HIV/AIDS Case Histories: Acute Leukemia in an AIDS Patient

Monroe, Julie; Godwin, Janice H.

doi:10.1089/108729100317849

Cited by 4 publications

(11 citation statements)

References 7 publications

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“…HIV was probably a risk factor for the development of AMLinourpatient.Studiesofbonemarrowspecimenshave shownthatmyelodysplasiaisacommoncomplicationofHIV, andreportsofHIVpatientsdevelopingeachoftheFABclassification AML subtypes indicates that this association is probablynotcoincidental [4,6,[8][9][10].Themajorityofthese …”

Section: Discussionmentioning

confidence: 99%

“…casereportsandsmallseriesoccurredduringthepre-HAART period,indicatingapossibleroleforimmunodeficiencyinthe developmentofAML,withthemonocytotropismofHIVand chronic cytokine activation of monocytes and macrophages maybeexplainingthisassociation.Whilenon-Hodgkin'slymphoma occurs frequently in conjunction with AIDS illness, thepathogeneticlinksbetweenAMLandHIVhavenotyet been fully established [2,4,7,9,[11][12][13][14][15], and it is likely that therewereadditionalleukemogenicpathwaysinoperation [2]. The use of induction chemotherapy is a reasonable treatmentoptioninHIVpatientswithAML,andcompleteremission can be achieved.…”

Section: Case Reportmentioning

confidence: 99%

“…The use of induction chemotherapy is a reasonable treatmentoptioninHIVpatientswithAML,andcompleteremission can be achieved. Allogeneic stem cell transplantation mayalsorepresentapotentialtreatmentmodalitytocontrol boththeHIVinfectionandAML [10].ThoughtheHIVinfection does not directly influence the treatment outcomes of AML, leukemia relapse rates are very high [2,[6][7][8][9]11], and therecanbedifficultiesintheadministrationofconsolidation and maintenance chemotherapy. In our particular case, the chemotherapy may have actually accelerated the natural courseoftheHIVinfection,whichinturnmayhaveprovoked an early exacerbation of the disease and led to the rapid demiseofthepatient.…”

Section: Case Reportmentioning

confidence: 99%

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Alveolar Granulocytic Sarcoma of the Mandible in a Patient with HIV

Čolović¹,

Jurišić²,

Terzić³

et al. 2011

Oncol Res Treat

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Background: Granulocytic sarcoma (chloroma) occurs primarily in patients with acute myelogenous leukemia although it can also appear in connection with other myeloproliferative disorders. Case Report: We present the case of a 52-year-old human immunodeficiency virus (HIV)-positive female patient with a CD4+ count of 321 cells/ml, who developed an alveolar granulocytic sarcoma of the mandible. Pathological analysis of the tumor mass showed an infiltrate of immature cells which were positive for CD13, CD33, CD15, CD11b, and CD64, and negative for CD34, CD117, and HLA-DR. The patient achieved complete remission following a 1-week course of chemotherapy, however, 7 months later she developed a second granulocytic sarcoma in the left soleus muscle. The absolute CD4+ count had now reduced to 3 cells/ml with an inversion in the Th/Ts index (0.01), and she died of gram-negative sepsis 1 month later. Conclusions: Granulocytic sarcoma is extremely rare in patients with HIV. The case is discussed with reference to the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Alveolar Granulocytic Sarcoma of the Mandible in a Patient with HIV

Čolović¹,

Jurišić²,

Terzić³

et al. 2011

Oncol Res Treat

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“…The occurrence of acute myelogenous leukemia (AML) in HIV-infected patients is extremely rare with about 53 cases (all adults) reported so far [1][2][3][4][5]. Most hematological malignancies in HIV-infected patients are non-Hodgkin's lymphomas and lymphoblastic leukemia [1,2,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Most hematological malignancies in HIV-infected patients are non-Hodgkin's lymphomas and lymphoblastic leukemia [1,2,4,5]. Pediatric HIV-infected patient developing AML has not been described in the literature till date.…”

Section: Introductionmentioning

confidence: 99%

Acute myelogenous leukemia in a child with HIV infection

et al. 2009

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The occurrence of acute myelogenous leukemia (AML) in HIV-infected patients is extremely rare with only adult patients reported so far. Our patient was a 7-year-old male who presented with fever and cough since 1 month with six episodes of intermittent hemoptysis. The child also had recurrent parotid swellings, melena, and purulent otitis media. Investigations revealed anemia (hemoglobin of 8.9 g/dl), thrombocytopenia (platelet count of 21,000 cells per microliter), and positive HIV antibody (perinatal transmission). The patient's bone marrow aspiration and biopsy suggested AML, and the leukemia panel 1 study showed CD13, CD33, CD34, and HLA DR-positive AML with CD7 expression. The child was given supportive treatment but succumbed to the disease. AML can occur in pediatric patients with HIV infection. A high index of suspicion of hematological malignancies should be kept in mind for patients presenting with cytopenias. This is the first HIV-infected pediatric patient (<12 years) with AML reported in the medical literature.

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Advanced acute myelogenous leukaemia (AML) during HAART-treated HIV disease, manifesting initially as a thyroid mass

Manfredi

Sabbatani

Chiodo

2005

Scandinavian Journal of Infectious Diseases

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A rare case report of acute myelogenous 46 XY, inv(16)(p13q22) leukaemia occurring in a patient with his HIV infection controlled by highly active antiretroviral therapy is reported, in the context of a review of the available literature evidences. The initial localization as an isolated thyroid mass has no clinical equivalents to date. Although at its initial presentation the haematological disease had a very advanced (M5) stage expressing a predominant monocytic phenotype, two 1-week cytotoxic chemotherapy cycles carried out with cytarabin-daunorubicin, achieved complete remission (as assessed by combined diagnostic imaging, and repeated bone marrow studies). At the present 11-month follow-up time, eventual bone marrow transplantation is under evaluation, since the chromosomal translocation was still present. A such favourable clinical response to acute, advanced myelogenous leukaemia with an insidious recognition is considered infrequent, especially in the setting of HIV disease.

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HIV/AIDS Case Histories: Acute Leukemia in an AIDS Patient

Cited by 4 publications

References 7 publications

Alveolar Granulocytic Sarcoma of the Mandible in a Patient with HIV

Alveolar Granulocytic Sarcoma of the Mandible in a Patient with HIV

Acute myelogenous leukemia in a child with HIV infection

Advanced acute myelogenous leukaemia (AML) during HAART-treated HIV disease, manifesting initially as a thyroid mass

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