HIV- and FIV-Derived gp120 Alter Spatial Memory, LTP, and Sleep in Rats

Sanchez‐Alavez, Manuel; Criado, José R.; Gómez-Chavarı́n, Margarita; Jiménez-Anguiano, Anabel; Navarro, Luz; Diaz-Ruiz, Oscar; Galicia-Castillo, Oscar; Sánchez-Narváez, Francisco; Murillo-Rodrı́guez, Eric; Henriksen, Steven J.; Elder, John H.; Prospéro-Garcı́a, Oscar

doi:10.1006/nbdi.2000.0302

Cited by 30 publications

(13 citation statements)

References 51 publications

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“…The toxic effect of gp120 on neurons has well been demonstrated (Dreyer et al 1990;Kanmogne et al 2002). Studies have shown that bilateral injection of 10-100 nM gp120 into the intermediate medial mesopallium of the chick forebrain causes amnesia, while several other studies shown that gp120 impairs memory retention in rodents (Glowa et al1992;Pugh et al 2000;Sanchez-Alavez et al 2000). Similarly, our previous experiment revealed that the V3 loop peptide produces an inhibition of LTP (Dong and Xiong 2006), a robust and longlasting form of synaptic plasticity, which is widely considered a leading candidate for the cellular mechanism of mammalian learning and memory (Bliss and Collingridge 1993).…”

Section: Discussionmentioning

confidence: 97%

Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats

Tang

Pan

et al. 2009

Life Sciences

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Section: Discussionmentioning

confidence: 97%

Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats

Tang

Pan

et al. 2009

Life Sciences

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“…Investigators have suggested that the cognitive deficits observed in these studies are associated with significant increases in astrogliosis and microgliosis, a possible explanation for our findings (Griffin et al 2004). Additionally, there is evidence in Tat-mice (Fitting et al 2008; personal communication) or with gp120 treatment (Sanchez-Alavez et al 2000) there are impairments in the induction and maintenance of long-term potentiation (LTP) of the hippocampus interfering with spatial learning and memory (Table 1). …”

Section: Discussionmentioning

confidence: 99%

“…Table 1 summarizes some of the evidence that spatial learning and memory impairments occur as a consequence of expression of HIV-1 and its related proteins in rodent models using the MWM (D’Hooge et al 1999; Glowa et al 1992; Griffin et al 2004; Tang et al 2009; Zink et al 2002). Rodent HIV models also tend to show impairment in the Barnes maze (Sanchez-Alavez et al 2000), radial arm maze (Li et al 2004), and radial arm water maze (Keblesh et al 2009) (Table 1). However, it has been questioned how well the MWM translates to learning and memory tests typically used in in humans.…”

Section: Introductionmentioning

confidence: 99%

Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women

et al. 2012

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HIV-associated neurocognitive disorders (HAND) continue to be a neurological complication of HIV infection in the era of combined antiretroviral therapy (cART). Hippocampal neurodegeneration and dysfunction occurs as a result of HIV infection, but few studies to date have assesses spatial learning and memory function in patients with HAND. We used the Memory Island (MI) Test to study the effects of HIV infection, Apolipoprotein E (ApoE) allele status, and CSF ApoE protein levels on spatial learning and memory in our cohort of Hispanic women. The MI Test is a virtual reality-based computer program that tests spatial learning and memory, and was designed to resemble the Morris Water Maze (MWM) test of hippocampal function widely used in rodent studies. In the current study, HIV-seropositive women (n=20) and controls (n=16) were evaluated with neuropsychological (NP) tests, the MI Test, ApoE, and CSF ApoE assays. On the MI, the HIV-seropositive group showed significant reduced learning and delayed memory performance compared with HIV-seronegative controls. When stratified by cognitive performance on NP tests, the HIV-seropositive, cognitively impaired group performed worse than HIV-seronegative controls in ability to learn and in the delayed memory trial. Interestingly, differences were observed in the results obtained by the NP tests and the MI Test for ε4 carriers and non-carriers: NP tests showed effects of the ε4 allele in HIV-seronegative women but not HIV-seropositive ones, whereas as the converse was true for the MI Test. Our findings suggest that the MI test is sensitive in detecting spatial deficits in HIV-seropositive women, and that these deficits may arise relatively early in the course of HAND.

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“…These animals also develop impairments in hippocampal long term potentiation (Krucker et al, 1998). Moreover, administration of gp120 in rats evokes brain injury (Bagetta et al, 1996;Bansal et al, 2000;Maccarone et al, 2000), impairments in spatial memory (Glowa et al, 1992;Sanchez-Alavez et al, 2000), and contextual fear conditioning (Pugh et al, 2000). Gp120-induced neurotoxicity has also been demonstrated in vitro (Lipton et al, 1991;Dawson et al, 1993;Savio and Levi 1993;Bennett et al, 1995;Meucci and Miller, 1996;Kaul and Lipton, 1999;Bachis et al, 2003).…”

Section: Introductionmentioning

confidence: 93%

Human Immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases

et al. 2003

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Human immunodeficiency virus type 1 (HIV-1)infection of the central nervous system is associated with microglia activation and neuronal apoptosis, alterations that are also caused by the HIV-1 envelope glycoprotein 120 (gp120) alone. This study was undertaken to examine the onset of gp120 neurotoxicity, the type of cell death and which cells of the adult rat brain are more sensitive to the toxic action of gp120. Gp120 or vehicle were injected chronically (daily for 3 or 7 days) into the lateral ventricle. Magnetic resonance imaging revealed hypertensive areas in the cortical and hippocampal gray matter in gp120-treated rats 7-10 days after the first injection, suggesting vasogenic edema. This phenomenon was accompanied by an enlargement of the lateral and third ventricles. Immunohistochemical analyses were then carried out to examine the toxic effect of gp120 at a cellular level. Several markers of apoptosis, including activated caspase-3 were observed at both 3 and 7 days throughout brains of gp120-treated rats, especially in the cerebral cortex. In this area, most of the apoptotic cells exhibited a pyramidal shape and were Nissl positive, indicative of neurons. Few non-neuronal cells exhibited signs of apoptosis. The results of the present study support the notion that gp120 is neurotoxic in vivo and provide evidence that gp120 activates a caspasedependent apoptotic pathway.

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HIV- and FIV-Derived gp120 Alter Spatial Memory, LTP, and Sleep in Rats

Cited by 30 publications

References 51 publications

Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats

Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats

Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women

Human Immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases

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