HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease.

Roskell, Derek; Hyde, G M; Campbell, A. M. G.; Jewell, D P; Gray, W.

doi:10.1136/gut.37.1.148

Cited by 31 publications

(12 citation statements)

References 5 publications

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“…According to recent epidemiological data, patients with severe steroid-resistant UC might be at particular risk for CMV infection [10][11][12][13]. In our studies, anti-CMV IgG was confirmed in 41.7% and CMV DNA was positive in the serum of 53.3% of control patients aged 40-79.…”

supporting

confidence: 69%

“…In some patients, CMV may coexist with other infectious agents (e.g. Cryptosporidium spp., Isospora belli, Herpes simplex types 1 and 2, Mycobacterium avium-intracellular) found within the bowel [9,10,12,15]. According to previously published data, CMV infection was detected fairly frequently (21%) in the surgical specimens of UC, and such cases were steroid resistant [9,15].…”

mentioning

confidence: 93%

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Inflammatory bowel disease — is there something new in the immunological background?

Marszałek¹,

Marciniak²,

Szkaradkiewicz³

et al. 2011

Folia Histochem Cytobiol.

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Abstract: Abstract: Abstract: In the present paper we correlate clinical data, as well as histopathological, immunohistochemical and molecular biology methods, with the occurrence of both forms of inflammatory bowel disease (IBD) i.e. ulcerative colitis and Crohn's disease. We found that patients with a history of Epstein-Barr virus (EBV) or cytomegalovirus (CMV) infections, as well as steroid treatment, had increased susceptibility to the development of IBD. The diagnosis of IBD was confirmed by histopathology. Previous infections by EBV and CMV, as well as M. tuberculosis, were proved by PCR-based techniques and in situ hybridization. We found PCR-proved latent viral infections in 30-50% of the IBD patients we studied. However, we were unable to prove the presence of viral antigens by immunohistochemistry for EBV or CMV. We found positive correlations between the presence of anti-CMV IgG, as well as PCR-positive results for M. tuberculosis with an ulcerative colitis diagnosis. Additionally, up to 80% of IBD patients used steroids, which was found to be correlated with a diagnosis of Crohn's disease. Our data may support the theory that IBD could be related to previous viral infections and the use of

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supporting

confidence: 69%

mentioning

confidence: 93%

Inflammatory bowel disease — is there something new in the immunological background?

Marszałek¹,

Marciniak²,

Szkaradkiewicz³

et al. 2011

Folia Histochem Cytobiol.

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“…4 Alimentary tract CMV infections were reported as a first manifestation in acquired immunodeficiency syndrome. 6 Roskell et al 7 reported that, regardless of the age and perceived lifestyle of the patient, a diagnosis of CMV colitis in someone not known to be immunosuppressed should raise the possibility of human immunodeficiency virus (HIV) infection. We report a rare case of a healthy HIV-negative woman with CMV enterocolitis who was diagnosed by the presence of CMV inclusions in biopsy specimens of the terminal ileum.…”

mentioning

confidence: 99%

Cytomegalovirus Enterocolitis in an Immunocompetent Individual

Sakamoto

Shirai

Kamide

et al. 2002

Journal of Clinical Gastroenterology

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We report a rare case of cytomegalovirus (CMV) enterocolitis in a healthy 57-year-old woman. In March 1999, she developed hematochezia, diarrhea, and abdominal pain. Total colonoscopy on March 17th showed multiple aphthoid lesions and friable mucosa from the terminal ileum to the rectum and a shallow ulcer on the ileocecal valve. Repeat total colonoscopy on April 19th showed faded aphthoid lesions in the terminal ileum, and biopsy specimen revealed CMV inclusion bodies. Symptoms and endoscopic findings improved without any specific medication. In previous reports, the definition of "immunocompetent individual" varied. Here, we define immunocompetent individual as one who has no associated diseases, is not under immunosuppressive therapy, has no recent history of operation, is negative for human immunodeficiency virus antibody, is not pregnant, has no obvious infectious course, and is less than 70 years of age. This is the ninth report of CMV enterocolitis in an immunocompetent individual in the world literature.

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“…As an alternative explanation for the presence of CMV in ulcerative colitis tissues, the virus has a propensity to localize in inflammation areas infecting tissues of granular growth, such as ulcerative colitis ulcers or to invade areas of mucosa with preexisting inflammation, but without causing the intestinal inflammatory illness 6,15 . Finally, mononuclear cells loading latent phase CMV could be attracted to the ulcerative colitis inflammation and to concentrate locally the viral DNA 15 . Thus, CMV infection could be a causative of ulcerative colitis or to occur as a consequence of ulcerative colitis injuries in the intestinal mucosa.…”

mentioning

confidence: 99%

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

Mariguela

Chachá

Cunha

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYCytomegalovirus (CMV) is a genus in the family Herpesviridae that has been associated with gastrointestinal syndromes. In this work we looked for a possible association of CMV infection with colorectal cancer and ulcerative colitis (UC). Blood and enteric tissue samples of 14 patients with colorectal cancer and of 21 with UC were subjected to a nested-PCR that amplifies part of the gB gene of CMV and also to immunohistochemistry using a specific monoclonal antibody to IE 76kDa protein of CMV. CMV was detected by nested-PCR in the blood and/or the enteric tissue of nine (64.3%) colorectal cancer and 16 (76.2%) ulcerative colitis patients. In the immunohistochemistry it was observed that 12 (12/21, 57.1%) positive enteric tissue samples of patients with UC and none from patients with colorectal cancer (0/14) were positive to CMV. The positivity of CMV infections in the UC patient group (12/21, 57.1%) showed by both techniques, was significantly higher (p = 0.015) than that observed for colorectal cancer patients (2/14, 14.3%). These results suggest an association of ulcerative colitis with CMV infection of the enteric tissue.

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HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease.

Cited by 31 publications

References 5 publications

Inflammatory bowel disease — is there something new in the immunological background?

Inflammatory bowel disease — is there something new in the immunological background?

Cytomegalovirus Enterocolitis in an Immunocompetent Individual

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

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HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease.

Cited by 31 publications

References 5 publications

Inflammatory bowel disease &#8212; is there something new in the immunological background?

Inflammatory bowel disease &#8212; is there something new in the immunological background?

Cytomegalovirus Enterocolitis in an Immunocompetent Individual

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

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Product

Resources

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Inflammatory bowel disease — is there something new in the immunological background?

Inflammatory bowel disease — is there something new in the immunological background?