistance in patients from five selected health facilities in Nasarawa State, Nigeria. The HIV serostatus and the CD4+ count of seropositive individuals were also determined. Using a combination of Zhiel Neelsen staining and WHO approved GeneXpert MTB/Rif device for M. tuberculosis and rifampicin resistance, the presence of M. tuberculosis in sputum samples was detected and confirmed. A total of 346 samples were analysed, out of which M. tuberculosis was detected in 91 (26.3%) samples and rifampicin resistance in 6 (6.6%) of the positive samples. HIV prevalence was found to be 46.8%, HIV and TB co-infection 39.6%, while 83.3% of the rifampicin resistance was from HIV positive cases. Tuberculosis was found to be decreasing with increase in CD4 count. Statistically, there was a significant relationship (P < 0.05), between level of education, HIV, CD4 count and TB occurrence. However, no significant relationship (P > 0.05) between gender, occupation and age with TB was observed. Our results show that tuberculosis still remains endemic in Nasarawa state with a high prevalence of HIV and that the confluence of HIV and tuberculosis increased the rate of rifampicin resistance. Provision of Tuberculosis diagnostics with the capacity to detect TB drug resistance beyond rifampicin is highly recommended.

show abstract

“…Of 96245 TB patients tested for HIV infection, 9819(10%) were positive. Nevertheless, rate of co-infection among TB patients varies according to geographical location and people (Alemie and Gebreselassie 2014, Datiko et al, 2008, Tadesse and Tadesse, 2013.…”

Section: Original Researchmentioning

confidence: 99%

Tuberculosis-HIV Co-infection Rate among Smear Positive Pulmonary Tuberculosis Patients and Associated Risk Factors in Southern Ethiopia

Zeleke¹,

Tsalla²,

Shibiru³

2014

Sci. Technol. Arts Res. J.

View full text Add to dashboard Cite

Article InformationThe objective of this study was to estimate HIV infection and associated risk factors among smear positive pulmonary TB patients in Southern Ethiopia. A cross-sectional study design was used to recruit 221 consecutive smear positive pulmonary TB patients visiting three hospitals in Gamo Goffa Zone from March, 2013 to February, 2014. A structured questionnaire was used to collect data on socio demographic, behavioral and economic factors from study units. Chi-square, fisher's exact test and logistic regression were used to assess the association between the above factors and HIV infection among smear positive pulmonary TB. The rate of HIV-TB co-infection among sputum smear-positive pulmonary TB patients in southern Ethiopia was 6.8% with 95% confidence interval of 3.3 to 10.3%. Drinking alcohol was significantly associated with increased risk of HIV infection among smear positive pulmonary TB patients in univariable logistic regression but that association was not maintained after controlling for potential confounding variables. Other factors significantly associated with HIV infection among the study population were previous anti-TB treatment, being resident in urban area and participants who had monthly income of less than or equal to 1000 Ethiopian birr as compared to those who had no regular monthly income. The rate of TB-HIV infection among smear positive pulmonary TB patients in Southern Ethiopia was low. However, the government or other partner organizations should work on decreasing the burden of co-infection through designing strategy on preventing HIV transmission in the urban area; increase the monthly income of citizens while enhancing TB-HIV collaborative activity to prevent reactivation of TB.

show abstract

HIV co-infection among tuberculosis patients in Dabat, northwest Ethiopia

Cited by 20 publications

References 15 publications

Five years retrospective cohort analysis of treatment outcomes of TB-HIV patients at a PEPFAR/DOTS Centre in South Eastern Nigeria

Five years retrospective cohort analysis of treatment outcomes of TB-HIV patients at a PEPFAR/DOTS Centre in South Eastern Nigeria

Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria

Tuberculosis-HIV Co-infection Rate among Smear Positive Pulmonary Tuberculosis Patients and Associated Risk Factors in Southern Ethiopia

Contact Info

Product

Resources

About