HIV-1 infection of human placental villous tissue in vitro

Polliotti, Bruno; Sheikh, Asad U.; Subbarao, Shambavi; Keesling, S.; Lee, George R.; Caba, Joseph; Panigel, M; Reichman, Richard C.; Nahmias, André J.; Miller, Richard K.

doi:10.1016/s0143-4004(98)80044-1

Cited by 7 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HIV-1 can replicate in the placenta and it has been detected in placental cells in vivo 35 , and data from several groups indicate that HIV-1 can infect ex vivo placental explant cultures 36, 37 . Our previous work has shown that the placenta represents a unique and hospitable niche for HIV-1 replication; specifically, we observed that the concentration of HIV-1 in the placenta was different than the concentration of HIV-1 in peripheral blood 13 .…”

Section: Discussionmentioning

confidence: 99%

Severity of Maternal HIV-1 Disease Is Associated With Adverse Birth Outcomes in Malawian Women

Turner¹,

Tabbah²,

Mwapasa³

et al. 2013

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

Background Compared to HIV-negative women, HIV-infected women have increased risk of low birth weight (LBW) and preterm delivery (PTD). We assessed whether severity of maternal HIV-1 disease was associated with LBW or PTD. Methods Secondary analysis of The Malaria and HIV in Pregnancy prospective cohort, which enrolled HIV-positive, pregnant Malawian women from 2000–2004. Included participants (n=809) were normotensive, antiretroviral treatment naïve women who delivered a live, singleton infant. Binomial regression models were used to assess the unadjusted and adjusted prevalence ratios (PRs) and 95% confidence intervals (CI) of the effect of severity of HIV-1 disease, defined by viral load and CD4-positive T-cell counts, on prevalence of LBW and PTD. Results In unadjusted analyses, among those with malaria (n=198), there was no association between severity of HIV-1 infection and LBW, while among women without malaria (n=611), we observed a harmful association between both increasing peripheral viral load and LBW (PR: 1.44 per one-log10 increase, 95% CI: 1.12, 1.86) and placental viral load and LBW (PR: 1.24 per one-log10 increase, 95% CI: 1.00, 1.53). We observed a similar association between increasing placental viral load and PTD (PR: 1.33 per one-log10 increase, 95% CI: 1.04, 1.69). These associations persisted in multivariate models adjusted for residence, maternal education, primigravid status, and maternal anemia. Conclusions In malaria-negative women, maternal HIV-1 disease severity was significantly associated with increased prevalence of LBW and PTD. Such an association was not found in the malaria-infected women.

show abstract

Section: Discussionmentioning

confidence: 99%