HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007–12: impact on susceptibility to first-line strategies

Abstract

Compared with our previous studies, the proportion of NRTI- and first-generation NNRTI-related TDR has continued to decline in French seroconverters. However, subtype B-infected MSM could drive the spread of resistant HIV strains. Finally, we suggest preferring PI- or II- to NNRTI-based combinations to treat PHI patients.

Disparities in HIV‐1 transmitted drug resistance detected by ultradeep sequencing between men who have sex with men and heterosexual populations

“…Otherwise, UDS showed a higher frequency of TDR in subtype B vs. subtype non-B viruses among MSM patients. This is consistent with previous findings obtained using Sanger sequencing in the Odyssee study in antiretroviral-na€ ıve chronically HIV-infected patients and in a study in French patients diagnosed at the time of primary HIV-1 infection [2,13].…”

The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004

“…There was different prevalence of resistance among subtype B, CRF_01AE and CRF_07BC/08BC. Resistance was significantly higher in ARV-naïve patients who were infected with subtype B than in those infected with CRF01_AE viruses ( p  = 0.0030), which was similar with previously published studies [17–19, 31, 32]. Although subtypes may vary in mutational pathways, it is unclear whether subtype B was more prone to mutation [33].…”

Impact of genotypic susceptibility score on cART outcomes during primary HIV infection

“…The choice of the cART in the absence of the result of the resistance test is based on regimens with high genetic barrier. In fact, there is a possibility of transmission of viral resistant strains during PHI although it appears to be declining in recent years after the introduction of the integrase inhibitors . During PHI, even though R5 viruses predominate, also X4 tropic viruses can be transmitted but their real impact on disease progression remains unclear …”

“…In fact, there is a possibility of transmission of viral resistant strains during PHI 7 although it appears to be declining in recent years after the introduction of the integrase inhibitors. 8 During PHI, even though R5 viruses predominate, also X4 tropic viruses can be transmitted but their real impact on disease progression remains unclear. 9 Genotypic susceptibility score (GSS) of the antiretroviral regimen built in accordance to Stanford HIV database genotypic resistance interpretation system could be a helpful tool to assess the activity of the single antiretroviral drugs composing an antiretroviral regimen.…”