HIV and Anxiety

O’Cleirigh, Conall; Hart, Trevor A.; James, Carolyn A.

doi:10.1007/978-0-387-74753-8_12

Cited by 2 publications

(1 citation statement)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Psychological distress, including psychiatric disorders and subthreshold symptoms, is prevalent among PWH 24–29 and further contributes to chronic inflammation through direct (ie, biological immune response and sympathetic nervous system activity) 30,31 and indirect (ie, proinflammatory behavioral) mechanisms. 11–14,32–36 Psychobehavioral interventions targeting psychological distress may therefore reduce CVD risk through supporting biological and behavioral changes among PWH.…”

Section: Introductionmentioning

confidence: 99%

Brief Report: Evaluating the Efficacy of Psychobehavioral Interventions for Cardiovascular Risk Among People Living With HIV: A Systematic Review and Meta-Synthesis of Randomized Controlled Trials

Foley,

Bernier,

Ngo

et al. 2024

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

People with HIV (PWH) are disproportionately affected by cardiovascular disease (CVD). Psycho-behavioral therapies are capable of targeting the pathophysiology underlying HIV-CVD comorbidity. This study synthesized findings from randomized controlled trials (RCTs) of psycho-behavioral therapies for reducing CVD risk among PWH following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were: (1) utilized an RCT design, (2) evaluated a cognitive-behavioral or mindfulness-based therapy, (3) sampled adults (age ≥18 years) with HIV, (4) measured a behavioral (e.g., diet) or biological (e.g., immune functioning) CVD risk factor, and (5) published in an English-language peer-reviewed journal. Electronic searches were conducted in six databases (e.g., MEDLINE) using controlled vocabulary and free-text synonyms for HIV, psycho-behavioral therapy, and CVD risk. Data were independently extracted with consensus reached. Outcomes were immune activation, tobacco-smoking, stress, inflammation, and physical activity from 33 studies. There were stronger effects for psycho-behavioral interventions compared to controls on CD4 (Hedge’s g=0.262, 95% Confidence Interval [CI]=0.127, 0.396) and tobacco-smoking abstinence (Hedge’s g=0.537, 95% CI=0.215, 0.86). There were no differences or insufficient data for stress, inflammation, or physical activity. No eligible studies examined psycho-behavioral interventions on blood pressure, lipids, or weight in PWH. There is increasing importance to further invest in broader CVD risk reduction effort for PWH that include psycho-behavioral intervention strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Brief Report: Evaluating the Efficacy of Psychobehavioral Interventions for Cardiovascular Risk Among People Living With HIV: A Systematic Review and Meta-Synthesis of Randomized Controlled Trials

Foley,

Bernier,

Ngo

et al. 2024

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

show abstract

Optimizing the effects of stress management interventions in HIV.

O’Cleirigh¹,

Safren²

2008

Health Psychology

View full text Add to dashboard Cite

Scott-Sheldon, Kalichman, Carey, and Fiedler (2008) present a thoughtful, important, and timely meta-analysis of randomized controlled trials of stress management interventions in HIV. They differentiate controlled effect sizes across classes of acute outcomes including psychological distress, psychosocial processes, biological processes (immune status, viral, and hormonal) and fatigue. The authors join Scott-Sheldon et al., in considering future directions for this type of clinical psychosocial intervention research in HIV. Recommendations for addressing the high prevalence of psychosocial problems including diagnosable mental health disorders comorbid with HIV are presented. Suggestions for addressing medication adherence and accommodating interventions with concomitant substance use treatment are also considered. These recommendations are presented with an emphasis on expanding both the efficacy and effectiveness of psychosocial interventions in HIV. These recommendations are presented as realistic strategies for improving the modest treatment effect sizes for psychosocial outcomes and identifying meaningful effects on distal physiological outcomes associated with traditional stress management interventions in HIV. Keywords stress management interventions; HIV; immunity; psychopathology; psychoneuroimmunologyThere is a large and growing body of literature identifying the deleterious health and immune consequences of disease-related and other stressors in people living with HIV (see Leserman, 2003, for a review). It is likely that stress contributes to poor disease outcomes by interfering with the adaptive management of HIV and through chronic activation of the hypothalamic-pituitary-adrenal and the sympathetic-adrenal-medullary systems with associated down-regulation of the immune system. Stress may compromise adaptive management of HIV through its association with increased rates of psychological distress and impaired execution of health behaviors. In light of the results of the meta-analysis presented by Scott-Sheldon, Kalichman, Carey, and Fiedler (2008), we consider these pathways with respect to future developments of stress management interventions in HIV that may assist with demonstrations of efficacy and effectiveness. Stress Management and PsychopathologySpecifically, stress has been associated with higher levels of symptoms of depression (e.g.,

show abstract

HIV and Anxiety

Cited by 2 publications

References 116 publications

Brief Report: Evaluating the Efficacy of Psychobehavioral Interventions for Cardiovascular Risk Among People Living With HIV: A Systematic Review and Meta-Synthesis of Randomized Controlled Trials

Brief Report: Evaluating the Efficacy of Psychobehavioral Interventions for Cardiovascular Risk Among People Living With HIV: A Systematic Review and Meta-Synthesis of Randomized Controlled Trials

Optimizing the effects of stress management interventions in HIV.

Contact Info

Product

Resources

About