HIV-1 Structural Proteins or Cell-Signaling Factors? That Is the Question!
Michele Pellegrino,
Francesca Giordano,
Francesca De Amicis
et al.
Abstract:The biological activity of structural HIV-1 proteins is not limited to ensuring a productive viral infection but also interferes with cellular homeostasis through intra- and extracellular signaling activation. This interference induces genomic instability, increases the lifespan of the infected cell by inhibiting apoptosis, and subverts cell senescence, resulting in unrestricted cell proliferation. HIV structural proteins are present in a soluble form in the lymphoid tissues and blood of infected individuals, … Show more
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