Abstract:The protective function of mucosal HIV-1- or SIV-specific antibodies against viral
infection has stimulated extensive studies of their Ig isotype association with differences in specificity
and in effector functions. In contrast to many mucosally acquired microbial infections in which the
humoral responses are dominated by induction of secretory IgA (S-IgA), HIV-1/SIV infections
stimulate vigorous IgG responses in sera as well as in external secretions but low IgA virus-specific
antibodies although the total l… Show more
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