HIV and Aging in Mainland China: Implications for Control and Prevention Research

He, Na; Ding, Yingying; Li, Jing; Yuan, Shiying; Xu, Lulu; Qiao, Shijie; Xu, Xiaohui; Zhu, Bowen; Shi, Richard; Barile, John P.; Wong, Frank

doi:10.1007/s11904-019-00473-2

Cited by 10 publications

(6 citation statements)

References 55 publications

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“…Furthermore, cognitive disorders, loneliness, shame and depression may increase the likelihood that they fail to follow their drug regimen, or refuse treatment altogether ( Greene et al, 2018 ; Vincent et al, 2017 ). Interestingly, HIV infection is also likely a driver of early ageing, as AIDS patients age more rapidly than the general healthy population ( He et al, 2019b ; Lin et al, 2019 ). To address these problems, the diagnostic process in the aged population should be addressed more cautiously; therapeutic drugs and technologies suitable for the elderly patients should be developed.…”

Section: Primary Challenges For the Elderly In Chinamentioning

confidence: 99%

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

Fang

Xie

Schenkel

et al. 2020

Ageing Research Reviews

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332

191

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Highlights Covered broad fields of ageing in China: statistics, basic and translational research, long-term care, policy and social networks. Provided more detailed numerical updates of the ageing challenges in China. New features of the aging-related challenges, e.g., oral ageing and STDs in the elderly in China. A new and independent section on immune ageing. We also mentioned the COVID-19-induced death in the Chinese elderly.

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Section: Primary Challenges For the Elderly In Chinamentioning

confidence: 99%

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

Fang

Xie

Schenkel

et al. 2020

Ageing Research Reviews

Self Cite

332

191

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“…The wide use of antiretroviral therapy (ART) had led to HIV becoming a manageable chronic disease [1]. However, people living with HIV continue to experience early onset and an elevated risk of non‐communicable diseases [2]. It is noteworthy that liver fibrosis (LF) and related complications have become the major disease burden and cause of death for people living with HIV [3].…”

Section: Introductionmentioning

confidence: 99%

Microbial translocation is associated with advanced liver fibrosis among people with HIV

Shi

Duan

et al. 2022

HIV Medicine

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Background:The prevalence of liver complications is increasing among people living with HIV, and microbial translocation (MT) might play a vital role. We conducted a prospective cohort study to evaluate the association between plasma biomarkers of MT and liver fibrosis (LF) among people living with HIV in southwest China.Method: A total of 665 people living with HIV were enrolled at baseline and had at least one follow-up visit during the 3-year study period. We calculated the Liver Fibrosis Index (FIB-4) to evaluate LF and measured plasma soluble CD14 (sCD14) and lipopolysaccharide-binding protein (LBP) as surrogate biomarkers for MT. We used ordinal logistic regression to investigate correlates of LF at baseline and used a linear mixed model to examine the association between dynamic changes in MT biomarkers and LF.Results: Of the participants, 61 (9.17%) had advanced LF (FIB-4 >3.25), and 193 (29.02%) had moderate LF (1.45 ≤ FIB-4 ≤ 3.25). Patients with advanced LF had higher plasma levels of sCD14 and LBP than those with moderate or no LF, both at baseline and at follow-up. The following factors were significantly associated with advanced LF: the highest quartile of LBP (adjusted odds ratio[aOR] = 1.69; 95% confidence interval [CI] 1.02~2.81), current intravenous drug use (aOR = 1.82; 95% CI 1.06~3.12), baseline CD4 <200 cells/μl (aOR = 3.25; 95% CI 2.13~4.95), hepatitis C virus coinfection (aOR = 2.52; 95% CI 1.41~4.51) and age >50 years (aOR = 32.66; 95% CI 15.89~66.36). LF progression (increasing FIB-4) was significantly associated with increasing sCD14 level (β = 1.11; 95% CI 0.97~1.26; p < 0.001) with covariate adjustment. Conclusion:The significant relationship between MT and LF may reveal pathogenic mechanisms and potential intervention targets of liver complications among people living with HIV in China.

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“…Notably, there is a biological, functional, and psychological decline and risk of disease in the process of ageing [ 2 ]. Ageing is associated with a decline in the body's capacity to respond to stress, and this makes the aged more prone to infectious diseases such as the human immunodeficiency virus (HIV) [ 3 , 4 ]. In this regard, well nutritional therapy is a vital adjunct in the care of the aged living with HIV.…”

Section: Introductionmentioning

confidence: 99%

Aged Persons Living with HIV and Nutritional Wellness: Analysis of 2013 South Africa-SAGE Well-Being of Older People Study (WOPS) Wave 2

Oduro

Kissah-Korsah

2021

Journal of Aging Research

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Introduction. This study sought to examine the nutritional wellness among aged persons living with HIV in Somkhele, South Africa. Methods. Data were extracted from the 2013 South Africa-SAGE Well-Being of Older People Study (WOPS) Wave 2. The study sampled 440 aged persons (50 years and above). The proportion of the aged persons with high nutritional wellness by key covariates was reported with chi-square and p -values ( p < 0.05 ). Two-level binary logistic regression models were fitted. Results. Results show that there were more aged women (79.8%) than men (20.2%) and the younger old (50–64) dominated (65.7%) in the ages, among the respondents. A higher percent of the aged persons were widows (39.5%) and had no formal education (46.1%). Six in 10 aged persons were HIV infected (59.5%). Percentage distribution of men with high nutrition was higher (78.7%). Regression results show that having nutritional wellness was low for aged persons who were infected by HIV (OR = 0.74, 95% CI = 0.69, 1.26) when compared to those who were not infected. Regarding ages of respondents, having high nutritional wellness was higher for young old (65–74 years) (OR = 1.21, 95% CI = 0.65, 2.25) compared to younger old (50–64 years). Conclusion. This study suggests that age, education, source of drinking water, household source of income, and financial situation are important for nutritional wellness of aged persons who are HIV infected in South Africa. Moreover, having HIV infection is associated with low nutritional wellness. Being a young old (65–74 years) and receiving government grants and with better financial situation is associated with high nutritional wellness. Stakeholders and agencies who have interest in aged persons affected by HIV must understand the socioeconomic status in relation to their nutritional wellness. The results are of great importance to ageing policies, specifically in health and nutrition.

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HIV and Aging in Mainland China: Implications for Control and Prevention Research

Cited by 10 publications

References 55 publications

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

Microbial translocation is associated with advanced liver fibrosis among people with HIV

Aged Persons Living with HIV and Nutritional Wellness: Analysis of 2013 South Africa-SAGE Well-Being of Older People Study (WOPS) Wave 2

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