HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages

Fujiwara, Mamoru; Takiguchi, Masafumi

doi:10.1182/blood-2006-07-037481

Cited by 34 publications

(41 citation statements)

References 34 publications

(47 reference statements)

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“…While many studies have focused on the control of viral replication in CD4 ϩ T cells, a few studies have looked at the ability of human T cell clones to kill macrophages. As with CD8 ϩ cytotoxic T cell clones and monocyte and dendritic cell targets (53), Nef-specific cytotoxic CD4 ϩ T cells were found to be capable of efficiently killing both CD4 ϩ T cell and macrophage targets (28,29). Similarly, in the macaque model of elite suppression, CD4…”

Section: Discussionmentioning

confidence: 99%

“…ϩ and CD4 ϩ T cell clones and cell lines have previously been shown to suppress HIV-1 or simian immunodeficiency virus (SIV) replication in infected macrophages (27)(28)(29)(30), less is known about the inhibitory capacity of unstimulated primary T cells. Interestingly, in the macaque model of elite suppression, freshly isolated SIV-specific primary CD8 ϩ T cells were able to inhibit viral replication in CD4 ϩ target cells but not in macrophages (31).…”

Section: While Some Cd8mentioning

confidence: 99%

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Comparative Analysis of the Capacity of Elite Suppressor CD4 ⁺ and CD8 ⁺ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Walker-Sperling

Buckheit

Blankson

2014

J Virol

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Section: Discussionmentioning

confidence: 99%

Section: While Some Cd8mentioning

confidence: 99%

Comparative Analysis of the Capacity of Elite Suppressor CD4 ⁺ and CD8 ⁺ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Walker-Sperling

Buckheit

Blankson

2014

J Virol

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“…HIV-specific CD8 ϩ cytotoxic T cells have previously been shown to suppress viral replication in macrophages by direct lysis and reduction of Gag p27 production in infected cells (26). Therefore, to monitor T cell-mediated elimination of infected macrophages, we measured the reduction of Gag p27 staining in infected MDM after coculture with SIV-specific T cells.…”

Section: Siv-specific Cd4 ؉ T Cells Eliminate Siv-infected Macrophagementioning

confidence: 99%

Gag- and Nef-specific CD4⁺T cells recognize and inhibit SIV replication in infected macrophages early after infection

Sacha¹,

Giraldo-Vela²,

Buechler³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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The precise immunological role played by CD4 ؉ T cells in retroviral infections is poorly defined. Here, we describe a new function of these cells, the elimination of retrovirus-infected macrophages. After experimental CD8 ؉ cell depletion, elite controlling macaques with set-point viral loads <500 viral RNA copies/mL mounted robust Gagand Nef-specific CD4 ؉ T cell responses during reestablishment of control with >54% of all virus-specific CD4 ؉ T cells targeting these 2 proteins. Ex vivo, these simian immunodeficiency virus (SIV)-specific CD4 ؉ T cells neither recognized nor suppressed viral replication in SIV-infected CD4 ؉ T cells. In contrast, they recognized SIV-infected macrophages as early as 2 h postinfection because of presentation of epitopes derived from virion-associated Gag and Nef proteins. Furthermore, virus-specific CD4 ؉ T cells displayed direct effector function and eliminated SIV-infected macrophages. These results suggest that retrovirus-specific CD4 ؉ T cells may contribute directly to elite control by inhibiting viral replication in macrophages.antigen processing and presentation ͉ HIV

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“…This finding also suggests that 3R virus-infected CD4 ϩ T cells were not the main source of antigen-presenting cells in 3R virus-infected individuals. A previous study showed that HIV-1-infected macrophages effectively present HIV-1 epitopes more than HIV-1-infected CD4 ϩ T cells (14), implying that 3R virus-infected macrophages are the main antigenpresenting cells and contribute to the elicitation of 3R-specific and cross-reactive CTLs in 3R virus-infected individuals. A further study should clarify the role of macrophages in the elicitation of 3R-specific and cross-reactive CTLs in 3R virus-infected individuals.…”

Section: Discussionmentioning

confidence: 99%

Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes

Akahoshi

Chikata

Tamura

et al. 2012

J Virol

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It is known that cytotoxic T lymphocytes (CTLs) recognizing HIV-1 escape mutants are elicited in HIV-1-infected individuals, but their role in the control of HIV-1 replication remains unclear. We investigated the antiviral ability of CTLs recognizing the HLA-A‫-20:42ء‬restricted Gag28 -36 (KYKLKHIVW) epitope and/or its escape mutant (KYRLKHIVW) elicited in the early and chronic phases of the infection. Wild-type (WT)-epitope-specific CTLs, as well as cross-reactive CTLs recognizing both WT and K30R (3R) epitopes, which were predominantly elicited at early and/or chronic phases in HLA-A‫20:42ء‬ ؉ individuals infected with the WT virus, suppressed the replication of the WT virus but failed to suppress that of the 3R virus, indicating that the 3R virus was selected by these 2 types of CTLs. On the other hand, cross-reactive and 3R-specific CTLs, which were elicited in those infected with the 3R virus, did not suppress the replication of either WT or 3R virus, indicating that these CTLs did not contribute to the control of 3R virus replication. High accumulation of the 3R mutation was found in a Japanese population recently recruited. The selection and accumulation of this 3R mutation resulted from the antiviral ability of these Gag28-specific CTLs and high prevalence of HLA-A‫20:42ء‬ in a Japanese population. The present study highlighted the mechanisms for the roles of cross-reactive and mutant-epitope-specific CTLs, as well as high accumulation of escape mutants, in an HIV-1-infected population.

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HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages

Cited by 34 publications

References 34 publications

Comparative Analysis of the Capacity of Elite Suppressor CD4 ⁺ and CD8 ⁺ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Comparative Analysis of the Capacity of Elite Suppressor CD4 ⁺ and CD8 ⁺ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Gag- and Nef-specific CD4⁺T cells recognize and inhibit SIV replication in infected macrophages early after infection

Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes

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HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages

Cited by 34 publications

References 34 publications

Comparative Analysis of the Capacity of Elite Suppressor CD4 + and CD8 + T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Comparative Analysis of the Capacity of Elite Suppressor CD4 + and CD8 + T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Gag- and Nef-specific CD4+T cells recognize and inhibit SIV replication in infected macrophages early after infection

Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes

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Comparative Analysis of the Capacity of Elite Suppressor CD4 ⁺ and CD8 ⁺ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Comparative Analysis of the Capacity of Elite Suppressor CD4 ⁺ and CD8 ⁺ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

Gag- and Nef-specific CD4⁺T cells recognize and inhibit SIV replication in infected macrophages early after infection