HIV-1, HIV-2, human papillomavirus infection and cervical neoplasia in high-risk African women

Langley, Carol; Benga-De, Elisabeth; Critchlow, Cathy W.; Ndoye, Ibra; Mbengue-Ly, Mame Dieumbe; Kuypers, Jane; Woto-Gaye, G.; Mboup, Souleymane; Bergeron, Christine; Holmes, King K.; Kiviat, Nancy B.

doi:10.1097/00002030-199604000-00010

Cited by 77 publications

(49 citation statements)

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“…Prevalence rates of HPV infection ranging from 13 to 40% have been reported from low-risk or general populations of sub-Saharan African countries (Miotti et al, 1996;Temmerman et al, 1999;Castellsague et al, 2001;De Vuyst et al, 2003;Mayaud et al, 2003;Xi et al, 2003;Baay et al, 2004;Thomas et al, 2004;Wall et al, 2005). The 66% prevalence found in the present study, which is still much higher than the 40% prevalence found in similar highrisk populations in Africa (Kreiss et al, 1992;Langley et al, 1996;Piper et al, 1999), might reflect the high sexual exposure of our study population and, as mentioned earlier, may be attributed in part to the exhaustive nature of our HPV detection strategy. Indeed, the use of a primer pair alone to detect HPV by PCR may be responsible for the underestimation of infections with certain HPV types.…”

Section: Discussioncontrasting

confidence: 48%

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

et al. 2006

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Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates belonging to 35 types were identified. Multiple (2 -7 types) HPV infections were observed in 52.9% of HPV-infected women. The most prevalent HPV types were HPV-52 (14.7%), HPV-35 (9.4%), HPV-58 (9.4%), HPV-51 (8.6%), HPV-16 (7.8%), HPV-31 (7.5%), HPV-53 (6.7%), and HPV-18 (6.4%). Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 36.0%. Human papillomavirus prevalence was significantly higher in HIV-1-infected women (87 vs 54%, prevalence ratio ( Cervical cancer is the most frequent cancer of women in developing countries, particularly in sub-Saharan Africa (Parkin et al, 1999), and it is now well established that genital infection with certain types of human papillomavirus (HPV) causes virtually all cases of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) (Walboomers et al, 1999). The HPV types that infect the genital tract have been subdivided into low-risk (LR) types, which are principally found in nonmalignant lesions such as genital warts, and high-risk (HR) types, which are associated with the development of CIN and ICC. Human papillomavirus types 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81, and 89 are classified as LR types, whereas types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82 are classified as HR types. In addition, HPV types 26, 53, and 66 are considered as probably carcinogenic (Muñoz et al, 2003).Human papillomavirus prophylactic vaccines are now being developed and promising results have been obtained with recombinant L1 capsid protein virus-like particles (VLPs). However, the current HPV vaccines target the most prevalent high-risk HPV (HR-HPV) types worldwide, namely HPV-16 and HPV-18 (Koutsky et al, 2002;Ault et al, 2004;Brown et al, 2004;Harper et al, 2004). It has been shown that crossneutralisation induced by L1 VLPs represents less than 1% of the neutralising activity induced by the dominant conformational epitope , indicating that current HPV vaccines would be able to confer only type-specific immunity. Therefore, effectiveness of these vaccines on the prevention of cancer may be lower in populations highly affected by HR-HPV types other than HPV-16 and HPV-18. Thus, it is important to document the distribution of HPV genotypes in HPV-infected women and in women with cervical neoplasia in African countries in order to assess the potential effectiveness of a bivalent HPV-16/18 vaccine.There have been few detailed studies of HPV genotypes and their association with intraepithelial lesions or ICC in sub-Saharan Africa. Available data suggest, however, a higher prevalence and wider spectrum of oncogenic HPV types compared to studies conducted elsewhere (Castellsague et al, 2001;De Vuyst et al, 2003;Mayaud et al, 2003;Clifford et al, 2005;Wall et al, 2005). Furthermore, the high backgr...

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Section: Discussioncontrasting

confidence: 48%

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

et al. 2006

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“…Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) women by one or more high-risk viruses, and 64 (24%) women harbored at least one HPV type from each risk group. Ten cytological smears were not analyzed due to the absence of cervical cells (2), hemorrhage (2), broken slide (2) and lost slide (4). Of the remaining 255, 48 presented alterations compatible with CIN (19%).…”

Section: Resultsmentioning

confidence: 99%

“…In fact, the observed prevalence of 66% is comparable to the 63.2% found by Massad and cols. [3] who made a PCR analysis of cervicovaginal washes from 1,517 HIV-infected North-American women and to the 56% found in HIV-infected Senegalese commercial sex workers [4]. In another study done on 141 HIVinfected women from Santos -Brazil, HPV DNA was detected by PCR in 80.8% of the patients [5].…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

Levi¹,

Mc²,

Cl³

et al. 2002

Braz J Infect Dis

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HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD 4 + cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD 4 /µL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.

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“…The rate of genital HPVs in the United States, as detected by PCR of the L1 region, is ~39.2% (Peyton et al, 2001). Estimates of the rates of HPV in Africa vary from 14% to 60% depending on the country, the coincident STDs, and the methods of detection (Czegledy et al, 1992;Gravitt et al, 2002;Hassen et al, 2003;Langley et al, 1996;Mayaud et al, 2001;Motti et al, 1996;Nzila et al, 1991;O'Farrell et al, 1989;Ong et al, 1993;Serwadda et al, 1999;St. Louis et al, 1993;Thomas et al, 2004;Waddell et al, 1996;Williamson et al, 2002).…”

Section: Epidemiology Of Hpv and Hiv/aidsmentioning

confidence: 99%

“…The rate of HPV infections in HIV-positive patients in Zambia are very high, though rather little data is available (Mosunjac et al, 2003;Patil et al, 1995). As a whole, sub-Saharan Africa has the among the highest rates of cervical cancer in the world (Bailie et al, 1996;Clarke and Chetty, 2002;Langley et al, 1996;ter Meulen et al, 1992;Williamson et al, 2002). The distribution of oncogenic HPVs in Africa differs from the United States and Europe.…”

Section: Epidemiology Of Hpv and Hiv/aidsmentioning

confidence: 99%

The Viral Etiology of AIDS‐Associated Malignancies

Angeletti

Zhang

Wood

2008

Advances in Pharmacology

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HIV-1, HIV-2, human papillomavirus infection and cervical neoplasia in high-risk African women

Cited by 77 publications

References 0 publications

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

The Viral Etiology of AIDS‐Associated Malignancies

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