HIV-1 exposure promotes PKG1-mediated phosphorylation and degradation of stathmin to increase epithelial barrier permeability

Xie, Wei; Chen, Mingzhen; Zhai, Zhaodong; Li, Hongjie; Song, Tieying; Zhu, Yigao; Dong, Dan; Zhou, Peng; Duan, Liangwei; Zhang, You; Li, Dengwen; Liu, Xinqi; Zhou, Jun; Liu, Min

doi:10.1016/j.jbc.2021.100644

Cited by 9 publications

(11 citation statements)

References 52 publications

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“…SGK1 kinase activity is important in Notch1 and p53 proteasomal degradation ( 53 , 54 ). Other cellular proteins are phosphorylated and degraded, such as PKG1-mediated phosphorylation of Stathmin, which promotes its autophagic degradation ( 64 ). Herein, we showed that SGK1’s kinase activity mediated PFV Gag Ser271 and Ser515 phosphorylation, resulting in increased Gag degradation via the lysosomal pathway rather than proteasomal pathways.…”

Section: Discussionmentioning

confidence: 99%

SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication

et al. 2022

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Section: Discussionmentioning

confidence: 99%

SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication

et al. 2022

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“…At the same time, BAT can also increase insulin sensitivity and improve insulin resistance, which plays an important role in regulating the balance of energy metabolism. 23 , 24 , 25 It has been reported that BAT activity is inversely related to body fatness. Because of its potential role in stimulating energy expenditure, BAT is protective against body fat accumulation.…”

Section: Classification and Function Of Adipocytesmentioning

confidence: 99%

“…This process is mediated by close coordination of uncoupling protein‐1 (UCP1) and mitochondrial oxidative machinery. At the same time, BAT can also increase insulin sensitivity and improve insulin resistance, which plays an important role in regulating the balance of energy metabolism 23–25 . It has been reported that BAT activity is inversely related to body fatness.…”

Section: Classification and Function Of Adipocytesmentioning

confidence: 99%

Adipose tissue and hematopoiesis: Friend or foe?

Liu

2023

Clinical Laboratory Analysis

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Aim Hematopoietic stem cells are the origin of all hematopoietic cells. They have the self‐renewal ability and can differentiate into various blood cells. In physiological state, most of the hematopoietic stem cells are dormant, and only a few cells proliferate to maintain hematopoietic homeostasis. Methods This precise steady‐state maintenance is regulated by complex mechanisms. Bone marrow adipocytes make up half of all cells in the bone marrow cavity, a feature that has attracted the attention of researchers from multiple fields. The adipocyte density within marrow increases during aging and obesity. Results Recent studies have shown that bone marrow adipocytes play important roles in regulating hematopoiesis, but the effects of bone marrow adipocytes on hematopoiesis are often conflicting. Bone marrow adipocytes, participating in the formation of bone marrow hematopoietic microenvironment, influence hematopoiesis positively or negatively. In addition, other adipose tissue, especially white adipose tissue, also regulates hematopoiesis. Conclusion In this review, we describe the role of adipose tissue in hematological malignancies, which may be useful for understanding hematopoiesis and the pathogenesis of related diseases.

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“…Recently, we and others have developed several biosensors for monitoring epithelial cell junction proteins, and demonstrated that the arrangement of non-centrosomal microtubules is important for maintaining mucosal epithelial barrier integrity (Du et al, 2020;W. Xie et al, 2020W. Xie et al, , 2021.…”

Section: Functions Of Cell Junctions In the Formation Of Non-centroso...mentioning

confidence: 99%

“…During dorsal closure in Drosophila , non‐centrosomal microtubule arrangement is important for epithelial cell closure, maintenance of adhesion junction proteins, and embryonic tissue development (Spencer et al, 2017). Recently, we and others have developed several biosensors for monitoring epithelial cell junction proteins, and demonstrated that the arrangement of non‐centrosomal microtubules is important for maintaining mucosal epithelial barrier integrity (Du et al, 2020; W. Xie et al, 2020, 2021). Interestingly, cortical microtubules in cultured cells increase the strength of the epithelial layer by strengthening intercellular adhesion junctions (Sumigray et al, 2012).…”

Section: Functions Of Cell Junctions In the Formation Of Non‐centroso...mentioning

confidence: 99%

Organization of cortical microtubules in differentiated cells

Zhou

Gao

Xie

2023

Journal Cellular Physiology

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The microtubule cytoskeleton plays a critical role in a variety of cellular activities, and its structures and functions have been extensively studied. However, little is known about cell differentiation‐related microtubule remodeling, its regulatory mechanisms, and its physiological functions. Recent studies have shown that microtubule‐binding proteins as well as cell junctions, such as desmosomes and adherens junctions, are involved in the remodeling of microtubules in response to cell differentiation. In addition, the microtubule‐organizing activity and structural integrity of centrosomes undergo dramatic changes during cell differentiation to promote microtubule remodeling. Here we summarize recent advances revealing the dynamic changes in microtubule organization and functions during cell differentiation. We also highlight the molecular mechanisms underlying microtubule modeling in differentiated cells, focusing on the key roles played by microtubule‐binding proteins, cell junctions, and centrosomes.

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HIV-1 exposure promotes PKG1-mediated phosphorylation and degradation of stathmin to increase epithelial barrier permeability

Cited by 9 publications

References 52 publications

SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication

SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication

Adipose tissue and hematopoiesis: Friend or foe?

Organization of cortical microtubules in differentiated cells

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